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Dive into the research topics where Yalcin Erzurumlu is active.

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Featured researches published by Yalcin Erzurumlu.


The International Journal of Biochemistry & Cell Biology | 2013

A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization.

Yalcin Erzurumlu; Fadime Aydin Kose; Oguz Gozen; Devrim Gozuacik; Eric A. Toth; Petek Ballar

p97/VCP is a hexameric AAA type ATPase that functions in a variety of cellular processes such as endoplasmic reticulum associated degradation (ERAD), organelle biogenesis, autophagy and cell-cycle regulation. Inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia (IBMPFD) is an autosomal dominant disorder which has been attributed to mutations in p97/VCP. Several missense mutations affecting twelve different amino acids have been identified in IBMPFD patients and some of them were suggested to be involved in the observed pathology. Here, we analyzed the effect of all twelve p97/VCP variants on ERAD substrates and their cofactor binding abilities. While all mutants cause ERAD substrate accumulation, P137L mutant p97/VCP differs from other IBMPFD mutants by having a unique solubility profile and subcellular localization. Intriguingly, although almost all mutants exhibit enhanced p47 and Ufd1-Npl4 binding, the P137L mutation completely abolishes p97/VCP interactions with Ufd1, Npl4 and p47, while retaining its gp78 binding. While recombinant R155C mutant protein consistently interacts with both Ufd1 and VIM of gp78, P137L mutant protein lost binding ability to Ufd1 but not to VIM in vitro. The differential impairments in p97/VCP interactions with its functional partners and function should help our understanding of the molecular pathogenesis of IBMPFD.


Scientific Reports | 2017

Androgen Mediated Regulation of Endoplasmic Reticulum-Associated Degradation and its Effects on Prostate Cancer

Yalcin Erzurumlu; Petek Ballar

The endoplasmic reticulum (ER) comprises thirty percent of the newly translated proteins in eukaryotic cells. The quality control mechanism within the ER distinguishes between properly and improperly folded proteins and ensures that unwanted proteins are retained in the ER and subsequently degraded through ER-associated degradation (ERAD). Besides cleaning of misfolded proteins ERAD is also important for physiological processes by regulating the abundance of normal proteins of the ER. Thus it is important to unreveal the regulation patterns of ERAD. Here, we describe that ERAD pathway is regulated by androgen, where its inhibitor SVIP was downregulated, all other ERAD genes were upregulated. Consistently, androgen treatment increased the degradation rate of ERAD substrates. Using several independent techniques, we showed that this regulation is through androgen receptor transactivation. ERAD genes found to be upregulated in prostate cancer tissues and silencing expression of Hrd1, SVIP, and gp78 reduced the in vitro migration and malignant transformation of LNCaP cells. Our data suggests that expression levels of ERAD components are regulated by androgens, that promotes ERAD proteolytic activity, which is positively related with prostate tumorigenesis.


Atlas of genetics and cytogenetics in oncology and haematology | 2012

AMFR (autocrine motility factor receptor)

Yalcin Erzurumlu; Petek Ballar

Review on AMFR (autocrine motility factor receptor), with data on DNA, on the protein encoded, and where the gene is implicated.


Chemical Biology & Drug Design | 2018

Synthesis and evaluation of pyridinium-hydrazone derivatives as potential antitumoral agents

Sülünay Parlar; Yalcin Erzurumlu; Recep Ilhan; Petek Ballar Kirmizibayrak; Vildan Alptüzün; Ercin Erciyas

The hydrazones of 4‐hydrazinylpyridinium bearing alkylphenyl groups on pyridinium nitrogen were synthesized and evaluated for their cytotoxic activity against MCF‐7, PC3, U2OS, and HEK293 cell lines by Wst1 cell proliferation assay. Cytotoxic activity results indicated that d derivatives having butylene chain; 4 and 5 series having naphthalene and anthracene ring systems showed high cytotoxic activity (IC50 = 3.27–8.54 μm) on cancer cells. 3d (4‐(2‐(4‐hydroxybenzylidene)hydrazinyl)‐1‐(4‐phenylbutyl)pyridinium bromide) was the most cytotoxic compound with IC50 value of 3.27 μm against MCF‐7. The most active derivatives (1d, 2d, 3d, 4, and 5 series) were selected to investigate for the effects on autophagy by analyzing the expression of autophagy marker proteins. The conversion of LC3‐I to its lipidated form LC3‐II is essential for autophagy and related to autophagosomes. According to our results, all tested compounds except for 3d induced lipidated form LC3‐II accumulation. Then, the effects of the compounds on p62 protein level were also analyzed by the immunoblotting as the autophagy inhibition results in accumulation of p62. Further molecular mechanistic studies including morphological analysis and live–death assays indicated that all tested compounds (1d, 2d, 3d, 4, and 5 series) are potent antitumoral molecules and all except for 3d have potential to inhibit autophagic flux.


Atlas of genetics and cytogenetics in oncology and haematology | 2013

VCP (valosin containing protein)

Yalcin Erzurumlu; Recep Ilhan; Oguz Gozen; Petek Ballar

Review on VCP (valosin containing protein), with data on DNA, on the protein encoded, and where the gene is implicated.


Letters in Drug Design & Discovery | 2014

Evaluation of Alkylating and Intercalating Properties of Mannich Bases for Cytotoxic Activity

Huseyin Istanbullu; Yalcin Erzurumlu; Petek Ballar Kirmizibayrak; Ercin Erciyas


Journal of Electroanalytical Chemistry | 2016

Electrochemical aptasensor design for label free cytosensing of human non-small cell lung cancer

P. Kara; Yalcin Erzurumlu; P. Ballar Kirmizibayrak; Mehmet Ozsoz


Archive | 2012

Introduction to Molecular Biology Related to Electrochemical DNA-Based Biosensors

Yalcin Erzurumlu; Petek Ballar


Archive | 2017

Effect of a New Sapogenol Derivative (AG-07) on Cell Death via Necrosis

Yalcin Erzurumlu; Özgür Tağ; Sinem Yılmaz; Petek Ballar; Erdal Bedir


Free Radical Biology and Medicine | 2018

Potential protective effects of hydroxypropyl-β-cyclodextrin on Aβ (1–42)-induced neurotoxicity

Ayfer Yalcin; Ezgi Turunc; Yiğit Uyanıkgil; Lutfiye Kanit; Mehmet M. Kaplan; Yalcin Erzurumlu; Ege Sevinc

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