Tess Harris

Has loneliness amongst older people increased? An investigation into variations between cohorts.

Loneliness has been consistently identified as one of the specific ‘social problems’ which accompanies old age and growing older: 90 per cent of the general population of Britain feel that loneliness is a problem associated with old age. There is a widespread presumption that loneliness and isolation have become more prevalent in Britain in the period since the Second World War as a result of the decline in multi-generation households and changes in family structure. This paper examines the accuracy of this stereotype and considers if current cohorts of older people are more likely to report experiencing loneliness than previous generations of elders, through a comparative analysis of historical and contemporary data. Historical data are provided by three ‘classic’ social surveys undertaken in England between 1945 and 1960. Contemporary data are from a postal survey of 245 people aged 65–74 living in South London in 1999. The questions used in all four surveys were comparable, in that respondents self-rated their degree of loneliness on scales ranging from never to always. The overall prevalence of reports of loneliness ranged from five to nine per cent and showed no increase. Loneliness rates for specific age or gender sub-groups were also stable. Reported loneliness amongst those living alone decreased from 32 per cent in 1945 to 14 per cent in 1999, while the percentages decreased for both those reporting that they were never lonely and that they were ‘sometimes’ lonely.

Randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of selective serotonin reuptake inhibitors plus supportive care, versus supportive care alone, for mild to moderate depression with somatic symptoms in primary care: the THREAD (THREshold for AntiDepressant response) study

OBJECTIVES To determine (1) the effectiveness and cost-effectiveness of selective serotonin reuptake inhibitor (SSRI) treatment plus supportive care, versus supportive care alone, for mild to moderate depression in patients with somatic symptoms in primary care; and (2) the impact of the initial severity of depression on effectiveness and relative costs. To investigate the impact of demographic and social variables. DESIGN The study was a parallel group, open-label, pragmatic randomised controlled trial. SETTING The study took place in a UK primary care setting. Patients were referred by 177 GPs from 115 practices around three academic centres. PARTICIPANTS Patients diagnosed with new episodes of depression and potentially in need of treatment. In total, 602 patients were referred to the study team, of whom 220 were randomised. INTERVENTIONS GPs were asked to provide supportive care to all participants in follow-up consultations 2, 4, 8 and 12 weeks after the baseline assessment, to prescribe an SSRI of their choice to patients in the SSRI plus supportive care arm and to continue treatment for at least 4 months after recovery. They could switch antidepressants during treatment if necessary. They were asked to refrain from prescribing an antidepressant to those in the supportive care alone arm during the first 12 weeks but could prescribe to these patients if treatment became necessary. MAIN OUTCOME MEASURES The primary outcome measure was Hamilton Depression Rating Scale (HDRS) score at 12-week follow-up. Secondary outcome measures were scores on HDRS at 26-week follow-up, Beck Depression Inventory, Medical Outcomes Study Short Form-36 (SF-36), Medical Interview Satisfaction Scale (MISS), modified Client Service Receipt Inventory and medical record data. RESULTS SSRIs were received by 87% of patients in the SSRI plus supportive care arm and 20% in the supportive care alone arm. Longitudinal analyses demonstrated statistically significant differences in favour of the SSRI plus supportive care arm in terms of lower HDRS scores and higher scores on the SF-36 and MISS. Significant mean differences in HDRS score adjusted for baseline were found at both follow-up points when analysed separately but were relatively small. The numbers needed to treat for remission (to HDRS > 8) were 6 [95% confidence interval (CI) 4 to 26)] at 12 weeks and 6 (95% CI 3 to 31) at 26 weeks, and for significant improvement (HDRS reduction > or = 50%) were 7 (95% CI 4 to 83) and 5 (95% CI 3 to 13) respectively. Incremental cost-effectiveness ratios and cost-effectiveness planes suggested that adding an SSRI to supportive care was probably cost-effective. The cost-effectiveness acceptability curve for utility suggested that adding an SSRI to supportive care was cost-effective at the values of 20,000 pounds-30,000 pounds per quality-adjusted life-year. A poorer outcome on the HDRS was significantly related to greater severity at baseline, a higher physical symptom score and being unemployed. CONCLUSIONS Treatment with an SSRI plus supportive care is more effective than supportive care alone for patients with mild to moderate depression, at least for those with symptoms persisting for 8 weeks and an HRDS score of > or = 12. The additional benefit is relatively small, and may be at least in part a placebo effect, but is probably cost-effective at the level used by the National Institute for Health and Clinical Excellence to make judgements about recommending treatments within the National Health Service. However, further research is required.

An evaluation of the Team Objective Structured Clinical Examination (TOSCE).

To evaluate the validity, reliability and feasibility of the TOSCE, a new means of formative assessment for medical students, from the perspectives of examiners, simulated patients and students.

Ethnic differences in use of hormone replacement therapy: community based survey.

