David Mack Floyd
Harvard University
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Featured researches published by David Mack Floyd.
Enfermedades Infecciosas Y Microbiologia Clinica | 1985
Richard B. Sykes; William Lawrence Parker; Christopher Michael Cimarusti; William Henry Koster; William Allen Slusarchyk; Alan William Fritz; David Mack Floyd
Beta-lactam drugs, whose mechanism of action is inhibition of the last stage of bacterial cell wall synthesis, are the largest family of antimicrobial agents and the most widely used in current clinical practice. These drugs have a slow, time-dependent bactericidal action, generally good distribution in the body, and low toxicity. Modifications of the original molecule have led to new compounds with a greater antimicrobial spectrum and activity; nonetheless, the use and efficacy of beta-lactams is limited in some clinical settings, owing to the increasing emergence of antimicrobial resistance. Despite this problem, penicillin remains the treatment of choice in a large number of infections, cephalosporins have a wide range of indications, carbapenems are used in nosocomially-acquired infection and infection caused by multiresistant microorganisms, and beta-lactam inhibitors restore the spectrum of activity of their companion penicillins (aminopenicillins, ureidopenicillins) when resistance is caused by beta lactamase production.
Journal of the American Chemical Society | 1981
Bruce H. Lipshutz; Robert S. Wilhelm; David Mack Floyd
Journal of Organic Chemistry | 1978
E. J. Corey; David Mack Floyd; Bruce H. Lipshutz
ChemInform | 2002
E. J. Corey; Leland O. Weigel; David Mack Floyd; Mark G. Bock
Journal of Organic Chemistry | 1982
David Mack Floyd; Alan William Fritz; Christopher M. Cimarusti
Tetrahedron Letters | 1978
E. J. Corey; Mark G. Bock; Alan P. Kozikowski; A. V. Rama Rao; David Mack Floyd; Bruce Lipshutz
Journal of Organic Chemistry | 1972
E. J. Corey; Shiro. Terashima; Peter W. Ramwell; Reginald. Jessup; Ned M. Weinshenker; David Mack Floyd; Guy A. Crosby
Journal of Organic Chemistry | 1982
Christopher M. Cimarusti; Harold E. Applegate; H. W. Chang; David Mack Floyd; W. H. Koster; W. A. Slusarchyk; M. G. Young
The Journal of Antibiotics | 1982
William L. Parker; William Henry Koster; Christopher M. Cimarusti; David Mack Floyd; Wen-Chih Liu; Marlene L. Rathnum
ChemInform | 1983
David Mack Floyd; A. W. Fritz; J. Pluscec; E. R. Weaver; Christopher M. Cimarusti