Akiko Orita
Astellas Pharma
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Publication
Featured researches published by Akiko Orita.
Immunology Letters | 1997
Ken Ikeda; Masako Hirano; Akiko Orita; Makoto Takeuchi
We investigated the effect of chlorpromazine (CPZ) in a murine model of T-cell-dependent liver injury caused by concanavalin A (ConA). CPZ (3 and 10 mg/kg) treatment 1 h before ConA injection prevented liver injury. CPZ (3, 10 mg/kg) administered 1 h after a ConA injection was also hepatoprotective, whereas cyclosporin (CsA, 100 mg/kg) was active only when given before ConA. Under either condition, CsA but not CPZ prevented concurrent increases in splenic ornithine decarboxylase (ODC) activity, a putative index of T-cell proliferation/differentiation. CPZ down-regulated tumor necrosis factor-alpha (TNF-alpha) and up-regulated IL-10 in mice that then received ConA, whereas delayed administration of CPZ had no effect. These results suggest that CPZ prevented liver injury without affecting the proliferation/differentiation of T-cells. The dissociation of hepatoprotection by CPZ from cytokine modulation indicates that this drug intervenes in the adherence of T-cells or the death of hepatocytes in the ConA-model.
Archive | 1998
Hiroyuki Hisamichi; Ryo Naito; Souichirou Kawazoe; Akira Toyoshima; Kazuhito Tanabe; Eiichi Nakai; Atsushi Ichikawa; Akiko Orita; Makoto Takeuchi
Archive | 1998
Hiroyuki Hisamichi; Ryo Naito; Souichirou Kawazoe; Akira Toyoshima; Kazuhito Tanabe; Eiichi Nakai; Atsushi Ichikawa; Akiko Orita; Makoto Takeuchi
Bioorganic & Medicinal Chemistry | 2005
Hiroyuki Hisamichi; Ryo Naito; Akira Toyoshima; Noriyuki Kawano; Atsushi Ichikawa; Akiko Orita; Masaya Orita; Noritaka Hamada; Makoto Takeuchi; Mitsuaki Ohta; Shin-ichi Tsukamoto
Archive | 2000
Hiroyuki Hisamichi; Atsushi Ichikawa; Souichirou Yamanouchi Pharma. Co. Ltd. Kawazoe; Kenichi Onda; Akiko Orita; Takayuki Suzuki; Makoto Yamanouchi Pharma. Co. Ltd. Takeuchi; Kazuhito Tanabe
Archive | 2000
Atsushi Ichikawa; Soichiro Kawazoe; Hiroyuki Kudo; Kenichi Onda; Akiko Orita; Takayuki Suzuki; Makoto Takeuchi; Kazuhito Tanabe; 弘幸 久道; 聡一郎 川添; 敦 市川; 健一 恩田; 明子 折田; 一仁 田邉; 誠 竹内; 貴之 鈴木
Bioorganic & Medicinal Chemistry | 2005
Hiroyuki Hisamichi; Ryo Naito; Akira Toyoshima; Noriyuki Kawano; Atsushi Ichikawa; Akiko Orita; Masaya Orita; Noritaka Hamada; Makoto Takeuchi; Mitsuaki Ohta; Shin-ichi Tsukamoto
Archive | 2005
Takeuchi Makoto; Ichikawa Atsushi; Suzuki Takayuki; Kawazoe Souichirou; Onda Kenichi; Hiroyuki Hisamichi; Kazuhito Tanabe; Akiko Orita
Archive | 2000
Hiroyuki Hisamichi; Atsushi Ichikawa; Souichirou Yamanouchi Pharma. Co. Ltd. Kawazoe; Kenichi Onda; Akiko Orita; Takayuki Suzuki; Makoto Yamanouchi Pharma. Co. Ltd. Takeuchi; Kazuhito Tanabe
Archive | 2000
Hiroyuki Hisamichi; Atsushi Ichikawa; Souichirou Yamanouchi Pharma. Co. Ltd. Kawazoe; Kenichi Onda; Akiko Orita; Takayuki Suzuki; Makoto Yamanouchi Pharma. Co. Ltd. Takeuchi; Kazuhito Tanabe