Yamagishi S
Hokuriku University
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Publication
Featured researches published by Yamagishi S.
Journal of Biological Chemistry | 2002
Yamagishi S; Yosuke Inagaki; Tamami Okamoto; Shinjiro Amano; Kohachiro Koga; Masayoshi Takeuchi; Zenji Makita
Advanced glycation end products (AGE) have been implicated in the pathogenesis of glomerulosclerosis in diabetes. However, their involvement in the development of the early phase of diabetic nephropathy has not been fully elucidated. We investigated the effects of AGE on growth and on vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1) expression in human cultured mesangial cells. We prepared three immunochemically distinct AGE by incubating bovine serum albumin (BSA) with glucose, glyceraldehyde, or glycolaldehyde. When human mesangial cells were cultured with various types of AGE-BSA, viable cell numbers as well as DNA syntheses were significantly decreased. All of the AGE-BSA were found to significantly increase p53 and Bax protein accumulations and subsequently induce apoptotic cell death in mesangial cells. An antioxidant, N-acetylcysteine, significantly prevented the AGE-induced apoptotic cell death in mesangial cells. Human mesangial cells stimulated prostacyclin production by co-cultured glomerular endothelial cells. Furthermore, various types of AGE-BSA were found to up-regulate the levels of mRNAs for VEGF and stimulate the secretion of VEGF and MCP-1 proteins in mesangial cells. The results suggest that AGE disturbed glomerular homeostasis by inducing apoptotic cell death in mesangial cells and elicited hyperfiltration and microalbuminuria by stimulating the secretion of VEGF and MCP-1 proteins, thereby being involved in the pathogenesis of the early phase of diabetic nephropathy.
Kidney International | 2003
Yamagishi S; Yosuke Inagaki; Tamami Okamoto; Shinjiro Amano; Kohachiro Koga; Masayoshi Takeuchi
International Journal of Clinical Pharmacology Research | 2003
Yamagishi S; Masayoshi Takeuchi; Yosuke Inagaki; Kei-ichiro Nakamura; T. Imaizumi
Drugs Under Experimental and Clinical Research | 2004
Yamagishi S; Masayoshi Takeuchi
International Journal of Clinical Pharmacology Research | 2002
Kohachiro Koga; Yamagishi S; Tamami Okamoto; Yosuke Inagaki; Shinjiro Amano; Masayoshi Takeuchi; Zenji Makita
International Journal of Tissue Reactions-experimental and Clinical Aspects | 2002
Yamagishi S; Yosuke Inagaki; Shinjiro Amano; Tamami Okamoto; Masayoshi Takeuchi
Drugs Under Experimental and Clinical Research | 2003
Yamagishi S; Yosuke Inagaki; Seiji Kikuchi
International Journal of Tissue Reactions-experimental and Clinical Aspects | 2005
Yamagishi S; Takanori Matsui; Kei-ichiro Nakamura; Masayoshi Takeuchi
International Journal of Clinical Pharmacology Research | 2004
Yamagishi S; Kei-ichiro Nakamura; Masayoshi Takeuchi; T. Imaizumi
International Journal of Tissue Reactions-experimental and Clinical Aspects | 2003
Shinjiro Amano; Yamagishi S; Yosuke Inagaki; Tamami Okamoto