Christian Bäumer

Experimental feasibility of multi-energy photon-counting K-edge imaging in pre-clinical computed tomography

Theoretical considerations predicted the feasibility of K-edge x-ray computed tomography (CT) imaging using energy discriminating detectors with more than two energy bins. This technique enables material-specific imaging in CT, which in combination with high-Z element based contrast agents, opens up possibilities for new medical applications. In this paper, we present a CT system with energy detection capabilities, which was used to demonstrate the feasibility of quantitative K-edge CT imaging experimentally. A phantom was imaged containing PMMA, calcium-hydroxyapatite, water and two contrast agents based on iodine and gadolinium, respectively. Separate images of the attenuation by photoelectric absorption and Compton scattering were reconstructed from energy-resolved projection data using maximum-likelihood basis-component decomposition. The data analysis further enabled the display of images of the individual contrast agents and their concentrations, separated from the anatomical background. Measured concentrations of iodine and gadolinium were in good agreement with the actual concentrations. Prior to the tomographic measurements, the detector response functions for monochromatic illumination using synchrotron radiation were determined in the energy range 25 keV-60 keV. These data were used to calibrate the detector and derive a phenomenological model for the detector response and the energy bin sensitivities.

Status of Direct Conversion Detectors for Medical Imaging With X-Rays

Imaging detectors for medical X-ray and computed tomography (CT) applications have undergone many improvements and technology changes over time. But most (dynamic) detectors sold in this field still rely on indirect conversion, using scintillators and photodiodes to convert the X-ray quanta ultimately into electrical signals. Direct conversion detectors promise very high spatial resolution and high signal-to-noise ratios. Some direct conversion materials may allow for counting or even energy resolving detection of the X-ray quanta. Based on this, for example spectrally resolving CT systems are becoming an interesting option for the next decade. This contribution highlights the requirements of advanced medical X-ray and CT imaging and reviews examples of status and progress in the field. The emphasis is on the direct conversion sensors for pixelated detectors, but considerations on read-out concepts and on associated challenges such as interconnects will also be presented. Finally, the most burning issues, such as count rate limitations and polarization effects, will be discussed from an application point of view.

Spectral analysis of scattered radiation in CT

In the framework of Spectral Computed Tomography (Spectral CT), scattered X-ray radiation is examined for its spectral composition and spatial distribution by means of Monte Carlo simulations. A reliable material (e.g. bone / contrast agent) separation and quantification requires a precise knowledge of the transmitted X-ray spectrum especially for low energy photons. Unfortunately, for lower energies the primary intensity is increasingly covered by scattered radiation. The detected scattered radiation can be classified into two main categories with respect to their scattering history. The first category contains purely Rayleigh or one-time Compton scattered photons which typically have small scattering angles and an energy spectrum similar to that of the transmitted primary radiation. The second category comprises multiple Compton scattered photons with a spectral composition which is typically softer than that of the transmitted primary photons. In regions of strong beam attenuation (i.e. in the X-ray shadow of a scanned object), the scattered radiation is mainly composed of multiple Compton scattered photons. As a consequence, the spectrally resolved scatter-to-primary ratios strongly increase at low energies. High-quality anti-scatter grids can be used to reduce especially the detection of multiple Compton-scattered photons. A quantitative evaluation of measured photon energies below a certain limit between 30 keV and 50 keV (depending on the phantom geometry and the applied anti-scatter grid) is challenging, since primary photons are superposed by a significantly higher amount of scattered photons.

Towards direct conversion detectors for medical imaging with X-rays

Imaging detectors for medical X-ray and Computed Tomography (CT) applications have undergone many improvements and technology changes over time. But most (dynamic) detectors sold in this field still rely on indirect conversion, using scintillators and photodiodes to convert the X-ray quanta ultimately into electrical signals. Direct conversion detectors promise very high spatial resolution and high signal-to-noise ratios. Some direct conversion materials may allow for counting or even energy resolving detection of the X-ray quanta. Based on this, for example spectrally resolving CT systems are becoming an interesting option for the next decade. This contribution highlights the requirements of advanced medical X-ray and CT imaging and shows examples of status and progress in the field. The emphasis is on the direct conversion sensors for pixelated detectors, but considerations on read-out concepts and on associated challenges such as interconnects will also be presented. Finally, the most burning issues, such as count rate limitations and polarization effects, will be discussed from an application point of view.

Testing an Energy-Dispersive Counting-Mode Detector With Hard X-Rays From a Synchrotron Source

A counting-mode line detector has been evaluated at a synchrotron radiation source in order to assess its performance for imaging applications. The x-ray detector is based on 3 mm thick CdZnTe arrays with 1 mm pixel pitch and multi-threshold counting electronics. Data readout has been performed in threshold scan mode to provide maximum energy dispersion. The acquired energy spectra are interpreted regarding the characteristics of a periodic source and pulse pile-up in the detector. In particular, energy response and rate behavior of single-photon and double-photon events are investigated. Count rate dynamics are studied up to incident rates of . A further subject of the investigation is the variance of the observed counting rate. Linearity in the energy domain is tested between 40 keV and 140 keV.

Correction to "Status of Direct Conversion Detectors for Medical Imaging With X-Rays" [Aug 09 1800-1809]

In the above titled paper (ibid., vol. 56, no. 4, pp. 1800-1809, Aug. 09), an error appeared in Table III. A corrected version of Table III is presented here.