Yuede Wang

Antiviral and Cytotoxic Isocoumarin Derivatives from an Endophytic Fungus Aspergillus oryzae.

Oryzaeins A-D (1-4), four new isocoumarin derivatives, along with five known ones (5-9) were isolated from solid cultures of an endophytic fungus Aspergillus oryzae. Their structures were elucidated by detailed spectroscopic analysis and by comparison with reported data of related derivatives. Among them, compounds 1 and 2 represent the first examples of isocoumarins possessing an unusual 2-oxopropyl group and a rare 3-hydroxypropyl group. Compounds 1 and 2 displayed moderate anti-tobacco mosaic virus activities with inhibition rates of 28.4% and 30.6%, respectively, at the concentration of 20 µM. The new compounds showed moderate inhibitory activities against several human tumor cell lines with IC50 values in the range of 2.8-8.8 µM. Supporting information available online at http://www.thieme-connect.de/products.

Butyrolactones from the Endophytic Fungus Aspergillus versicolor and their Anti-Tobacco Mosaic Virus Activity

New butyrolactones aspernolides C and D, along with two known butyrolactones (A and B) were isolated from the culture of the endophytic fungus Aspergillus versicolor. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D nuclear magnetic ressonance techniques, and electronic circular dichroism. The butyrolactones aspernolides C and D were tested for their anti-tobacco mosaic virus activity. The results showed that butyrolactones aspernolides C and D exhibited moderate anti-tobacco mosaic virus activity with IC50 values of 64.2 and 88.6 μM, respectively.

Anti-Tobacco Mosaic Virus Isocoumarins from the Leaves of Nicotiana tabacum

Two new isocoumarins, tabaisocoumarins D and E (1 and 2), together with two known isocoumarins (3 and 4), were isolated from the leaves of Nicotiana tabacum. The structures of 1–4 were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1–4 were also tested for their anti-tobacco mosaic virus (anti-TMV) activities. Compounds 1–4 exhibited anti-TMV activities with inhibition rates in the range of 11.2–17.5%.

Dihydroxanthenones from the Fermentation Product of the Endophytic Fungus Gliomastix murorum

Two new dihydroxanthones, muroxanthenones D and E (1 and 2), were isolated from the fermentation products of the endophytic fungus Gliomastix murorum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and they exhibited activity with inhibition rates of 16.4 and 15.3%, respectively.

Chalcones from Desmodium podocarpum and Their Anti-Tobacco Mosaic Virus Activity

Two new chalcones, podocarchalcones A and B (1 and 2), together with five known chalcones (3–7), were isolated from the whole plants of Desmodium podocarpum. All of their structures were determined by spectroscopic methods including 1D and 2D NMR. Compounds 1–7 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activity, and they exhibited activity with inhibition rates in the range of 15.2–22.4%, respectively.

Butyrolactones from the Fermentation Products of the Endophytic Fungus Aspergillus versicolor

Two new butyrolactones, versicolactones E–F (1 and 2), along with three known butyrolactones (3–5), were isolated from the fermentation products of the endophytic fungus Aspergillus versicolor. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1–5 were evaluated. Compounds 1–5 showed modest anti-TMV activities with inhibition rates of 14.6–18.8%.