Thilo Michel

Grating-based x-ray phase-contrast imaging with a multi energy-channel photon-counting pixel detector.

We have carried out grating-based x-ray differential phase-contrast measurements with a hybrid pixel detector in 16 energy channels simultaneously. A method for combining the energy resolved phase-contrast images based on energy weighting is presented. An improvement in contrast-to-noise ratio by 58.2% with respect to an emulated integrating detector could be observed in the final image. The same image quality could thus be achieved with this detector and with energy weighting at 60.0% reduced dose compared to an integrating detector. The benefit of the method depends on the object, spectrum, interferometer design and the detector efficiency.

Reconstruction method for grating-based x-ray phase-contrast images without knowledge of the grating positions

To retrieve the phase information of x-rays using a Talbot-Lau interferometer, the knowledge of the grating positions is mandatory. Transferring the interferometer technique from the laboratory to a conventional x-ray imaging system, this requirement is no longer guaranteed. This is due to distortions and vibrations which are coupled into the interferometer. Therefore, we applied a principal-component analysis to Talbot-Lau x-ray phase-contrast data. In experiments we compared this alternative approach for image reconstruction to the conventional procedure. As a result, a superior robustness of the principal-component analysis against imperfect phase-stepping data was found. Furthermore, using the proposed method, the reconstruction of x-ray phase-contrast images from randomly distributed phase-step positions is possible.

Energy weighted x-ray dark-field imaging

The dark-field image obtained in grating-based x-ray phase-contrast imaging can provide information about the objects microstructures on a scale smaller than the pixel size even with low geometric magnification. In this publication we demonstrate that the dark-field image quality can be enhanced with an energy-resolving pixel detector. Energy-resolved x-ray dark-field images were acquired with a 16-energy-channel photon-counting pixel detector with a 1 mm thick CdTe sensor in a Talbot-Lau x-ray interferometer. A method for contrast-noise-ratio (CNR) enhancement is proposed and validated experimentally. In measurements, a CNR improvement by a factor of 1.14 was obtained. This is equivalent to a possible radiation dose reduction of 23%.

Optimization procedure for a Talbot-Lau x-ray phase-contrast imaging system

In Talbot-Lau x-ray imaging, the fringe visibility provided by the interferometer is a crucial quality parameter to preserve high quality images at an acceptable dose level. The noise of the obtained differential phase signal and the dark-field image is directly influenced by the visibility. To optimize the performance of such an interferometer, we use wave-field simulations to investigate the effect of the phase grating G1. Therefore, we varied the grating parameters duty cycle and grating bar height. Each set of these parameters were evaluated for different propagation distances and for multiple x-ray spectra. In this multidimensional space the interferometer configuration with the highest visibility over a wide range of energies was selected to cover a multiple possible x-ray applications. We manufactured the optimized phase grating G1, the corresponding source grating G0 and analyzer grating G2 and compare the experimental results with the expected results obtained from simulations. The presented measurements show outstanding visibilities up to 50% using a broad x-ray spectrum. These measurements are in very good agreement to the simulation results. The achieved visibility is up to two times higher than for a standard-type setup. This enhancement results in high quality images at a reasonable dose level which we exemplarily demonstrate by imaging a foreign object in a pork trotter.

Increasing the darkfield contrast-to-noise ratio using a deconvolution-based information retrieval algorithm in X-ray grating-based phase-contrast imaging

A novel information retrieval algorithm for X-ray grating-based phase-contrast imaging based on the deconvolution of the object and the reference phase stepping curve (PSC) as proposed by Modregger et al. was investigated in this paper. We applied the method for the first time on data obtained with a polychromatic spectrum and compared the results to those, received by applying the commonly used method, based on a Fourier analysis. We confirmed the expectation, that both methods deliver the same results for the absorption and the differential phase image. For the darkfield image, a mean contrast-to-noise ratio (CNR) increase by a factor of 1.17 using the new method was found. Furthermore, the dose saving potential was estimated for the deconvolution method experimentally. It is found, that for the conventional method a dose which is higher by a factor of 1.66 is needed to obtain a similar CNR value compared to the novel method. A further analysis of the data revealed, that the improvement in CNR and dose efficiency is due to the superior background noise properties of the deconvolution method, but at the cost of comparability between measurements at different applied dose values, as the mean value becomes dependent on the photon statistics used.

A beam hardening and dispersion correction for x-ray dark-field radiography.

