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Featured researches published by Tetsuhiro Mikami.


Bioorganic & Medicinal Chemistry | 1998

Syntheses and preventive effects of analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) on bone mineral loss in ovariectomized rats

Yoshiyuki Ono; Akira Kawase; Hiroyoshi Watanabe; Ayako Shiraishi; Satoshi Takeda; Yoshinobu Higuchi; Katsuhiko Sato; Tsuyoshi Yamauchi; Tetsuhiro Mikami; Masahiro Kato; Naoko Tsugawa; Toshio Okano; Noboru Kubodera

Analogues related to 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity.


Synthetic Communications | 1997

Practical Formation of γ-Keto or γ-Hydroxy Ether Linkage from Alcohol1

Tetsuhiro Mikami; Tomoyasu Iwaoka; Masahiro Kato; Hiroyoshi Watanabe; Noboru Kubodera

Abstract A practically useful formation of γ-keto or γ-hydroxy ether linkage from alcohol, for the construction of the side chain of 1α, 25-dihydroxy-22-oxavitamin D3 (OCT), is described.


Organic Process Research & Development | 2005

Industrial Synthesis of Maxacalcitol, the Antihyperparathyroidism and Antipsoriatic Vitamin D3 Analogue Exhibiting Low Calcemic Activity

Hitoshi Shimizu; Kazuki Shimizu; Noboru Kubodera; Tetsuhiro Mikami; Kaname Tsuzaki; Hiroyuki Suwa; Koji Harada; Akira Hiraide; Motoki Shimizu; Kaichiro Koyama; Yoshihide Ichikawa; Daisuke Hirasawa; Yasushi Kito; Mio Kobayashi; Masaharu Kigawa; Masahiro Kato; Toshiro Kozono; Hideki Tanaka; Makoto Tanabe; Masanori Iguchi; Mitsutaka Yoshida


Archive | 1999

ULTRAVIOLET IRRADIATION APPARATUS FOR PHOTOCHEMICAL REACTION AND METHOD FOR PREPARING VITAMIN D DERIVATIVE USING THE SAME

Tadao Michishita; Satoshi Watanabe; Masahiro Katoh; Tetsuhiro Mikami; Kaname Tsuzaki; Koji U. Denki K. K. Sumit. F. Shiba bld Oikawa; Makoto Uehara


Archive | 1992

22-oxacholecalciferol derivative and production thereof.

Masahiro Kato; Tetsuhiro Mikami; Kiyoshige Ochi; Hiroyoshi Watanabe; Noboru Chugai Seiyaku Kubodera


Archive | 1992

22-oxacholecalciferol derivative and process for preparing the same

Masahiro Kato; Tetsuhiro Mikami; Kiyoshige Ochi; Hiroyoshi Watanabe; Noboru Kubodera


Archive | 1992

22-oxacholecalciferol derivative and its production

Masahiro Kato; Noboru Kubodera; Tetsuhiro Mikami; Kiyoshige Ochi; Hiroyoshi Watanabe; 哲弘 三上; 登 久保寺; 昌宏 加藤; 博義 渡邉; 清成 越智


Archive | 2003

Ultraviolet irradiation apparatus for photochemical reaction and preparation process of vitamin D derivative making use of the same

Tadao Michishita; Satoshi Watanabe; Masahiro Katoh; Tetsuhiro Mikami; Kaname Tsuzaki; Koji U. Denki K. K. Sumit. F. Shiba bld Oikawa; Makoto Uehara


Journal of Synthetic Organic Chemistry Japan | 2009

Practical Synthesis of Maxacalcitol Based on Usefully Classical Reactions and Photolysis

Hitoshi Shimizu; Tetsuhiro Mikami; Masahiro Kato


Tetrahedron Letters | 2004

Synthesis of 21-nor-22-oxa-1α,25-dihydroxyvitamin D3 derivatives in quest of a drug with low calcemic activity

Hitoshi Shimizu; Kazuki Shimizu; Yasushi Uchiyama; Atsuko Sugita; Tetsuhiro Mikami; Tsuyoshi Yamauchi; Masahiro Kato; Kazumi Morikawa

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Masahiro Kato

Chugai Pharmaceutical Co.

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Noboru Kubodera

Chugai Pharmaceutical Co.

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Kiyoshige Ochi

Chugai Pharmaceutical Co.

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Hitoshi Shimizu

Chugai Pharmaceutical Co.

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Kazuki Shimizu

Chugai Pharmaceutical Co.

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Tomoyasu Iwaoka

Chugai Pharmaceutical Co.

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Akira Kawase

Chugai Pharmaceutical Co.

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Atsuko Sugita

Chugai Pharmaceutical Co.

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