Brian Volk
OSI Pharmaceuticals
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Publication
Featured researches published by Brian Volk.
Organic and Biomolecular Chemistry | 2007
An-Hu Li; Eilaf Ahmed; Xin Chen; Matthew Cox; Andrew P. Crew; Hanqing Dong; Meizhong Jin; Lifu Ma; Bijoy Panicker; Kam W. Siu; Arno G. Steinig; Kathryn M. Stolz; Paula A. R. Tavares; Brian Volk; Qinghua Weng; Doug Werner; Mark J. Mulvihill
A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66-100%).
Bioorganic & Medicinal Chemistry Letters | 2011
Andrew P. Crew; Shripad V. Bhagwat; Hanqing Dong; Mark Bittner; Anna Chan; Xin Chen; Heather Coate; Andrew Cooke; Prafulla C. Gokhale; Ayako Honda; Meizhong Jin; Jennifer Kahler; Christine Mantis; Mark J. Mulvihill; Paula A. Tavares-Greco; Brian Volk; Jing Wang; Douglas S. Werner; Lee D. Arnold; Jonathan A. Pachter; Robert Wild; Neil W. Gibson
The discovery and optimization of a series of imidazo[1,5-a]pyrazine inhibitors of mTOR is described. HTS hits were optimized for potency, selectivity and metabolic stability to provide the orally bioavailable proof of concept compound 4c that demonstrated target inhibition in vivo and concomitant inhibition of tumor growth in an MDA-MB-231 xenograft model.
Archive | 2006
Xin Chen; Heather Coate; Andrew Philip Crew; Hanqing Dong; Ayako Honda; Mark J. Mulvihill; Paula A. R. Tavares; Jing Wang; Douglas S. Werner; Kristen Michelle Mulvihill; Kam W. Siu; Bijoy Panicker; Apoorba Bharadwaj; Lee D. Arnold; Meizhong Jin; Brian Volk; Quinghua Weng; James David Beard
Bioorganic & Medicinal Chemistry Letters | 2007
Mark J. Mulvihill; Qun-Sheng Ji; Doug Werner; Patricia Anne Beck; Cara Cesario; Andrew Cooke; Matthew Cox; Andrew P. Crew; Hanqing Dong; Lixin Feng; Kenneth Foreman; Gilda Mak; Anthony Nigro; Matthew O’Connor; Lydia Saroglou; Kathryn M. Stolz; Izabela Sujka; Brian Volk; Qinghua Weng; Robin Wilkes
Archive | 2010
Rama Devi Appari; Xin Chen; Ramesh Chilukuri; Andrew P. Crew; Hanqing Dong; Caterina Ferraro; Kenneth Foreman; Ramesh C. Gupta; An Hu Li; Dan Sherman; Kathryn M. Stolz; Brian Volk; Robert Zahler
Archive | 2006
Hanqing Dong; Kenneth Foreman; An-Hu Li; Mark J. Mulvihill; Bijoy Panicker; Arno G. Steinig; Kathryn M. Stolz; Qinghua Weng; Meizhong Jin; Brian Volk; Jing Wang; Ti Wang; James David Beard
Tetrahedron Letters | 2010
Douglas S. Werner; Hanqing Dong; Mridula Kadalbajoo; Radoslaw Laufer; Paula A. Tavares-Greco; Brian Volk; Mark J. Mulvihill; Andrew P. Crew
Archive | 2011
Xin Chen; Heather Coate; Andrew Philip Crew; Hanqing Dong; Ayako Honda; Mark J. Mulvihill; Paula A. R. Tavares; Jing Wang; Douglas S. Werner; Kam W. Siu; Bijoy Panicker; Apoorba Bharadwaj; Lee D. Arnold; Meizhong Jin; Brian Volk; Quinghua Weng; James David Beard
Archive | 2006
Xin Chen; Heather Coate; Andrew-Philip Crew; Hanqing Dong; Ayako Honda; Mark J. Mulvihill; Paula A. R. Tavares; Jing Wang; Douglas S. Werner; Kristen Michelle Mulvihill; Kam W. Siu; Bijoy Panicker; Apoorba Bharadwaj; Lee D. Arnold; Meizhong Jin; Brian Volk; Qinghua Weng; James David Beard
Archive | 2006
Xin Chen; Heather Coate; Andrew-Philip Crew; Hanqing Dong; Ayako Honda; Mark J. Mulvihill; Paula A. R. Tavares; Jing Wang; Douglas S. Werner; Kristen Michelle Mulvihill; Kam W. Siu; Bijoy Panicker; Apoorba Bharadwaj; Lee D. Arnoldd; Meizhong Jin; Brian Volk; Qinghua Weng; James David Beard
