Takumi Sato

Distribution and forms of fluorine in whole blood of human male

Distribution and absolute concentration of three kinds of fluoride/fluorine, i.e., free ionic, ionizable, and organic fluorine, in human whole blood and serum were determined. The method is based on low temperature oxygen plasma ashing, acid hydrolysis, gas chromatography using chlorotrimethylsilane, and fluoride ion-specific electrode. A large part (40%) of the total F is distributed in clot of the whole blood and 74% of the total F is in the form of organic fluorine.

A family with hereditary ankyloglossia complicated by heterochromia irides and a congenital clasped thumb

We experienced a family with hereditary ankyloglossia complicated by heterochromia irides and a congenital clasped thumb. This is considered to be a rare case because, to our knowledge, there have been no published reports on such cases of hereditary complications to date.

Mechanism of Fluoride Absorption from the Gastrointestinal Tract in Rats

Abstract The mechanism involved in the absorption of fluoride by the gastrointestinal tract has been studied by the gastrointestinal reflux method in situ of rat. Reflux was applied to the stomach, small intestine, rectum, and mouth of each animal. At certain intervals during the reflux, a portion of the reflux solution was taken for determination of fluoride uptake. When the stomach or the small intestine was refluxed for 1 hour, the rate of fluoride absorption was decreased with increase in fluoride concentrations, and in the presence of dinitrophenol or saline. These results indicate that the uptake of fluoride from the gastrointestinal tract of the rat may not be limited to passive transport alone.

Experimental Studies on the Effects of Fluoridation on Rats with Experimentally Induced Glomerulonephritis

Abstract The influence of fluoride ingestion on rats with glomerulonephritis has been investigated. Thirty-day-old Wister rats were given nephrotoxin, and five days later, were provided 10 ppm F (as NaF solution) and maintained for 100 days. During the experimental period, body weight, occurrence of mottled enamel in the incisors, and urine and blood chemistry were studied. At the end of the experimental period, the animals were sacrificed, and studied for the presence of dental caries in molars, and the fluoride contents of incisors, molars, mandibles, tibias, and several soft tissues were determined. Histological examinations were performed on some organs. No significant differences in blood chemistry or in histopathology of soft tissues, except the kidney, were observed between the rats with renal disease and the controls. A decrease in body weight was noted in the early stage of the experiment. Furthermore, nephritic animals given drinking water supplemented with 10 ppm F showed a markedly elevated fluoride level in the hard tissues.