Bing-Kun Ji

Butyrolactones from the Endophytic Fungus Aspergillus versicolor and their Anti-Tobacco Mosaic Virus Activity

New butyrolactones aspernolides C and D, along with two known butyrolactones (A and B) were isolated from the culture of the endophytic fungus Aspergillus versicolor. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D nuclear magnetic ressonance techniques, and electronic circular dichroism. The butyrolactones aspernolides C and D were tested for their anti-tobacco mosaic virus activity. The results showed that butyrolactones aspernolides C and D exhibited moderate anti-tobacco mosaic virus activity with IC50 values of 64.2 and 88.6 μM, respectively.

Dihydroxanthenones from the Fermentation Product of the Endophytic Fungus Gliomastix murorum

Two new dihydroxanthones, muroxanthenones D and E (1 and 2), were isolated from the fermentation products of the endophytic fungus Gliomastix murorum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and they exhibited activity with inhibition rates of 16.4 and 15.3%, respectively.

New Biphenyls from Garcinia multiflora

Three new biphenyls were isolated from Garcinia multiflora. The structures of these biphenyls were elucidated by spectroscopic methods, and their rotavirus activity was evaluated.

Chalcones from Desmodium podocarpum and Their Anti-Tobacco Mosaic Virus Activity

Two new chalcones, podocarchalcones A and B (1 and 2), together with five known chalcones (3–7), were isolated from the whole plants of Desmodium podocarpum. All of their structures were determined by spectroscopic methods including 1D and 2D NMR. Compounds 1–7 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activity, and they exhibited activity with inhibition rates in the range of 15.2–22.4%, respectively.

Butyrolactones from the Fermentation Products of the Endophytic Fungus Aspergillus versicolor

Two new butyrolactones, versicolactones E–F (1 and 2), along with three known butyrolactones (3–5), were isolated from the fermentation products of the endophytic fungus Aspergillus versicolor. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1–5 were evaluated. Compounds 1–5 showed modest anti-TMV activities with inhibition rates of 14.6–18.8%.

Cytotoxic Chalcones from Desmodium oxyphyllum

Three new chalcones were isolated from Desmodium oxyphyllum. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-nuclear magnetic ressonance techniques. The compounds were evaluated for their cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7). The results showed that the compounds exhibited weak cytotoxicity against some selected cell lines with IC50 values ranging from 3.6 to 8.9 μM.