Yoshinobu Satoh

ULTRASOUND-GUIDED MICROWAVE THERMOTHERAPY ON A VX-2 CARCINOMA IMPLANTED IN RABBIT KIDNEY

A temperature greater than 60 degrees C was maintained for 60 s within a 5-mm radius of a microwave electrode implanted in a rabbit kidney using 2450 MHz at 100 W for 30 s. Histological examination revealed complete coagulation necrosis in that area. VX-2 cells were inoculated into the kidneys of 10 rabbits. One week later, five rabbits received ultrasound-guided microwave thermotherapy, and the remaining five rabbits received no treatment. All rabbits with microwave thermotherapy had a complete response to treatment while all rabbits without therapy died of cancer within 6 weeks of the VX-2 implantation. These results indicate that ultrasound-guided microwave thermotherapy has the potential of being a nephron-salvaging treatment for small renal tumors.

EXPERIMENTAL STUDY OF MICROWAVE COAGULATION OF A VX-2 CARCINOMA IMPLANTED IN RABBIT KIDNEY

This paper describes the results of an experimental study of the microwave coagulation of VX‐2 renal tumors implanted in rabbits. The rabbits undergoing microwave treatment exhibited a satisfactory survival rate and a complete response to treatment, as verified by histological examination. All the rabbits receiving no treatment died within 6 weeks of implantation of the VX‐2 carcinoma. These results indicate that microwave coagulation may be a curative method of treatment for a relatively small renal tumor. Intraoperative real‐time ultrasonic scanning permits the percutaneous microwave coagulation of renal cancer in a clinical situation.

Intraoperative real-time ultrasonic scanning for microwave coagulation of the prostate

Nine patients with severe dysuria caused by prostatic cancer received prostatic microwave coagulation under intraoperative real-time ultrasonic scanning. During the procedure, the microwave applicator was clearly observed, and the coagulation region appeared as an hyperechoic area compared to the noncoagulated region. Intraoperative real-time ultrasonic scanning allowed safer and more efficacious application of prostatic microwave coagulation.

Urinary basic fetoprotein in the diagnosis and follow‐up of patients with urothelial carcinoma

Urothelial carcinoma is one of the most common malignant neoplasms of the urinary tract and is characterized by a high local recurrence rate. However, no specific and reliable tumor marker has been identified for the diagnosis and follow‐up of patients with urothelial carcinoma.

A case of transurethral microwave coagulation therapy for urinary bladder diverticulum

We applied transurethral microwave coagulation therapy to urinary bladder diverticulum. The case is 71-year-old female who had two large diverticulums, 11 × 9 × 7 cm in size on the right lateral wall and 5 × 5 × 4 cm in size on the anterior wall. Electrode resection of diverticular neck was performed, and then all of the inside mucosa was coagulated with a microwave energy of 100 watts. This procedure was able to be performed safely to the end without any complications. After the operation, both diverticulums disappeared. It supposed that the transurethral microwave coagulation therapy was a useful procedure for the endoscopic treatment of urinary bladder diverticulum.