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Tomoyuki Hasegawa

Nagoya University

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Publication

Featured researches published by Tomoyuki Hasegawa.

Bioorganic & Medicinal Chemistry | 2002

A practical synthesis and biological evaluation of 9-halogenated PGF analogues.

Kousuke Tani; Atsushi Naganawa; Akiharu Ishida; Hiromu Egashira; Yoshihiko Odagaki; Toru Miyazaki; Tomoyuki Hasegawa; Yasufumi Kawanaka; Kenji Sagawa; Hiroyuki Harada; Mikio Ogawa; Takayuki Maruyama; Hisao Nakai; Shuichi Ohuchida; Kigen Kondo; Masaaki Toda

A series of 9-halo PGF analogues 1-2 and 5-13 were synthesized and biologically evaluated. Among the compounds, 2 was the best EP2-receptor agonist. A practical method of synthesizing 2 via the Julia olefination of an aldehyde 3 with an optically active sulfone 4, which was prepared by Sharpless asymmetric epoxidation of 15, was developed. Other 9-halogenated PGF analogues were synthesized essentially by the same procedure and evaluated. The absolute configuration of 16-OH of 2 was determined as S by the X-ray analysis of a salt consisting of a 1/1 molar ratio of 2 and L-lysine.

Bulletin of the Chemical Society of Japan | 2000

A Practical Synthesis of Optically Active (R)-2-Propyloctanoic Acid: Therapeutic Agent for Alzheimer's Disease

Tomoyuki Hasegawa; Hisashi Yamamoto

Archive | 2002

Indole derivatives, process for producing the same and drugs containing the same as the active ingredient

Kazuhiko Torisu; Tomoyuki Hasegawa; Kaoru Kobayashi; Fumio Nambu

Organic Process Research & Development | 2005

A new process for synthesis of the astrocyte activation suppressor, ONO-2506

Tomoyuki Hasegawa; Yasufumi Kawanaka; Eichi Kasamatsu; Chisa Ohta; Kazuhiro Nakabayashi; Masaki Okamoto; Masaya Hamano; Keiji Takahashi; and Shuichi Ohuchida; Yasumasa Hamada

Organic Process Research & Development | 2003

Process Development of ONO-2506: A Therapeutic Agent for Stroke and Alzheimer's Disease

Tomoyuki Hasegawa; Yasufumi Kawanaka; Eiji Kasamatsu; Yoichi Iguchi; Yoshihira Yonekawa; Masaki Okamoto; Chiaki Ohta; Shinsuke Hashimoto; Shuichi Ohuchida

Synlett | 1998

A PRACTICAL REMOVAL METHOD OF CAMPHORSULTAM

Tomoyuki Hasegawa; Hisashi Yamamoto

Archive | 2004

Branched carboxylic acid compound and use thereof

Haruo Imawaka; Tomoyuki Hasegawa; Shigeru Sakuyama; Yasufumi Kawanaka; Tsutomu Akiyama; Masamitsu Hoshikawa; Saiko Matsuda

Archive | 2004

Process for producing (2r)-2-propyloctanoic acid and intermediate therefor

Yasumasa Hamada; Tomoyuki Hasegawa; Toshiaki Matsui; Eiji Kasamatsu

Synlett | 1999

A Selective Partial Hydrolysis of Dimenthyl Ester Using Dry Tetrabutylammonium Hydroxide

Tomoyuki Hasegawa; Hisashi Yamamoto

Archive | 2005

CRYSTAL COMPRISING (2R)-2-PROPYLOCTANOIC ACID AND AMINE

Tomoyuki Hasegawa; Yasufumi Kawanaka; Eiji Kasamatsu

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Toshiaki Matsui

Nagoya City University

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Shin Saito

Mie Prefectural College of Nursing

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Yasufumi Kawanaka

Tokyo Institute of Technology

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Hisashi Yamamoto

Chubu University

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Kaoru Kobayashi

Chiba University

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Masaki Okamoto

Osaka City University

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Shuichi Ohuchida

Kyoto University

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Yasumasa Hamada

Nagoya City University

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Atsushi Naganawa

Nagoya University

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Hiromu Egashira

Kyushu University

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