Thomas J. Lehmann | Researchain

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Featured researches published by Thomas J. Lehmann.

Nucleosides, Nucleotides & Nucleic Acids | 2001

DESIGN AND PROPERTIES OF HEPATITIS C VIRUS ANTISENSE OLIGONUCLEOTIDES FOR LIVER SPECIFIC DRUG TARGETING

Thomas J. Lehmann; Matthias Serwe; Wolfgang H. Caselmann; Joachim W. Engels

Different backbone modified antisense oligonucleotides (AS-ODNs) directed against the hepatitis C virus genome were 5′-conjugated to cholesterol, cholic acid or taurocholic acid to enhance liver specific drug targeting and hepatocellular uptake. The lipophilic character of modified AS-ODNs was determined from RP-HPLC retentiontimes and duplex stability was correlated with Tm-values from UV melting curves.

Nucleosides, Nucleotides & Nucleic Acids | 1999

Thermodynamic Studies on Hairpin Forming Antisense-Oligodeoxynucleotides Directed Against Hepatitis C Virus RNA

Thomas J. Lehmann; Stefan Eisenhardt; Joachim W. Engels

Phosphorothioate and benzyl-modified antisense-oligodeoxynucleotides directed against nucleotides 334-350 of the Hepatitis C Virus RNA form surprisingly stable hairpins. These data contribute to solve a structural detail information in search for a global secondary structure model of the Non Coding Region (NCR) of HCV.

Nucleosides, Nucleotides & Nucleic Acids | 1997

Synthesis and Characterization of Phosphate-modified DNA-Dimers with Fluorine as an uncharged Ligand

Thomas J. Lehmann; Stefan Eisenhardt; Joachim W. Engels

Abstract The potential of the dinucleosidylphosphorofluoridates dCpFdG and dApFdT is described. Side products of the phosphoramidite coupling reaction are synthesized and characterized by 31P-NMR-spectroscopy.

Bioorganic & Medicinal Chemistry | 2001

Synthesis and properties of bile acid phosphoramidites 5'-tethered to antisense oligodeoxynucleotides against HCV.

Thomas J. Lehmann; Joachim W. Engels

World Journal of Gastroenterology | 2014

Parameters of a severe disease course in ulcerative colitis

Andreas Stallmach; Luisa Nickel; Thomas J. Lehmann; Bernd Bokemeyer; Martin Bürger; D Hüppe; Wolfgang Kruis; Susanna Nikolaus; Jan C. Preiss; Andreas Sturm; Niels Teich; Carsten Schmidt

Antiviral Research | 2013

Inhibition of hepatitis C virus RNA translation by antisense bile acid conjugated phosphorothioate modified oligodeoxynucleotides (ODN)

Maria A. Gonzalez-Carmona; Maria Quasdorff; A. Vogt; Anja Tamke; Yildiz Yildiz; Per Hoffmann; Thomas J. Lehmann; Ralf Bartenschlager; Joachim W. Engels; Gerd A. Kullak-Ublick; Tilman Sauerbruch; Wolfgang H. Caselmann

World Journal of Gastroenterology | 2000

Design, delivery and efficacy testing of therapeutic nucleic acids used to inhibit hepatitis C virus gene expression in vitro and in vivo

Wolfgang H. Caselmann; Matthias Serwe; Thomas J. Lehmann; Janos Ludwig; Brian S. Sproat; Joachim W. Engels

Gastroenterology | 2017

The Influence of Meteorological Factors on the Incidence of Acute Upper Gastrointestinal Hemorrhage

Florian Prechter; Martin Bürger; Thomas J. Lehmann; Carsten Schmidt; Andreas Stallmach

Hepatology | 2003

980 Inhibition of hepatitis C virus RNA translation with antisense taurocholate conjugated phosphorothioate modified oligodeoxynucleotides (ODN) in cell culture

Maria Quasdorff; Maria A. Gonzalez-Carmona; Anja Tamke; Per Hoffmann; Thomas J. Lehmann; Joachim W. Engels; Gerd A. Kullak-Ublick; Tilman Sauerbruch; Wolfgang H. Caselmann

Collection of Czechoslovak Chemical Communications | 2002