Yan-Qing Ye

Anti-Tobacco Mosaic Virus Chromones from the Twigs of Cassia fistula

Two new chromones, fistulachromones A and B (1 and 2), together with three known chromones (3–5), were isolated from the twigs of Cassia fistula. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. Compounds 1 and 2 showed high anti-TMV activities with inhibition rates of 27.5 and 30.8%, respectively. These rates are close to that of positive control.

Anthraquinones from the Barks of Cassia alata and their Anti-Tobacco Mosaic Virus Activity

Two new anthraquinones, alataquinones A and B (1 and 2), together with two known anthraquinones (3 and 4), were isolated from the barks of Cassia alata. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–4 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1–4 exhibited moderate anti-TMV activity with inhibition rates in the range of 22.8–26.4%.

Two New Isoquinoline Alkaloids from the Barks of Cassia fistula and Their Anti-Tobacco Mosaic Virus Activity

Two new isoquinoline alkaloids, fistulaquinolines A and B (1 and 2), were isolated from the barks of Cassia fistula. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that the two compounds showed weak anti-TMV activity with inhibition rates of 18.9 and 22.6%.

New Biphenyls from Garcinia multiflora

Three new biphenyls were isolated from Garcinia multiflora. The structures of these biphenyls were elucidated by spectroscopic methods, and their rotavirus activity was evaluated.

Chalcones from Desmodium podocarpum and Their Anti-Tobacco Mosaic Virus Activity

Two new chalcones, podocarchalcones A and B (1 and 2), together with five known chalcones (3–7), were isolated from the whole plants of Desmodium podocarpum. All of their structures were determined by spectroscopic methods including 1D and 2D NMR. Compounds 1–7 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activity, and they exhibited activity with inhibition rates in the range of 15.2–22.4%, respectively.

Cytotoxic Chalcones from Desmodium oxyphyllum

Three new chalcones were isolated from Desmodium oxyphyllum. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-nuclear magnetic ressonance techniques. The compounds were evaluated for their cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7). The results showed that the compounds exhibited weak cytotoxicity against some selected cell lines with IC50 values ranging from 3.6 to 8.9 μM.