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Masatoshi Kiuchi

Kyoto University

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Publication

Featured researches published by Masatoshi Kiuchi.

Bioorganic & Medicinal Chemistry Letters | 1995

Simple compounds, 2-alkyl-2-amino-1,3-propanediols have potent immunosuppressive activity

Tetsuro Fujita; Masahiko Yoneta; Ryoji Hirose; Shigeo Sasaki; Kenichiro Inoue; Masatoshi Kiuchi; Susumu Hirase; Kunitomo Adachi; Masafumi Arita; Kenji Chiba

Abstract ISP-I (myriocin, thermozymocidin) was structurally simplified to give 2-amino-2-alkyl-1,3-propanediols that were also potent immunosuppressants. Among the series, 2-amino-2-pentadecyl-1,3-propanediol most actively prolonged rat skin allograft survival and was more effective than ciclosporin.

Bioorganic & Medicinal Chemistry Letters | 1998

Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720

Masatoshi Kiuchi; Kunitomo Adachi; Toshiyuki Kohara; Koji Teshima; Yumi Masubuchi; Tadashi Mishina; Tetsuro Fujita

Desymmerization of symmetric FTY720 by substitution of different alkyl groups for one of the prochiral hydroxymethyl groups was performed. The size of the alkyl groups and the absolute configuration at quaternary carbon were important on immunosuppressive activity.

Journal of Medicinal Chemistry | 2000

Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols.

Masatoshi Kiuchi; Kunitomo Adachi; Toshiyuki Kohara; Masanori Minoguchi; Tokushi Hanano; Yoshiyuki Aoki; Tadashi Mishina; Masafumi Arita; Noriyoshi Nakao; Makio Ohtsuki; Yukio Hoshino; Koji Teshima; Kenji Chiba; Shigeo Sasaki; Tetsuro Fujita

Journal of Medicinal Chemistry | 1996

Potent immunosuppressants, 2-alkyl-2-aminopropane-1,3-diols

Tetsuro Fujita; Ryoji Hirose; Masahiko Yoneta; Shigeo Sasaki; Kenichiro Inoue; Masatoshi Kiuchi; Susumu Hirase; Kenji Chiba; Hiroshi Sakamoto; Masafumi Arita

The Journal of Antibiotics | 1994

FUNGAL METABOLITES. PART 14†. NOVEL POTENT IMMUNOSUPPRESSANTS, MYCESTERICINS, PRODUCED BY Mycelia sterilia

Shgeo Sasaki; Ryouta Hashimoto; Masatoshi Kiuchi; Kenichiro Inoue; Takeshi Ikumoto; Ryoji Hirose; Kenji Chiba; Yukio Hoshino; Takeki Okumoto; Tetsuro Fujita

Archive | 1999

Benzene compound and pharmaceutical use thereof

Tetsuro Fujita; Kunitomo Adachi; Toshiyuki Kohara; Masatoshi Kiuchi; Kenji Chiba; Koji Teshima; Tadashi Mishina

The Journal of Antibiotics | 1996

Determination of Absolute Configuration and Biological Activity of New Immunosuppressants, Mycestericins D, E, F and G

Tetsuro Fujita; Norimitsu Hamamichi; Masatoshi Kiuchi; Tohru Matsuzaki; Yuki Kitao; Kenichiro Inoue; Ryoji Hirose; Masahiko Yoneta; Shigeo Sasaki; Kenji Chba

Journal of Medicinal Chemistry | 2010

Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate.

Maiko Hamada; Mitsuharu Nakamura; Masatoshi Kiuchi; Kaoru Marukawa; Ayumi Tomatsu; Kyoko Shimano; Noriko Sato; Kunio Sugahara; Mahoko Asayama; Kan Takagi; Kunitomo Adachi

Archive | 2004

BI-ARYL COMPOUND HAVING IMMUNOSUPPRESSIVE ACTIVITY

Toshiyuki Kohara; Kunitomo Adachi; Yoshihito Tanaka; Kunio Sugahara; Ayumi Tomatsu; Masatoshi Kiuchi

Tetrahedron Letters | 1995

DETERMINATION OF THE ABSOLUTE CONFIGURATIONS AND TOTAL SYNTHESIS OF NEW IMMUNOSUPPRESSANTS, MYCESTERICINS E AND G

Tetsuro Fuiita; Norimitsu Hamamichi; Tohru Matsuzaki; Yuki Kitao; Masatoshi Kiuchi; Manabu Node; Ryoji Hiruse

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Kunitomo Adachi

University of Tokyo

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Kunio Sugahara

Mitsubishi

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Tetsuro Fujita

Mitsubishi

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Kenji Chiba

Mitsubishi Tanabe Pharma

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Maiko Hamada

Mitsubishi Tanabe Pharma

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Toshiyuki Kohara

Mitsubishi

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Koji Teshima

Mitsubishi

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Tadashi Mishina

Mitsubishi

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Kenichiro Inoue

Kyoto University

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Ryoji Hirose

Mitsubishi

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