Yandi Syukri

Implementation of cooperative learning through collaboration with foreign lecturer to improve students’ understanding and soft skills in the course of drug delivery system

The course of Drug Delivery Systems is an elective that supports the development of new products in pharmaceutical industry. The existing learning process has been in the form of one-direction face-to-face lecturing. During the lecture, students find it difficult to follow or understand the materials, so they become passive. Also, class effectiveness is low because it cannot develop students’ active participation during the learning process. To improve the learning outcomes and to achieve the desired competence, innovations in the learning process should be attempted. This learning model aimed to improve students’ understanding of and soft skills in the course of Drug Delivery Systems through a cooperative learning method and collaboration with foreign lecturers. The order of cooperative learning included explaining the desired learning outcomes of each topic, providing reading materials for students to learn when preparing their papers, instructing students to work on group assignments and to help each o...

UJI DISINTEGRASI DAN DISOLUSI TERBANDING TABLET ALOPURINOL GENERIK BERMEREK DAN GENERIK BERLOGO YANG BEREDAR DI PASARAN

ABSTRACT Allopurinol is a pyrimidine derivative that effective to normalize levels of uric acid in blood and urine. Allopurinol is very slightly soluble in water, but it has high permeability (BCS class II) so that the dissolution is an important determine to express the drug bioavailability. Additional material differences and the production process of each plant can cause differences in the quality of the resulting allopurinol tablets. This study aimed to compare the quality of branded generic and generic products allopurinol tablets in the quality of disintegration and dissolution. This study used 5 kinds branded generic (A, B, C, D, E) and 5 kinds of generic products (F, G, H, I, J). Disintegration test carried out according to USP-NF 32 nd edition by the medium of water at 37 ± 2°C. Dissolution tests conducted according to USP-NF 32 nd edition using apparatus 2 (paddle methode), the speed of rotation 75 rpm, in 0.01 N HCl medium at 37 ± 0.5°C. The data obtained compared with the requirements listed in the Indonesia Pharmacopoeia 4 th edition and USP-NF 32 nd edition, and then statistically analyzed by T test at 95% confidence interval. Results of disintegration and dissolution tests met the requirements in the literature. Statistical test results showed that products had different disintegration and dissolution profile. Keywords: allopurinol, disintegration, dissolution, tablets

A COMPARATIVE BIOAVAILABILITY OF FUROSEMIDE IN SOLID DISPERSIONS FORMS

Furosemide is a poorly soluble diuretic drug, the solubility of which can be enhanced by solid dispersion with polyvinylpirolidon (PVP). The solid dispersion system was prepared by a solvent method in various ratios of 1 : 5 and 1 : 7 of the drug and PVP, respectively, in order to improve furosemide bioavailability. The bioavailability of furosemide - PVP solid dispersion was compared with pure furosemide (control) and Lasix (reference). The study was done in a cross over design with a single-dose peroral that administered to the white male rabbits (n = 6). Furosemide blood levels were determined spectrofluorometrically by an extraction method. The area under the blood concentration-time curve AUC0 - , peak blood concentration Cmax and time to reach peak blood concentration Tmax were used to compare their bioavailabilities. The solid dispersion systems produced a higher extent of bioavailability than pure furosemide (P 0,05). Finally, furosemide – PVP solid dispersion (1 : 7) was the best formulation with the highest extent of bioavailability and bioequivalence with the Lasix formula. Key Word : Solid dispersion, solubility, dissolution, bioavailability, furosemide.