Francesca Everest
Northumbria University
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Featured researches published by Francesca Everest.
Frontiers in Microbiology | 2015
Mohammad Tariq; Francesca Everest; Lauren A. Cowley; Anthony De Soyza; Giles Holt; Simon Bridge; Audrey Perry; John D. Perry; Stephen Bourke; Stephen P. Cummings; Clare Lanyon; Jeremy J. Barr; Darren Smith
Pseudomonas aeruginosa (Pa), normally a soil commensal, is an important opportunistic pathogen in Cystic Fibrosis (CF) and non-Cystic Fibrosis Bronchiectasis (nCFBR). Persistent infection correlates with accelerated decline in lung function and early mortality. The horizontal transfer of DNA by temperate bacteriophages can add gene function and selective advantages to their bacterial host within the constrained environment of the lower lung. In this study, we chemically induce temperate bacteriophages from clonal cultures of Pa and identify their mixed viral communities employing metagenomic approaches. We compared 92 temperate phage metagenomes stratified from these clinical backgrounds (47 CF and 45 nCFBR Pa isolates) using MG-RAST and GeneWise2. KEGG analysis shows the complexity of temperate phage accessory gene carriage increases with duration and severity of the disease. Furthermore, we identify the presence of Ig-like motifs within phage structural genes linked to bacterial adhesion and carbohydrate binding including Big_2, He_Pig, and Fn3. This study provides the first clinical support to the proposed bacteriophage adherence to mucus (BAM) model and the evolution of phages interacting at these mucosal surfaces over time.
publisher | None
author
Archive | 2016
Francesca Everest; Giles Holt; Carl Robinson; Andrew S. Waller; Darren Smith
Archive | 2016
Francesca Everest; Mohammad Tariq; Giles Holt; John Lodge; Audrey Perry; John Perry; Stephen C Bourke; Clare Lanyon; Stephen P. Cummings; Anthony de Soyza; Darren Smith
Archive | 2016
Mohammad Tariq; Francesca Everest; Lauren A. Cowley; Giles Holt; Anthony de Soyza; Audrey Perry; John Perry; Darren Smith
Archive | 2016
Francesca Everest; Mohammad Tariq; Giles Holt; John Lodge; Audrey Perry; John Perry; Stephen C Bourke; Clare Lanyon; Stephen P. Cummings; Anthony de Soyza; Darren Smith
Archive | 2015
Mohammad Tariq; Giles Holt; Francesca Everest; Lauren A. Cowley; John Lodge; Audrey Perry; John Perry; Stephen C Bourke; Clare Lanyon; Stephen P. Cummings; Jeremy J. Barr; Anthony de Soyza; Darren Smith
Archive | 2014
Francesca Everest; Mohammad Tariq; Anthony de Soyza; Audrey Perry; John Perry; Stephen P. Cummings; Clare Lanyon; Darren Smith
Archive | 2014
Francesca Everest; Mohammad Tariq; Rhys Wilson; Anthony de Soyza; Audrey Perry; John Perry; Stephen C Bourke; Stephen P. Cummings; Clare Lanyon; Darren Smith
Archive | 2014
Mohammad Tariq; Giles Holt; Francesca Everest; Anthony de Soyza; Audrey Perry; John Perry; Stephen P. Cummings; Clare Lanyon; Darren Smith