PURPOSEnX-ray dark-field imaging promises information on the small angle scattering properties even of large samples. However, the dark-field image is correlated with the objects attenuation and phase-shift if a polychromatic x-ray spectrum is used. A method to remove part of these correlations is proposed.nnnMETHODSnThe experimental setup for image acquisition was modeled in a wave-field simulation to quantify the dark-field signals originating solely from a materials attenuation and phase-shift. A calibration matrix was simulated for ICRU46 breast tissue. Using the simulated data, a dark-field image of a human mastectomy sample was corrected for the finger print of attenuation- and phase-image.nnnRESULTSnComparing the simulated, attenuation-based dark-field values to a phantom measurement, a good agreement was found. Applying the proposed method to mammographic dark-field data, a reduction of the dark-field background and anatomical noise was achieved. The contrast between microcalcifications and their surrounding background was increased.nnnCONCLUSIONSnThe authors show that the influence of and dispersion can be quantified by simulation and, thus, measured image data can be corrected. The simulation allows to determine the corresponding dark-field artifacts for a wide range of setup parameters, like tube-voltage and filtration. The application of the proposed method to mammographic dark-field data shows an increase in contrast compared to the original image, which might simplify a further image-based diagnosis.

Energy-resolved interferometric x-ray imaging

Interferometric X-ray imaging becomes more and more attractive for applications such as medical imaging or non-destructive testing, where a compact setup is needed. Therefore a so-called Talbot-Lau interferometer in combination with a conventional X-ray tube is used. Thereby, three different kinds of images can be obtained. An attenuation image like in conventional X-ray imaging, an image of the differential phase-shifts caused by the object and the so-called dark-field image. The dark-field image shows information about the objects granularity even in sub-pixel dimensions what especially seems very promising for applications like mammography. With respect to optimizing the output of interferometric X-ray imaging in any application, it is inevitable to know the energy response of the interferometer as well as the energy dependence of the interactions of X- rays with matter. In this contribution, simulations and measurements using a Medipix 2 and a Timepix detector are presented.

Implementation of a Talbot-Lau interferometer in a clinical-like c-arm setup: A feasibility study

X-ray grating-based phase-contrast imaging has raised interest regarding a variety of potential clinical applications, whereas the method is feasible using a medical x-ray tube. Yet, the transition towards a clinical setup remains challenging due to the requirement of mechanical robustness of the interferometer and high demands applying to medical equipment in clinical use. We demonstrate the successful implementation of a Talbot-Lau interferometer in an interventional c-arm setup. The consequence of vibrations induced by the rotating anode of the tube is discussed and the prototype is shown to provide a visibility of 21.4% at a tube voltage of 60u2009kV despite the vibrations. Regarding clinical application, the prototype is mainly set back due to the limited size of the field of view covering an area of 17u2009mmu2009×u200946u2009mm. A c-arm offers the possibility to change the optical axis according to the requirements of the medical examination. We provide a method to correct for artifacts that result from the angulation of the c-arm. Finally, the images of a series of measurements with the c-arm in different angulated positions are shown. Thereby, it is sufficient to perform a single reference measurement in parking position that is valid for the complete series despite angulation.

Talbot‐Lau X‐ray phase contrast for tiling‐based acquisitions without reference scanning

Purpose Grating‐based Talbot‐Lau interferometers are a popular choice for phase‐contrast X‐ray acquisitions. Here, an air reference scan has to be acquired prior to an object scan. This particularly complicates acquisition of large objects: large objects are tiled into multiple scans due to the small field of view of current gratings. However, phase reference drifts occurring between these scans may require to repeatedly move the object in and out of the X‐ray beam to update the reference information. Methods We developed an image processing technique that completely removes the need for phase reference scans in tiled acquisitions. We estimate the reference from object scans using a tailored iterated robust regression, using a novel efficient optimizer. Results Our evaluation indicates that the estimated reference is not only close to the acquired reference but also improves the final image quality. We hypothesize that this is because we mitigate errors that are introduced when actually acquiring the reference phase. Conclusion Phase‐contrast imaging of larger objects may benefit from computational estimation of phase reference data due to reduced scanning complexity and improved image quality.

Grating-based dark-field breast imaging

Grating-based X-ray phase-contrast imaging (XPCI) is a promising modality to increase soft-tissue contrast in medical imaging and especially in the case of mammography. Several groups worldwide have performed investigations on grating-based Talbot-Lau X-ray imaging of breast tissue, but in most cases focussed on the soft tissue contrast enhancement of the differential phase image. In this contribution, we present promising measurements with a Talbot-Lau interferometer of several mastectomy breast tissue samples especially focussed on the sensitivity of the dark-field signal of microcalcifications and with a comparable dose value to conventional mammography. We can present a contrast improvement for calcifications in surrounding breast tissue for the dark-field image by a factor of 10 related to the attenuation image.