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Featured researches published by Tsutomu Kaneko.


Current Microbiology | 1996

Inhibition of bacterial translocation from the gastrointestinal tract of mice injected with cyclophosphamide.

Takuya Suzuki; Kikuji Itoh; Takehiro Hagiwara; Hiroyuki Nakayama; Kazuhito Honjyo; Yoshikazu Hirota; Tsutomu Kaneko; Hideki Suzuki

Abstract. Effects of intraperitoneal injection of cyclophosphamide, an immunosuppressant, on the degree of bacterial translocation and morphological changes of Peyers patches (PP) in the intestine were investigated with antibiotic-decontaminated SPF mice and germfree mice monoassociated with Escherichia coli C25. It has been reported that treatment with cyclophosphamide induces bacterial translocation. Cyclophosphamide treatment in this study, however, significantly decreased E. coli C25 translocation from the gastrointestinal tract to the mesenteric lymph nodes (MLN), although the numbers of lymphoid cells, especially B cells, in the PP, MLN, and spleen were remarkably reduced. Four injections of cyclophosphamide at a dose of 100 mg/kg inhibited bacterial translocation more than one injection at a dose of 200 mg/kg in SPF mice. Germfree mice, however, treated with one dose of 200 mg/kg showed the same inhibition of bacterial translocation as those given 100 mg/kg four times. In cyclophosphamide-treated mice, lymph follicles in the PP were obviously smaller than those in control mice, M-cells were similar in appearance to absorption epithelial cells except for short microvilli, and immune cells among the M-cells had disappeared. These data suggested that inhibition of bacterial translocation in mice treated with cyclophosphamide may be the result of morphological and physiological changes of epithelial cells in the gastrointestinal tract, especially M-cells, as a point of entry of invading bacteria, independent of the changes in immunological function.


Archive | 1994

Improvement of Bread Flavor by a Dairy Substrate Treated with Enzymes and Lactic Acid Bacteria

Masashi Yamamoto; Reiko Watanabe; Tsutomu Kaneko; Hideki Suzuki

Iso-amylalcohol (iso-AmOH), iso-butylalcohol (iso-BuOH) and ethylcaprylate (EtOcapry) were the main aroma components in bread, and the content of these components with a dairy substrate treated with several enzymes and fermented with lactic acid bacteria (FCT) increased from 1.2 to 1.6 times those of control bread. The increase in iso-AmOH and iso-BuOH content in bread with FCT appeared due to increased leucine and valine content in dough by adding FCT. The increase in EtOcapry content may have been caused by the caprylic acid found in FCT. The addition of the hydrolysate of milk protein and milk fat to dough is thus shown to greatly improve bread flavor.


Journal of Dairy Science | 1994

Growth Stimulator for Bifidobacteria Produced by Propionibacterium freudenreichii and Several Intestinal Bacteria

Tsutomu Kaneko; Hiroharu Mori; Megumi Iwata; Sachiko Meguro


Applied and Environmental Microbiology | 1990

Acetoin Fermentation by Citrate-Positive Lactococcus lactis subsp. lactis 3022 Grown Aerobically in the Presence of Hemin or Cu2+

Tsutomu Kaneko; Masahiro Takahashi; Hideki Suzuki


Journal of Veterinary Medical Science | 1997

Inhibition of Bacterial Translocation from the Gastrointestinal Tract of Mice by Oral Administration of a Culture Condensate of Bifidobacterium longum

Takuya Suzuki; Kikuji Itoh; Tsutomu Kaneko; Hideki Suzuki


Journal of Dairy Science | 1990

Enhancement of Diacetyl Production by a Diacetyl-Resistant Mutant of Citrate-Positive Lactococcus lactis ssp. lactis 3022 and by Aerobic Conditions of Growth

Tsutomu Kaneko; Yukari Watanabe; Hideki Suzuki


Journal of Dairy Science | 1997

Digoxigenin-labeled deoxyribonucleic acid probes for the enumeration of bifidobacteria in fecal samples

Tsutomu Kaneko; Hiroko Kurihara


Archive | 1990

Method for the fermentative production of diacetyl and acetoin using lactic acid bacterium

Tsutomu Kaneko; Masahiro Takahashi; Hideki Suzuki


Applied and Environmental Microbiology | 1991

Differences between Lactobacillus casei subsp. casei 2206 and Citrate-Positive Lactococcus lactis subsp. lactis 3022 in the Characteristics of Diacetyl Production

Tsutomu Kaneko; Yukari Watanabe; Hideki Suzuki


Agricultural and biological chemistry | 1986

Diacetyl Formation and Degradation by Streptococcus lactis subsp. diacetylactis 3022

Tsutomu Kaneko; Hideki Suzuki; Tsuyoshi Takahashi

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Yoshikazu Hirota

Tokyo University of Agriculture and Technology

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