Syed Farooq Adil
King Saud University
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Publication
Featured researches published by Syed Farooq Adil.
Journal of Materials Chemistry | 2015
Mujeeb Khan; Muhammad Nawaz Tahir; Syed Farooq Adil; Hadayat Ullah Khan; M. Rafiq H. Siddiqui; Abdulrahman Al-Warthan; Wolfgang Tremel
Graphene, an atomically thin two-dimensional carbonaceous material, has attracted tremendous attention in the scientific community, due to its exceptional electronic, electrical, and mechanical properties. Indeed, with the recent explosion of methods for a large-scale synthesis of graphene, the number of publications related to graphene and other graphene based materials has increased exponentially. Particularly the development of easy preparation methods for graphene like materials, such as highly reduced graphene oxide (HRG) via reduction of graphite oxide (GO), offers a wide range of possibilities for the preparation of graphene based inorganic nanocomposites by the incorporation of various functional nanomaterials for a variety of applications. In this review, we discuss the current development of graphene based metal and metal oxide nanocomposites, with a detailed account of their synthesis and properties. Specifically, much attention has been given to their wide range of applications in various fields, including electronics, electrochemical and electrical fields. Overall, by the inclusion of various references, this review covers in detail the aspects of graphene-based inorganic nanocomposites.
International Journal of Nanomedicine | 2013
Mujeeb Khan; Merajuddin Khan; Syed Farooq Adil; Muhammad Nawaz Tahir; Wolfgang Tremel; Hamad Z. Alkhathlan; Abdulrahman Al-Warthan; Mohammed Rafiq H. Siddiqui
The green synthesis of metallic nanoparticles (NPs) has attracted tremendous attention in recent years because these protocols are low cost and more environmentally friendly than standard methods of synthesis. In this article, we report a simple and eco-friendly method for the synthesis of silver NPs using an aqueous solution of Pulicaria glutinosa plant extract as a bioreductant. The as-prepared silver NPs were characterized using ultraviolet–visible spectroscopy, powder X-ray diffraction, transmission electron microscopy, energy-dispersive X-ray spectroscopy, and Fourier-transform infrared spectroscopy. Moreover, the effects of the concentration of the reductant (plant extract) and precursor solution (silver nitrate), the temperature on the morphology, and the kinetics of reaction were investigated. The results indicate that the size of the silver NPs varied as the plant extract concentration increased. The as-synthesized silver NPs were phase pure and well crystalline with a face-centered cubic structure. Further, Fourier-transform infrared spectroscopy analysis confirmed that the plant extract not only acted as a bioreductant but also functionalized the NPs’ surfaces to act as a capping ligand to stabilize them in the solvent. The developed eco-friendly method for the synthesis of NPs could prove a better substitute for the physical and chemical methods currently used to prepare metallic NPs commonly used in cosmetics, foods, and medicines.
Nanoscale Research Letters | 2015
Mujeeb Khan; Abdulhadi H. Al-Marri; Merajuddin Khan; Mohammed Rafi Shaik; Nils Mohri; Syed Farooq Adil; Mufsir Kuniyil; Hamad Z. Alkhathlan; Abdulrahman Al-Warthan; Wolfgang Tremel; Muhammad Nawaz Tahir; Mohammed Rafiq H. Siddiqui
Recently, green reduction of graphene oxide (GRO) using various natural materials, including plant extracts, has drawn significant attention among the scientific community. These methods are sustainable, low cost, and are more environmentally friendly than other standard methods of reduction. Herein, we report a facile and eco-friendly method for the bioreduction of GRO using Salvadora persica L. (S. persica L.) roots (miswak) extract as a bioreductant. The as-prepared highly reduced graphene oxide (SP-HRG) was characterized using powder X-ray diffraction (XRD), ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray photoelectron (XPS) spectroscopy, and transmission electron microscopy (TEM). Various results have confirmed that the biomolecules present in the root extract of miswak not only act as a bioreductant but also functionalize the surface of SP-HRG by acting as a capping ligand to stabilize it in water and other solvents. The dispersion quality of SP-HRG in deionized water was investigated in detail by preparing different samples of SP-HRG with increasing concentration of root extract. Furthermore, the dispersibility of SP-HRG was also compared with chemically reduced graphene oxide (CRG). The developed eco-friendly method for the reduction of GRO could provide a better substitute for a large-scale production of dispersant-free graphene and graphene-based materials for various applications in both technological and biological fields such as electronics, nanomedicine, and bionic materials.
