Christoph Schwemler

New hetero-oligomeric peptide nucleic acids with improved binding properties to complementary DNA

Abstract Hetero-oligomeric PNAs consisting of new monomeric building blocks and various amounts of N-(2-aminoethyl) glycine have been synthesized by solid-phase chemistry. Some of these new compounds show stronger binding to complementary DNA than the original PNAs, and are consequently very interesting candidates as antisense compounds for applications in therapy and in diagnostics.

Synthesis of new building blocks for peptide nucleic acids containing monomers with variations in the backbone

Abstract New PNA monomers containing aminoprolines or pyrrolidines as backbones have been synthesized. Oligomerisation was carried out on a solid support. Resistance to enzymatic degradation was tested.