Tania Toledo de Oliveira

Epiclusianone: a New Natural Product Derivative of Bicyclo[3.3.1]nonane-2,4,9-trione

Epiclusianone [3-benzoyl-4-hydroxy-6,6-dimethyl-1,5,7-tris(3-methyl-2-butenyl)bicyclo[3.3.1]non-3-ene-2,9-dione] is a new isomeric form of the C 33 H 42 O 4 compound identified by X-ray diffraction analysis. Structure comparison with the known clusianone evidences a case of epimerism in one of the chiral C atoms. A comparison of the melting point and the optical activity of the two isomers shows them to have different values.

Efeito de diferentes doses de flavonóides em ratos hiperlipidêmicos

The objective of this study was to evaluate the effect of different doses of baicalein, morin, naringenin, naringin, quercetin and rutin on the increase of HDL cholesterol and triglycerols levels in hyperlipidemic rats. These flavonoids were administered in three doses (5, 10, 15 mg/animal) to male rats of the Wistar strain, with 30 days of life, fed non-purified diet of formula Labina®. The hyperlipidemia was induced by the administration of Triton, in the dose of 300 mg/kg of rat body weight. After 24 hours, the flavonoids were administered, each dose applied in groups of 8 animals. After 48 hours of Triton application, the animals were anesthetized and samples of blood were collected, by heart puncture, in order to determine cholesterol, cholesterol-HDL and triacylglycerols in the serum. The best results in the reduction of the cholesterol were obtained with quercetin and rutin, in the dose of 5.mg, and naringenin, in the dose of 10 mg. Baicalein in the doses of 5 and 10 mg, showed the best responses for cholesterol-HDL. For triacylglycerols, baicalein also presented the best effects, independently of the dose applied.