International Journal of Molecular Sciences | 2015
Abdulhadi H. Al-Marri; Mujeeb Khan; Merajuddin Khan; Syed Farooq Adil; Abdulrahman Al-Warthan; Hamad Z. Alkhathlan; Wolfgang Tremel; Joselito P. Labis; Mohammed Rafiq H. Siddiqui; Muhammad Nawaz Tahir
A green, one-step approach for the preparation of graphene/Ag nanocomposites (PE-HRG-Ag) via simultaneous reduction of both graphene oxide (GRO) and silver ions using Pulicaria glutinosa plant extract (PE) as reducing agent is reported. The plant extract functionalizes the surfaces of highly reduced graphene oxide (HRG) which helps in conjugating the Ag NPs to HRG. Increasing amounts of Ag precursor enhanced the density of Ag nanoparticles (NPs) on HRG. The preparation of PE-HRG-Ag nanocomposite is monitored by using ultraviolet–visible (UV-Vis) spectroscopy, powder X-ray diffraction (XRD), and energy dispersive X-ray (EDX). The as-prepared PE-HRG-Ag nanocomposities display excellent surface-enhanced Raman scattering (SERS) activity, and significantly increased the intensities of the Raman signal of graphene.
International Journal of Nanomedicine | 2014
Mujeeb Khan; Shams Tabrez Khan; Merajuddin Khan; Syed Farooq Adil; Javed Musarrat; Abdulaziz A. Al-Khedhairy; Abdulrahman Al-Warthan; Mohammed Rafiq H. Siddiqui; Hamad Z. Alkhathlan
The antibacterial properties of nanoparticles (NPs) can be significantly enhanced by increasing the wettability or solubility of NPs in aqueous medium. In this study, we investigated the effects of the stabilizing agent on the solubility of silver NPs and its subsequent effect on their antimicrobial activities. Silver NPs were prepared using an aqueous solution of Pulicaria glutinosa plant extract as bioreductant. The solution also acts as a capping ligand. During this study, the antimicrobial activities of silver NPs, as well as the plant extract alone, were tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Micrococcus luteus. Silver NPs were prepared with various concentrations of the plant extract to study its effect on antimicrobial activity. Interestingly, various concentrations of P. glutinosa extract did not show any effect on the growth of tested bacteria; however, a significant effect on the antimicrobial property of plant extract capped silver NPs (Ag-NPs-PE) was observed. For instance, the half maximal inhibitory concentration values were found to decrease (from 4% to 21%) with the increasing concentrations of plant extract used for the synthesis of Ag-NPs-PE. These results clearly indicate that the addition of P. glutinosa extracts enhances the solubility of Ag-NPs-PE and, hence, increases their toxicity against the tested microorganisms.
Bioorganic & Medicinal Chemistry Letters | 2013
Ahmed Kamal; Jaki R. Tamboli; M.V.P.S. Vishnuvardhan; Syed Farooq Adil; V. Lakshma Nayak; Sistla Ramakrishna
A series of different heteroaromatic linked 4β-amidopodophyllotoxin conjugates (16a-i, 17a-i and 18a-d) were synthesized and evaluated for anticancer activity against five human cancer cell lines. Among the series, one of the compound 17g showed significant antiproliferative activity in A549 (lung cancer) cell line. Flow cytometric analysis showed that 17g arrested the cell cycle in the G2/M phase leading to caspase-3 dependent apoptotic cell death. Further, Hoechst 33258 staining and DNA fragmentation assay also suggests that 17g induces cell death by apoptosis.
