Elisabeth Steinmann
University of Kiel
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Featured researches published by Elisabeth Steinmann.
Brain Topography | 2012
Michael Siniatchkin; Nora Glatthaar; Gabriele Gerber-von Müller; Alexander Prehn-Kristensen; Stephan Wolff; Silja Knöchel; Elisabeth Steinmann; Anna Sotnikova; Ulrich Stephani; Franz Petermann; Wolf-Dieter Gerber
Response cost and token approach (RCT) within the scope of a summer camp training is an effective treatment program for attention deficit hyperactivity disorder (ADHD). It is likely that intensive RCT training influences networks responsible for ADHD symptoms. Functional magnetic resonance imaging (fMRI) was carried out in 12 children with ADHD before and after the RCT program and in 12 healthy control children twice. For fMRI, a Go/No-go paradigm was used to investigate the influence of RCT training on attention and impulsivity. The No-go condition revealed only weak activation in the dorsal part of the anterior cingulate cortex (ACC), parietal and dorsolateral prefrontal cortex (DLPFC) before the training in children with ADHD compared to healthy children. However, this activation in these brain regions was significantly more pronounced after the training. This increase in hemodynamic response cannot be attributed merely to repetition of the measurement since the effect was not observed in healthy children. The increase in hemodynamic response in the ACC and right DLPFC was significantly associated with a reduction in response time variability and clinical symptoms in ADHD patients. After the RCT training, the children with ADHD demonstrated more pronounced activation of cortical structures which are typically related to response monitoring and self-control. It seems likely that children with ADHD learned more cognitive control in a continuous performance task as was revealed by both neuropsychological outcome and fMRI.
Epilepsia | 2013
Friederike Moeller; Jan Moehring; Imke Ick; Elisabeth Steinmann; Stephan Wolff; Olav Jansen; Rainer Boor; Ulrich Stephani; Michael Siniatchkin
Atypical benign partial epilepsy (ABPE) is a subgroup among the idiopathic focal epilepsies of childhood. Aim of this study was to investigate neuronal networks underlying ABPE and compare the results with previous electroencephalography (EEG)–functional magnetic resonance imaging (fMRI) studies of related epilepsy syndromes. Ten patients with ABPE underwent simultaneous EEG‐fMRI recording. In all 10 patients several types of interictal epileptiform discharges (IEDs) were recorded. Individual IED‐associated blood oxygen level–dependent (BOLD) signal changes were analyzed in a single subject analysis for each IED type (33 studies). A group analysis was also performed to determine common BOLD signal changes across the patients. IED‐associated BOLD signal changes were found in 31 studies. Focal BOLD signal changes concordant with the spike field (21 studies) and distant cortical and subcortical BOLD signal changes (31 studies) were detected. The group analysis revealed a thalamic activation. This study demonstrated that ABPE is characterized by patterns similar to studies in rolandic epilepsy (focal BOLD signal changes in the spike field) as well as patterns observed in continuous spikes and waves during slow sleep (CSWS) (distant BOLD signal changes in cortical and subcortical structures), thereby underscoring that idiopathic focal epilepsies of childhood form a spectrum of overlapping syndromes.
Neuropsychologia | 2014
Elisabeth Steinmann; Antonia Schmalor; Alexander Prehn-Kristensen; Stephan Wolff; Andreas Galka; Jan Möhring; Wolf-Dieter Gerber; Franz Petermann; Ulrich Stephani; Michael Siniatchkin
OBJECTIVES One of the important prerequisites for successful social interaction is the willingness of each individual to cooperate socially. Using the ultimatum game, several studies have demonstrated that the process of decision-making to cooperate or to defeat in interaction with a partner is associated with activation of the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), anterior insula (AI), and inferior frontal cortex (IFC). This study investigates developmental changes in this neuronal network. METHODS 15 healthy children (8-12 years), 15 adolescents (13-18 years) and 15 young adults (19-28 years) were investigated using the ultimatum game. Neuronal networks representing decision-making based on strategic thinking were characterized using functional MRI. RESULTS In all age groups, the process of decision-making in reaction to unfair offers was associated with hemodynamic changes in similar regions. Compared with children, however, healthy adults and adolescents revealed greater activation in the IFC and the fusiform gyrus, as well as the nucleus accumbens. In contrast, healthy children displayed more activation in the AI, the dorsal part of the ACC, and the DLPFC. There were no differences in brain activations between adults and adolescents. CONCLUSION The neuronal mechanisms underlying strategic social decision making are already developed by the age of eight. Decision-making based on strategic thinking is associated with age-dependent involvement of different brain regions. Neuronal networks underlying theory of mind and reward anticipation are more activated in adults and adolescents with regard to the increasing perspective taking with age. In relation to emotional reactivity and respective compensatory coping in younger ages, children have higher activations in a neuronal network associated with emotional processing and executive control.
