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Dive into the research topics where John T. Santini is active.

Publication


Featured researches published by John T. Santini.


Nature Biotechnology | 2006

Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device

James H. Prescott; Sara A. Lipka; Samuel P. Baldwin; Norman F. Sheppard; John M. Maloney; Jonathan R. Coppeta; Barry Yomtov; Mark A. Staples; John T. Santini

Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.


Archive | 2002

Flexible microchip devices for ophthalmic and other applications

John T. Santini; Michael J. Cima; Robert S. Langer; Dennis Ausiello; Norman F. Sheppard; Stephen J. Herman


Archive | 2002

Methods for hermetically sealing microchip reservoir devices

Scott A. Uhland; Benjamin F. Polito; Stephen J. Herman; John T. Santini; John M. Maloney


Journal of Controlled Release | 2005

Electrothermally activated microchips for implantable drug delivery and biosensing.

John M. Maloney; Scott A. Uhland; Benjamin F. Polito; Norman F. Sheppard; Christina M. Pelta; John T. Santini


Archive | 2007

Multi-reservoir pump device for dialysis, biosensing, or delivery of substances

John T. Santini; Michael F. Cima; Jonathan R. Coppeta; James H. Prescott; Zouhair Sbiaa; Mark A. Staples


Archive | 2005

Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant

Stephen J. Herman; Timothy Kreiger; John T. Santini; James H. Prescott; Mark A. Staples; Sara A. Lipka


Archive | 2007

Device for the controlled exposure of reservoir-based sensors

John T. Santini; Norman F. Sheppard; Chung Chang Young; Robert S. Langer


Archive | 2006

Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents

Jonathan R. Coppeta; Scott A. Uhland; Benjamin F. Polito; Norman F. Sheppard; Christina M. Feakes; Douglas B. Snell; John T. Santini


Archive | 2007

Method of actuating implanted medical device

John T. Santini; Michael J. Cima; Robert S. Langer; Dennis Ausiello; Norman F. Sheppard


Archive | 2001

Microfabricated devices and methods for storage and selective exposure of chemicals

Robert S. Langer; John T. Santini; Norman F. Sheppard; Chung Chang Young

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