Ekaterina M. Cheprakova

Synthesis of 5-(het)aryl- and 4,5-di(het)aryl-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via SNH and cross-coupling reactions

It has been shown that various combinations of nucleophilic aromatic substitution of hydrogen (SNH), SNipso and the microwave-assisted Suzuki cross-coupling reactions are a versatile method for the synthesis of 5-(het)aryl-2-(thio)morpholinopyrimidine and 4,5-di(het)aryl-2-(thio)morpholinopyrimidine derivatives. All synthesized pyrimidines were found to be active in micromolar concentrations in vitro against Mycobacterium tuberculosis H37Rv.

2-amino-5-aryl- and 2-amino-5-hetaryl-3-cyano-6-(2-thienyl)pyridines as Organic Dyes for Dye-Sensitized Solar Cells: Synthesis, Quantum-Chemical Calculations, Spectral and Electrochemical Properties

Novel organic dyes containing pyridine ring as the anchoring group with carbazole or triphenylamine substituents were synthesized from available 4-(2-thienyl)pyrimidine using the Kost–Sagitullin rearrangement and Suzuki cross coupling assisted by microwave irradiation. The photophysical (absorption and photoluminescence spectra) and electrochemical properties of these compounds were investigated. The data from quantum calculations show that all of the dyes are potentially good photosensitizers for dye-sensitized solar cells.

Synthesis of 6-thienyl-substituted 2-amino-3-cyanopyridines

An efficient method for the synthesis of 6-thienyl-substituted 2-amino-3-cyanopyridines by the ring transformation in the corresponding pyrimidines was developed. Further modification of the pyridines obtained under conditions of a room temperature aerobic Suzuki reaction in the presence of trans-bis(dicyclohexylamine)palladium(II) acetate as a catalyst was studied