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Akira Toyoshima

Astellas Pharma

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Publication

Featured researches published by Akira Toyoshima.

Journal of Medicinal Chemistry | 2005

Synthesis and Antimuscarinic Properties of Quinuclidin-3-yl 1,2,3,4-Tetrahydroisoquinoline-2-carboxylate Derivatives as Novel Muscarinic Receptor Antagonists1

Ryo Naito; Yasuhiro Yonetoku; Yoshinori Okamoto; Akira Toyoshima; Ken Ikeda; Makoto Takeuchi

Archive | 1998

Novel pyrimidine-5-carboxamide derivatives

Hiroyuki Hisamichi; Ryo Naito; Souichirou Kawazoe; Akira Toyoshima; Kazuhito Tanabe; Eiichi Nakai; Atsushi Ichikawa; Akiko Orita; Makoto Takeuchi

Archive | 1998

Pyrimidine-5-carboxamide derivatives

Hiroyuki Hisamichi; Ryo Naito; Souichirou Kawazoe; Akira Toyoshima; Kazuhito Tanabe; Eiichi Nakai; Atsushi Ichikawa; Akiko Orita; Makoto Takeuchi

Bioorganic & Medicinal Chemistry | 2005

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives

Hiroyuki Hisamichi; Ryo Naito; Akira Toyoshima; Noriyuki Kawano; Atsushi Ichikawa; Akiko Orita; Masaya Orita; Noritaka Hamada; Makoto Takeuchi; Mitsuaki Ohta; Shin-ichi Tsukamoto

Bioorganic & Medicinal Chemistry | 2006

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: Synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamides

Yasuhiro Yonetoku; Hirokazu Kubota; Yoshinori Okamoto; Akira Toyoshima; Masashi Funatsu; Jun Ishikawa; Makoto Takeuchi; Mitsuaki Ohta; Shin-ichi Tsukamoto

Archive | 2001

Propane-1,3-dione derivative

Masaaki Hirano; Eiji Kawaminami; Akira Toyoshima; Hiroyuki Moritomo; Norio Seki; Ryutaro Wakayama; Minoru Okada; Toshiyuki Kusayama

Archive | 1998

Pharmaceutical compound comprising a pyrazole derivative and methods of using the same for the treatment of calcium release-activated calcium channel associated diseases

Hirokazu Kubota; Yasuhiro Yonetoku; Keizou Sugasawa; Masashi Funatsu; Souichirou Kawazoe; Akira Toyoshima; Yoshinori Okamoto; Jun Ishikawa; Makoto Takeuchi

Journal of Medicinal Chemistry | 2006

(+)-(2R,5S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6-(trifluoromethyl)pyridin-3-yl]piperazine-1-carboxamide (YM580) as an orally potent and peripherally selective nonsteroidal androgen receptor antagonist

Isao Kinoyama; Nobuaki Taniguchi; Akira Toyoshima; Eisuke Nozawa; Takashi Kamikubo; Masakazu Imamura; Akira Matsuhisa; Kiyohiro Samizu; Eiji Kawanimani; Tatsuya Niimi; Noritaka Hamada; Hiroshi Koutoku; Takashi Furutani; Masafumi Kudoh; Minoru Okada; Mitsuaki Ohta; Shin-ichi Tsukamoto

Bioorganic & Medicinal Chemistry | 2005

Corrigendum to “Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives” [Bioorg. Med. Chem. 13 (2005) 4936–4951]

Hiroyuki Hisamichi; Ryo Naito; Akira Toyoshima; Noriyuki Kawano; Atsushi Ichikawa; Akiko Orita; Masaya Orita; Noritaka Hamada; Makoto Takeuchi; Mitsuaki Ohta; Shin-ichi Tsukamoto

Archive | 2001

Propane-1,3-dione derivatives useful as gnrh receptor antagonist

Masaaki Hirano; Eiji Kawaminami; Akira Toyoshima; Hiroyuki Moritomo; Norio Seki; Ryutaro Wakayama; Minoru Okada; Toshiyuki Kusayama

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Makoto Takeuchi

Astellas Pharma

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Minoru Okada

Astellas Pharma

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Souichirou Kawazoe

Astellas Pharma

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Akiko Orita

Astellas Pharma

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Atsushi Ichikawa

Astellas Pharma

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Eiji Kawaminami

Astellas Pharma

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Hirokazu Kubota

Astellas Pharma

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Hiroyuki Moritomo

Astellas Pharma

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Jun Ishikawa

Astellas Pharma

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Masaaki Hirano

Astellas Pharma

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