Bioorganic & Medicinal Chemistry | 2014
Ahmed Kamal; Jaki R. Tamboli; V. Lakshma Nayak; Syed Farooq Adil; M.V.P.S. Vishnuvardhan; Sistla Ramakrishna
A series of terphenyl based 4-aza-2,3-didehydropodophyllotoxin conjugates (8a-r) were synthesized by a straightforward one-step multicomponent synthesis that demonstrated anticancer activity against five human cancer cell lines (lung, colon, renal, prostate and cervical). All the tested compounds showed potent anticancer activity with IC50 values ranging from 0.87 to 16.59 μM. Among them compounds 8n and 8p showed significant anticancer activity in lung cancer cells with IC50 values 0.91 and 0.87 μM, respectively. Flow cytometric analysis revealed that these compounds induced cell cycle arrest in G2/M phase in A549 cell line leading to caspase-3 dependent apoptotic cell death. The tubulin polymerization assay and immunofluorescence analysis showed that these compounds effectively inhibit microtubule assembly at both molecular and cellular levels in A549 cells. Further, Hoechst staining, DNA fragmentation analysis also suggested that these compounds induced cell death by apoptosis. Overall, the current study demonstrated that the synthesis of terphenyl based 4-aza-2,3-didehydropodophyllotoxin conjugates as promising anticancer agents with G2/M cell cycle arrest and apoptotic-inducing activities via targeting tubulin.
Biotechnology & Biotechnological Equipment | 2016
Abdallah M. Elgorban; Abd El-Rahim M. A. El-Samawaty; Mohamed A. Yassin; Shaban R. M. Sayed; Syed Farooq Adil; Khaled Mohamed Elhindi; Marwa M. Bakri; Mujeeb Khan
ABSTRACT Silver nanoparticles have a high antimicrobial activity and are broadly utilized for several disinfection purposes including water and materials’ sanitization for medical purposes. There have been comparatively few studies on using silver against plant pathogenic fungi. In this study, silver nanoparticles (Ag NPs) were used at concentrations of 0.0, 0.0002, 0.0005, 0.0007, 0.0009, 0.0014 and 0.0019 mol/L. Six different Rhizoctonia solani anastomosis groups (AGs) infecting cotton plants were treated in vitro with Ag NPs on Czapek Dox agar (CDA) and potato dextrose agar plates. The results showed that various concentrations of Ag NPs have antifungal properties to control R. solani AGs. The obtained results also revealed that strong inhibition of R. solani AGs was noticed on CDA at all concentrations.
Nanoscale Research Letters | 2015
Syed Farooq Adil; Saad Alabbad; Mufsir Kuniyil; Mujeeb Khan; Abdulrahman Al-Warthan; Nils Mohri; Wolfgang Tremel; Muhammad Nawaz Tahir; Mohammed Rafiq H. Siddiqui
Vanadia nanoparticles supported on nickel manganese mixed oxides were synthesized by co-precipitation method. The catalytic properties of these materials were investigated for the oxidation of benzyl alcohol using molecular oxygen as oxidant. It was observed that the calcination temperature and the size of particles play an important role in the catalytic process. The catalyst was evaluated for its oxidation property against aliphatic and aromatic alcohols, which was found to display selectivity towards aromatic alcohols. The samples were characterized by employing scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric analysis, and X-ray photoelectron spectroscopy.
Bioorganic & Medicinal Chemistry | 2013
Ahmed Kamal; Jaki R. Tamboli; M. Janaki Ramaiah; Syed Farooq Adil; S.N.C.V.L. Pushpavalli; Raksha Ganesh; Pranjal Sarma; Utpal Bhadra; Manika Pal-Bhadra
A series of new conjugates of quinazolino linked 4β-amidopodophyllotoxins 10aa-af and 10ba-bf were synthesized and evaluated for their anticancer activity against human pancreatic carcinoma (Panc-1) as well as breast cancer cell lines such as MCF-7 and MDA-MB-231 by employing MTT assay. Among these conjugates, some of them like 10bc, 10bd, 10be and 10bf exhibited high potency of cytotoxicity. Flow cytometric analysis showed that these conjugates arrested the cell cycle in the G2/M phase and caused the increase in expression of p53 and cyclin B1 protein with concomitant decrease in Cdk1 thereby suggesting the inhibitory action of these conjugates on mitosis. Interestingly, we observed a decrease in expression of proteins that control the tumor micro environment such as VEGF-A, STAT-3, ERK1/2, ERK-p, AKT-1 ser 473 phosphorylation in compounds treated breast cancer cells. Further, these effective conjugates have exhibited inhibitory action on integrin (αVβIII). Furthermore, the MCF-7 cells that were arrested and lost the proliferative capacity undergo mitochondrial mediated apoptosis by activation of caspases-9. Thus these conjugates have the potential to control breast cancer cell growth by effecting tumor angiogenesis and invasion.