Hironao Sakaki

Energy Increase in Multi-MeV Ion Acceleration in the Interaction of a Short Pulse Laser with a Cluster-Gas Target

We demonstrate generation of 10-20 MeV/u ions with a compact 4 TW laser using a gas target mixed with submicron clusters, corresponding to tenfold increase in the ion energies compared to previous experiments with solid targets. It is inferred that the high energy ions are generated due to formation of a strong dipole vortex structure. The demonstrated method has a potential to construct compact and high repetition rate ion sources for hadron therapy and other applications.

Application of laser-accelerated protons to the demonstration of DNA double-strand breaks in human cancer cells

We report the demonstrated irradiation effect of laser-accelerated protons on human cancer cells. In vitro (living) A549 cells are irradiated with quasimonoenergetic proton bunches of 0.8–2.4 MeV with a single bunch duration of 15 ns. Irradiation with the proton dose of 20 Gy results in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks generated in the cancer cells. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. Unique high-current and short-bunch features make laser-driven proton bunches an excitation source for time-resolved determination of radical yields.

Proton acceleration to 40 MeV using a high intensity, high contrast optical parametric chirped-pulse amplification/Ti:sapphire hybrid laser system.

Using a high-contrast (10(10):1) and high-intensity (10(21) W/cm(2)) laser pulse with the duration of 40 fs from an optical parametric chirped-pulse amplification/Ti:sapphire laser, a 40 MeV proton bunch is obtained, which is a record for laser pulse with energy less than 10 J. The efficiency for generation of protons with kinetic energy above 15 MeV is 0.1%.

Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline

Human cancer cells are irradiated by laser-driven quasimonoenergetic protons. Laser pulse intensities at the 5×1019 W/cm2 level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton irradiation at dose levels of up to 8 Gy, for which the single bunch dose rate is 1×107 Gy/s and the effective dose rate is 0.2 Gy/s for 1 Hz repetition of irradiation. Relative biological effectiveness at the 10% survival fraction is measured to be 1.20±0.11 using protons with a linear energy transfer of 17.1 keV/μm.

Focusing and spectral enhancement of a repetition-rated, laser-driven, divergent multi-MeV proton beam using permanent quadrupole magnets

A pair of conventional permanent magnet quadrupoles is used to focus a 2.4 MeV laser-driven proton beam at a 1 Hz repetition rate. The magnetic field strengths are 55 and 60 T/m for the first and second quadrupoles, respectively. The proton beam is focused to a spot with a size of less than ∼3×8 mm2 at a distance of 650 mm from the source. This result is in good agreement with the Monte Carlo particle trajectory simulation.

Acceleration of highly charged GeV Fe ions from a low-Z substrate by intense femtosecond laser

Almost fully stripped Fe ions accelerated up to 0.9 GeV are demonstrated with a 200 TW femtosecond high-intensity laser irradiating a micron-thick Al foil with Fe impurity on the surface. An energetic low-emittance high-density beam of heavy ions with a large charge-to-mass ratio can be obtained, which is useful for many applications, such as a compact radio isotope source in combination with conventional technology.

High-Contrast, High-Intensity Petawatt-Class Laser and Applications

A high-contrast high-intensity petawatt-class Ti:sapphire chirped-pulse amplification laser has been developed for research on high field science. A saturable absorber and a low-gain optical parametric chirped-pulse amplification preamplifier in the front-end have improved the temporal contrast in the system to ∼

Nonlinear increase of X-ray intensities from thin foils irradiated with a 200 TW femtosecond laser

2 \times 10^{12}

Submicron ionography of nanostructures using a femtosecond-laser-driven-cluster-based source

on the subnanosecond time scale at the ∼70 TW power level. In addition to the high-contrast broadband high-energy output from the final amplifier has been achieved with a flat-top spatial profile with a filling factor of ∼70%. This is the result of pump beam spatial profile homogenization with diffractive optical elements. The system produces the uncompressed output pulse energy of 29 J, indicating the capability for reaching a peak power of ∼600 TW. We discuss in detail the design, performance, and characterization of the laser including output power, pulse duration, and spatiotemporal beam quality. We also describe the on-going upgrade of the laser system and some applications for the laser in relativistic dominated laser–matter interactions.

Characterization of submicron-sized CO2 clusters formed with a supersonic expansion of a mixed-gas using a three-staged nozzle

We report, for the first time, that the energy of femtosecond optical laser pulses, E, with relativistic intensities I > 1021  W/cm2 is efficiently converted to X-ray radiation, which is emitted by “hot” electron component in collision-less processes and heats the solid density plasma periphery. As shown by direct high-resolution spectroscopic measurements X-ray radiation from plasma periphery exhibits unusual non-linear growth ~E4–5 of its power. The non-linear power growth occurs far earlier than the known regime when the radiation reaction dominates particle motion (RDR). Nevertheless, the radiation is shown to dominate the kinetics of the plasma periphery, changing in this regime (now labeled RDKR) the physical picture of the laser plasma interaction. Although in the experiments reported here we demonstrated by observation of KK hollow ions that X-ray intensities in the keV range exceeds ~1017  W/cm2, there is no theoretical limit of the radiation power. Therefore, such powerful X-ray sources can produce and probe exotic material states with high densities and multiple inner-shell electron excitations even for higher Z elements. Femtosecond laser-produced plasmas may thus provide unique ultra-bright X-ray sources, for future studies of matter in extreme conditions, material science studies, and radiography of biological systems.