Hormone replacement therapy is widely promoted to prevent cardiovascular disease and osteoporosis and relieve menopausal symptoms, although concern exists that much of the cardiovascular effect may be due to its selection by healthy women.1 Little is known about its use by women from different ethnic groups in the United Kingdom, particularly women of south Asian origin, who are at increased risk of coronary heart disease,2 osteoporosis,3 and diabetes4 compared with white women. A population based survey was carried out in Wandsworth, south London, where roughly 12% of residents are from the Caribbean or west Africa (that is, of African descent) and 6% are of Indian, Pakistani, or Bangladeshi origin (that is, south Asian). Women aged 40-59 were invited from nine general practices as part of a cardiovascular screening study.4 The response rate was 66% (941/1429). Of the 941 women screened, 882 were from one of the ethnic groups being studied. Ethnic group was recorded at interview on the basis of answers to several questions, including questions on country of …

Differences in hormone replacement therapy use by social class, region and psychological symptoms

Objective To describe the relationship between socio‐demographic factors, heart disease risk factors, psychological symptoms and the use of hormone replacement therapy by English women.

Vocational training for general practice in inner London. Is there a dearth? And if so what's to be done?

Abstract Objective: To identify the nature and extent of any vocational training deficit within the London initiative zone and investigate the reasons. Design: Collation of statistics and postal questionnaire surveys. Setting: Thames regions inside and outside the London initiative zone. Subjects: General practice registrars, trainers, principals from non-training practices, and vocational training course organisers. Main outcome measures: Trends in numbers of general practice registrars, proportions of trainers, views on current vocational training in inner London. Results: Numbers of general practice registrars fell significantly between 1988 and 1993 within the London initiative zone and in England overall. The number of registrars within the zone fell by more than in the rest of the Thames regions, where the decline was not statistically significant. A lower proportion of principals were approved as trainers within the zone than in the rest of the Thames regions and England overall. In their responses to the survey (88% of inner London registrars responded and 81% of outer Thames registrars) registrars suggested that improving remuneration and personal safety would make training in London more attractive. Trainers and non-trainers (response rates 89% and 66% respectively) also suggested increasing remuneration for trainers together with more protected time for training. Conclusions: Less vocational training takes place within the London initiative zone than in the rest of the Thames regions and England overall, although there are discrepancies in official statistics. As well as specific recommendations for improving recruitment to vocational training in inner London, measures to tackle inner city deprivation should also remain high on the political agenda. Key messages Key messages The proportion of general practice principals who are approved trainers is lower in inner London than in the rest of the Thames regions or England Increased remuneration and improvements to personal safety are required to attract registrars to inner London Only 28% of inner London general practice registrars intend to become principals immediately on completion of their training Increased remuneration and protected time for training are required to encourage more principals to become trainers

Primary care pedometer-based walking intervention: mixed-methods results from 3 year follow-up of PACE-UP cluster-randomised controlled trial

Abstract Background Maintenance of physical activity is important for health, but few trials provide long-term objective data or qualitative evaluation of factors affecting this maintenance. The PACE-UP three-arm (postal, nurse-support, control) primary care cluster-randomised controlled trial recruited 1023 adults aged 45–75 years into a 12 week pedometer-based intervention including a physical activity diary and handbook incorporating behaviour change techniques; controls received usual care. Recruitment was from Sept 1, 2012, to Oct 31, 2013. At 12 months, step-counts increased by around a tenth, and time in moderate-to-vigorous physical activity (MVPA) in bouts by around a third in postal and nurse-supported arms compared with control. Using a mixed-methods approach at 3 year follow-up of the PACE-UP cohort, we aimed to assess whether the intervention effects persisted. Methods Assessments were done between Oct 1, 2015, and Nov 30, 2016. Mean daily step-counts and total weekly minutes of MVPA in bouts of 10 min or more at 3 years were collected with 7 day GT3X+ accelerometry (Actigraph, Pensacola, FL, USA) for all trial arms. Outcomes were regressed on baseline values to estimate change in treatment groups compared with control. Sensitivity analysis assessed missing data effects. Semi-structured telephone interviews were conducted with 60 participants. Interviews were audio recorded, transcribed, and coded, and thematic analysis was performed. Ethics approval was given by the National Research Ethics Service Committee London (Hampstead). Findings 3 year follow-up with accelerometry was 67% (681/1023). Compared with controls, intervention groups maintained higher steps per day (postal 627 additional steps[95% CI 198–1056], p=0·004; nurse 670 [237–1102], p=0·002), and more total weekly minutes of MVPA in bouts (postal 28 [7–49], p=0·009; nurse 24 [3–45], p=0·03). Results were robust to sensitivity analyses. Most interviewees felt that PACE-UP had increased their awareness of their physical activity. Facilitators to physical activity maintenance included self-motivation, social-support, and maintaining good health, with poor health and lack of time as barriers. Interpretation At 3 year follow-up of PACE-UP, step-counts and bouts of MVPA persisted, with no difference between intervention groups, suggesting that a primary care pedometer intervention, delivered by post or with nurse support, could help address the public health physical inactivity challenge. Major future challenges are how to apply this kind of effective intervention widely in the population and how to transform perceived barriers into facilitators (eg, poor physical health). Funding National Institute for Health Research Health Technology Assessment Programme (project number HTA 10/32/02).