Ayako Honda
OSI Pharmaceuticals
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Publication
Featured researches published by Ayako Honda.
Bioorganic & Medicinal Chemistry Letters | 2011
Andrew P. Crew; Shripad V. Bhagwat; Hanqing Dong; Mark Bittner; Anna Chan; Xin Chen; Heather Coate; Andrew Cooke; Prafulla C. Gokhale; Ayako Honda; Meizhong Jin; Jennifer Kahler; Christine Mantis; Mark J. Mulvihill; Paula A. Tavares-Greco; Brian Volk; Jing Wang; Douglas S. Werner; Lee D. Arnold; Jonathan A. Pachter; Robert Wild; Neil W. Gibson
The discovery and optimization of a series of imidazo[1,5-a]pyrazine inhibitors of mTOR is described. HTS hits were optimized for potency, selectivity and metabolic stability to provide the orally bioavailable proof of concept compound 4c that demonstrated target inhibition in vivo and concomitant inhibition of tumor growth in an MDA-MB-231 xenograft model.
Archive | 2005
Lee D. Arnold; Cara Cesario; Heather Coate; Andrew Philip Crew; Hanqing Dong; Kenneth Foreman; Ayako Honda; Radoslaw Laufer; An-Hu Li; Kristen Michelle Mulvihill; Mark J. Mulvihill; Anthony Nigro; Bijoy Panicker; Arno G. Steinig; Yingchuan Sun; Qinghua Weng; Douglas S. Werner; Michael J. Wyle; Tao Zhang
Archive | 2006
Xin Chen; Heather Coate; Andrew Philip Crew; Hanqing Dong; Ayako Honda; Mark J. Mulvihill; Paula A. R. Tavares; Jing Wang; Douglas S. Werner; Kristen Michelle Mulvihill; Kam W. Siu; Bijoy Panicker; Apoorba Bharadwaj; Lee D. Arnold; Meizhong Jin; Brian Volk; Quinghua Weng; James David Beard
Bioorganic & Medicinal Chemistry | 2008
Mark J. Mulvihill; Qun-Sheng Ji; Heather Coate; Andrew Cooke; Hanqing Dong; Lixin Feng; Kenneth Foreman; Maryland Rosenfeld-Franklin; Ayako Honda; Gilda Mak; Kristen Michelle Mulvihill; Anthony Nigro; Matthew O’Connor; Caroline Pirrit; Arno G. Steinig; Kam W. Siu; Kathryn M. Stolz; Yingchuan Sun; Paula A. R. Tavares; Yan Yao; Neil W. Gibson
Archive | 2004
Joshua Bolger; Arlindo L. Castelhano; Andrew P. Crew; Hanqing Dong; Ayako Honda; Radoslaw Laufer; An-Hu Li; Kristen Michelle Mulvihill; Li Qiu; Colin Peter Sambrook Smith; Yingchaun Sun; Graham Wynne; Tao Zhang
Synthesis | 2010
An-Hu Li; David J. Beard; Heather Coate; Ayako Honda; Mridula Kadalbajoo; Andrew Kleinberg; Radoslaw Laufer; Kristen Michelle Mulvihill; Anthony Nigro; Pawan Rastogi; Dan Sherman; Kam W. Siu; Arno G. Steinig; Ti Wang; Doug Werner; Andrew P. Crew; Mark J. Mulvihill
Archive | 2011
Xin Chen; Heather Coate; Andrew Philip Crew; Hanqing Dong; Ayako Honda; Mark J. Mulvihill; Paula A. R. Tavares; Jing Wang; Douglas S. Werner; Kam W. Siu; Bijoy Panicker; Apoorba Bharadwaj; Lee D. Arnold; Meizhong Jin; Brian Volk; Quinghua Weng; James David Beard
Archive | 2006
Xin Chen; Heather Coate; Andrew-Philip Crew; Hanqing Dong; Ayako Honda; Mark J. Mulvihill; Paula A. R. Tavares; Jing Wang; Douglas S. Werner; Kristen Michelle Mulvihill; Kam W. Siu; Bijoy Panicker; Apoorba Bharadwaj; Lee D. Arnold; Meizhong Jin; Brian Volk; Qinghua Weng; James David Beard
Archive | 2006
Xin Chen; Heather Coate; Andrew-Philip Crew; Hanqing Dong; Ayako Honda; Mark J. Mulvihill; Paula A. R. Tavares; Jing Wang; Douglas S. Werner; Kristen Michelle Mulvihill; Kam W. Siu; Bijoy Panicker; Apoorba Bharadwaj; Lee D. Arnoldd; Meizhong Jin; Brian Volk; Qinghua Weng; James David Beard
Archive | 2006
Xin Chen; Heather Coate; Andrew-Philip Crew; Hanqing Dong; Ayako Honda; Mark J. Mulvihill; Paula A. R. Tavares; Jing Wang; Douglas S. Werner; Kristen Michelle Mulvihill; Kam W. Siu; Bijoy Panicker; Apoorba Bharadwaj; Lee D. Arnold; Meizhong Jin; Brian Volk; Qinghua Weng; James David Beard
