Teresa Botti

Transient-evoked otoacoustic emission generators in a nonlinear cochlea

This study focuses on the theoretical prediction and experimental evaluation of the latency of transient-evoked otoacoustic emissions. Response components with different delay have been identified in several studies. The main generator of the transient response is assumed to be coherent reflection from cochlear roughness near the resonant place. Additional components of different latency can be generated by different mechanisms. Experimental data are re-analyzed in this study to evaluate the dependence of the latency on stimulus level, for each component of the response, showing that previous estimates of the otoacoustic emission latency were affected by systematic errors. The latency of the emission from each generator changes very little with stimulus level, whereas their different growth rate causes sharp changes of the single-valued latency, estimated as the time of the absolute maximum of the bandpass filtered response. Results of passive linear models, in which gain and bandwidth of the cochlear amplifier are strictly related, are incompatible with the observations. Although active linear models including delayed stiffness terms do predict much slower dependence of latency on the stimulus level, a suitable nonlinear model should be designed, capable of decoupling more effectively the dependence on stimulus level of amplitude and phase of the otoacoustic response.

Different models of the active cochlea, and how to implement them in the state-space formalism

The state-space formalism [Elliott S. J., et al. (2007). J. Acoust. Soc. Am. 122, 2759-2771] allows one to discretize cochlear models in a straightforward matrix form and to modify the main physical properties of the cochlear model by changing the position and functional form of a few matrix elements. Feed-forward and feed-backward properties can be obtained by simply introducing off-diagonal terms in the matrixes expressing the coupling between the dynamical variables and the additional active pressure on the basilar membrane. Some theoretical issues related to different cochlear modeling choices, their implementation in a state-space scheme, and their physical consequences on the cochlear phenomenology, as predicted by numerical simulations, are discussed. Different schematizations of the active term describing the behavior of the outer hair cells feedback mechanism, including nonlinear and nonlocal dependences on either pressure or basilar membrane displacement, are also discussed, showing their effect on some measurable cochlear properties.

Distortion product otoacoustic emission generation mechanisms and their dependence on stimulus level and primary frequency ratio

In this study, a systematic analysis of the dependence on stimulus level and primary frequency ratio r of the different components of human distortion product otoacoustic emissions has been performed, to check the validity of theoretical models of their generation, as regards the localization of the sources and the relative weight of distortion and reflection generation mechanisms. 2f1 - f2 and 2f2 - f1 distortion product otoacoustic emissions of 12 normal hearing ears from six human subjects have been measured at four different levels, in the range [35, 65] dB sound pressure level, at eight different ratios, in the range [1.1, 1.45]. Time-frequency filtering was used to separate distortion and reflection components. Numerical simulations have also been performed using an active nonlinear cochlear model. Both in the experiment and in the simulations, the behavior of the 2f1 - f2 distortion and reflection components was in agreement with previous measurements and with the predictions of the two-source model. The 2f2 - f1 response showed a rotating-phase component only, whose behavior was in general agreement with that predicted for a component generated and reflected within a region basal to the characteristic place of frequency 2f2 - f1, although alternative interpretations, which are also discussed, cannot be ruled out.

Otoacoustic Emissions as a Promising Diagnostic Tool for the Early Detection of Mild Hearing Impairment - Technical Advances in Acquisition, Analysis and Modeling

Otoacoustic emissions are a by-product of the active nonlinear amplification mechanism located in the cochlear outer hair cells, which provides high sensitivity and frequency resolution to human hearing. Being intrinsically sensitive to hearing loss at a cochlear level, they represent a promising non-invasive, fast, and objective diagnostic tool. On the other hand, the complexity of their linear and nonlinear generation mechanisms and other confounding physical phenomena (e.g., interference between different otoacoustic components, acoustical resonances in the ear canal, transmission of the middle ear) introduce a large inter-subject variability in their measured levels, which makes it difficult using them as a direct measure of the hearing threshold using commercially available devices. Nonlinear cochlear modeling has been successfully used to understand the complexity of the otoacoustic generation mechanisms, and to design new acquisition and analysis techniques that help disentangling the different components of the otoacoustic response, therefore improving the correlation between measured otoacoustic levels and audiometric thresholds. In particular, nonlinear cochlear modeling was able to effectively describe the complex (amplitude and phase) response of the basilar membrane, and the generation of otoacoustic emissions by two mechanisms, nonlinear distortion and linear reflection by cochlear roughness. Different phase-frequency relations are predicted for the otoacoustic components generated by the two mechanisms, so they can be effectively separated according to their different phase-gradient delay, using an innovative time-frequency domain filtering technique based on the wavelet transform. A brief introduction to these topics and some new theoretical and experimental results are presented and discussed in this study.

DPOAE generation dependence on primary frequencies ratio

Two different mechanisms are responsible for the DPOAE generation. The nonlinear distortion wave-fixed mechanism generates the DPOAE Zero-Latency (ZL) component, as a backward traveling wave from the “overlap” region. Linear reflection of the forward DP wave (IDP) generates the DPOAE Long-Latency (LL) component through a place-fixed mechanism. ZL and LL components add up vectorially to generate the DPOAE recorded in the ear canal. The 2f1 − f2 and 2f2 − f1 DPOAE intensity depends on the stimulus level and on the primary frequency ratio r = f2/f1, where f1 and f2 are the primary stimuli frequencies. Here we study the behavior of the ZL and LL DPOAE components as a function of r by both numerical and laboratory experiments, measuring DPAOEs with an equal primary levels (L1 = L2) paradigm in the range [35, 75] dB SPL, with r ranging in [1.1, 1.45]. Numerical simulations of a nonlocal nonlinear model have been performed without cochlear roughness, to suppress the linear reflection mechanism. In this way the m...

Numerical Simulations of Otoacoustic Emissions from a Non-linear Non-local Cochlear Model

Otoacoustic emissions are numerically simulated from a nonlinear nonlocal cochlear model solved in time domain by means of the space‐state matrix technique. The feedback mechanism localized in the outer hair cells system is modeled as a nonlinear active force proportional to the total pressure acting on the basilar membrane or as an anti‐damping nonlinear term proportional to the velocity of the membrane itself. The model seems to be a very good tool for simulating cochlear dynamics in different regimes of the cochlear parameters and in particular when strong nonlinearities are put into the model.