European Journal of Paediatric Neurology | 2014
Natia Japaridze; Esther Menzel; Gisela von Ondarza; Elisabeth Steinmann; Ulrich Stephani
BACKGROUND Atypical benign partial epilepsy/pseudo-Lennox syndrome (ABPE/PLS) and continues spike and wave during sleep (CSWS) belong to a spectrum of idiopathic focal epilepsy syndromes ranging from benign Rolandic epilepsy to more severe seizure disorders, which are commonly characterized by the association of various epileptic seizure types, aggravation of spike-wave discharges during slow sleep, and cognitive and/or behavioral disturbances. The Aim of our study was to evaluate the risk factors that influence cognitive outcome in patients with ABPE/PLS and CSWS in a retrospective analysis. METHODS Thirty patients fulfilled the diagnostic criteria for ABPE/PLS and 12 for CSWS and were chosen for the descriptive analysis. Cognitive achievement was evaluated according to psychological tests and school performances. RESULTS Severe global and specific cognitive disturbances occurred almost regularly in cases of ABPE. Already at the time of epilepsy presentation the level of cognitive performance was lower than that of the normal population. At the time of disease presentation only 56% of the children had IQ within the standard range (≥85). We observed that the level of cognitive developmental delay did not change significantly during the disease process. We were not able to observe any statistically significant connection between the development of EEG abnormalities and cognitive development. The conclusion can be drawn that many patients exhibit cognitive impairment at disease presentation which is not affected significantly during the treatment process. Judging from the observed data, we assume that EEG abnormalities, duration of active epilepsy, and antiepileptic medication have less influence on the cognitive development than was previously assumed.
European Journal of Paediatric Neurology | 2018
Michael Siniatchkin; Jan Moehring; Bianca Kroeher; Andreas Galka; Gisela von Ondarza; Friederike Moeller; Stephan Wolff; Enzo Tagliazucchi; Elisabeth Steinmann; Rainer Boor; Ulrich Stephani
OBJECTIVE Multifocal epileptic activity is an unfavourable feature of a number of epileptic syndromes (Lennox-Gastaut syndrome, West syndrome, severe focal epilepsies) which suggests an overall vulnerability of the brain to pathological synchronization. However, the mechanisms of multifocal activity are insufficiently understood. This explorative study investigates whether pathological connectivity within brain areas of the default mode network as well as thalamus, brainstem and retrosplenial cortex may predispose individuals to multifocal epileptic activity. METHODS 33 children suffering from multifocal and monofocal (control group) epilepsies were investigated using EEG-fMRI recordings during sleep. The blood oxygenated level dependent (BOLD) signal of 15 regions of interest was extracted and temporally correlated (resting-state functional connectivity). RESULTS Patients with monofocal epilepsies were characterized by strong correlations between the corresponding interhemispheric homotopic regions. This pattern of correlations with pronounced short-distance and weak long-distance functional connectivity resembles the connectivity pattern described for healthy children. Patients with multifocal epileptic activity, however, demonstrated significantly stronger correlations between a large number of regions of the default mode network as well as thalamus and brainstem, with a significant increase in long-distance connectivity compared to children with monofocal epileptic activity. In the group of patients with multifocal epilepsies there were no differences in functional connectivity between patients with or without Lennox-Gastaut syndrome. CONCLUSION This explorative study shows that multifocal activity is associated with generally increased long-distance functional connectivity in the brain. It can be suggested that this pronounced connectivity may represent either a risk to pathological over-synchronization or a consequence of the multifocal epileptic activity.
Biological Psychology | 2018
Jens T. Kowalski; Franziska Falkenhagen; Yvonne Radtke; Uwe Niederberger; Franz Petermann; Stephanie Darabaneanu; Elisabeth Steinmann; Wolf-Dieter Gerber; Michael Siniatchkin
It is still unclear why some individuals completely recover after an acute trauma and others develop a long-lasting post-traumatic stress disorder (PTSD). This study investigates whether the contingent negative variation (CNV) - a slow negative event-related potential - may be associated with the occurrence of PTSD after acute trauma. CNV (auditory 2-stimulus reaction time paradigm) was recorded within one month as well as 6 months after an acute trauma (dangerous or grave physical injuries, witnessing of attempted suicide or murder, robbery, extortion, accidents, heavy illness, death or loss of an important person, hostage-taking) in 39 otherwise healthy adults and compared with CNV recordings in 38 healthy control subjects without potentially traumatizing experience in their history. According to their subsequent clinical course, these subjects were divided into two groups: participants who recovered completely 1 month after the trauma (PTSD- group, n = 31), and those who began to experience PTSD (PTSD+ group, n = 8). Patients from both trauma groups were characterized by a significantly longer reaction time immediately after the trauma. The PTSD+ group demonstrated lower amplitudes of the late CNV component immediately and six months after the trauma compared with the PTSD- and the control group. Whether the lower CNV amplitudes in patients who develop PTSD after the acute trauma, which is already present in the first days after the trauma, may be related to a higher risk for development of PTSD in these subjects, this has to be clarified in further prospective studies.
Kindheit Und Entwicklung | 2012
Sören Schmidt; Stephanie Ender; Jan Schultheiß; Gabriele Gerber-von Müller; Wolf-Dieter Gerber; Elisabeth Steinmann; Ulrike Petermann; Franz Petermann
Kindheit Und Entwicklung | 2013
Christin Haselbeck; Alexandra Kulle; Uwe Niederberger; Til Ole Bergmann; Elisabeth Steinmann; Paul-Martin Holterhus; Franz Petermann; Wolf-Dieter Gerber
Zeitschrift Fur Neuropsychologie | 2012
Anna Sotnikova; Elisabeth Steinmann; Vanessa Wendisch; Gabriele Gerber-von Müller; Ulrich Stephani; Franz Petermann; Wolf-Dieter Gerber; Michael Siniatchkin
Zeitschrift Fur Neuropsychologie | 2012
Elisabeth Steinmann; Michael Siniatchkin; Franz Petermann; Wolf-Dieter Gerber