Hans-Christian Hanke

A digital CMOS DNA chip

A fully electronic medium density DNA micro array is presented using a CMOS process extended by gold electrodes. The chip provides 128 sensor sites, in-sensor site current-mode A/D conversion, peripheral circuitry including bandgap and current references, D/A-converters to provide electrode bias voltages, calibration circuitry, and a 6 pin interface for power supply and serial digital data transfer.

CMOS-Based Biosensor Arrays

CMOS-based sensor array chips provide new and attractive features as compared to todays standard tools for medical, diagnostic, and biotechnical applications. Examples for molecule- and cell-based approaches and related circuit design issues are discussed.

A CMOS Medium Density DNA Microarray with Electronic Readout

A CMOS chip-based approach is reviewed for fully electronic DNA detection. The electrochemical sensor principle used, CMOS integration of the required transducer materials, chip architecture and circuit design issues are discussed, respectively. Electrochemical and biological results obtained on the basis of medium density microarray sensor CMOS chips with 16 × 8 sensor sites prove proper operation.