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Toshiyuki Kohara

Mitsubishi

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Publication

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Bioorganic & Medicinal Chemistry Letters | 1995

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

Kunitomo Adachi; Toshiyuki Kohara; Noriyoshi Nakao; Masafumi Arita; Kenji Chiba; Tadashi Mishina; Shigeo Sasaki; Tetsuro Fujita

FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride), a novel synthetic immunosuppressant led by modification of ISP-I (myriocin, thermozymocidin) displayed potent immunosuppressive activity both in vitro and in vivo.

Bioorganic & Medicinal Chemistry Letters | 1998

Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720

Masatoshi Kiuchi; Kunitomo Adachi; Toshiyuki Kohara; Koji Teshima; Yumi Masubuchi; Tadashi Mishina; Tetsuro Fujita

Desymmerization of symmetric FTY720 by substitution of different alkyl groups for one of the prochiral hydroxymethyl groups was performed. The size of the alkyl groups and the absolute configuration at quaternary carbon were important on immunosuppressive activity.

Journal of Medicinal Chemistry | 2000

Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols.

Masatoshi Kiuchi; Kunitomo Adachi; Toshiyuki Kohara; Masanori Minoguchi; Tokushi Hanano; Yoshiyuki Aoki; Tadashi Mishina; Masafumi Arita; Noriyoshi Nakao; Makio Ohtsuki; Yukio Hoshino; Koji Teshima; Kenji Chiba; Shigeo Sasaki; Tetsuro Fujita

Archive | 1999

Benzene compound and pharmaceutical use thereof

Tetsuro Fujita; Kunitomo Adachi; Toshiyuki Kohara; Masatoshi Kiuchi; Kenji Chiba; Koji Teshima; Tadashi Mishina

Archive | 2004

BI-ARYL COMPOUND HAVING IMMUNOSUPPRESSIVE ACTIVITY

Toshiyuki Kohara; Kunitomo Adachi; Yoshihito Tanaka; Kunio Sugahara; Ayumi Tomatsu; Masatoshi Kiuchi

Journal of Heterocyclic Chemistry | 2002

Synthesis of thieno[2,3-b][1,5]benzoxazepine derivatives

Toshiyuki Kohara; Hiroshi Tanaka; Koreichi Kimura; Hideki Horiuchi; Kohji Seio; Masafumi Yoshitomi Phar. Ind. Ltd. Arita; Tetsuya Fujimoto; Iwao Yamamoto

Chemical & Pharmaceutical Bulletin | 2002

Y-931, a Novel Atypical Antipsychotic Drug, Is Less Sensitive to Oxidative Phenomena

Toshiyuki Kohara; Toshiki Koyama; Masatake Fujimura; Hiroshi Tanaka; Junichi Maeda; Tetsuya Fujimoto; Iwao Yamamoto; Masafumi Yoshitomi Phar. Ind. Ltd. Arita

Archive | 1995

Benzolderivate und deren medizinische verwendung Benzene derivatives and their medical use

Tetsuro Fujita; Kunitomo Adachi; Toshiyuki Kohara; Masatoshi Kiuchi; Kenji Chiba; Koji Teshima; Tadashi Mishina

Archive | 1995

Benzene compounds and the pharmaceutical use of these

Tetsuro Fujita; Kunitomo Adachi; Toshiyuki Kohara; Masatoshi Kiuchi; Kenji Chiba; Koji Yoshitomi Pharmac Teshima; Tadashi Yoshitomi Phar Mishina

Archive | 1995

Benzene compound and medicinal use.

Tetsuro Fujita; Kunitomo Adachi; Toshiyuki Kohara; Masatoshi Kiuchi; Kenji Chiba; Koji Teshima

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Collaboration

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Kunitomo Adachi

University of Tokyo

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Masatoshi Kiuchi

Kyoto University

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Tetsuro Fujita

Mitsubishi

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Kenji Chiba

Mitsubishi Tanabe Pharma

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Koji Teshima

Mitsubishi

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Tadashi Mishina

Mitsubishi

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Hiroshi Tanaka

Mitsubishi

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Iwao Yamamoto

Shinshu University

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Masafumi Arita

University of Tokyo

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Masafumi Yoshitomi Phar. Ind. Ltd. Arita

Mitsubishi

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