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Dive into the research topics where Lars Holzer is active.

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Featured researches published by Lars Holzer.


Resuscitation | 2011

Disposable laryngeal tube suction: Standard insertion technique versus two modified insertion techniques for patients with a simulated difficult airway

Richard Schalk; Stephan Engel; Dirk Meininger; Kai Zacharowski; Lars Holzer; Bertram Scheller; Christian Byhahn

OBJECTIVE The disposable laryngeal tube suction (LTS-D) is a supraglottic airway device that can be used as an alternative to tracheal tube to provide ventilation. We tested the hypothesis that, with a frontal jaw thrust insertion technique (FIT/JT), the rate of correct placement attempts in patients with a simulated difficult airway by means of a rigid cervical immobilization collar could be significantly increased compared to the standard insertion technique (SIT) recommended by the manufacturer. METHODS 70 adult patients undergoing trauma surgery under general anaesthesia had an LTS-D inserted, randomly assigned to the SIT or FIT/JT. In the FIT/JT, the operator was standing in front of the patients head, and forced chin lift to create sufficient retropharyngeal space was performed. The rate of successful tube placements within 180s and with a maximum of two attempts was the main outcome variable. To distinguish between the effects of the frontal approach and the jaw thrust manoeuvre, a third group was studied after completion of the SIT and FIT/JT groups. The standard insertion technique, but with a jaw thrust manoeuvre (SIT/JT), was employed in another 35 consecutive patients. RESULTS Overall placement success was 49% (SIT, 17/35 patients, P<0.001), 91% (SIT/JT, 32/35 patients) and 100% (FIT/JT). The time required for successful insertion was shortest in the FIT/JT group (23±6s), and significantly longer in the SIT/JT (42±29s, P<0.001) and SIT groups (51±29s, P<0.0001). CONCLUSION In anaesthetised patients with a simulated difficult airway created with a rigid cervical collar, the overall LTS-D placement success was significantly higher when a jaw thrust manoeuvre was performed, regardless of the particular technique used to introduce the LTS-D. Therefore, an intense jaw thrust manoeuvre should be performed whenever an LTS-D is being inserted.


Anaesthesist | 2010

[Direct laryngoscopy or C-MAC video laryngoscopy? Routine tracheal intubation in patients undergoing ENT surgery].

Dirk Meininger; U. Strouhal; Christian Weber; D. Fogl; Lars Holzer; Kai Zacharowski; Christian Byhahn

BACKGROUND Previous studies have shown that video laryngoscopy enhances laryngeal view in patients with apparently normal and difficult airways. The utility of the novel, portable, battery-powered C-MAC video laryngoscope is as yet unproven. It was hypothesized that in routine patients undergoing ENT surgery, the rate of glottic views considered unsatisfactory, i.e. Cormack and Lehane grades IIb, III, and IV, could be significantly reduced with the C-MAC video laryngoscope compared to direct laryngoscopy. METHODS Following ethical approval and sample size estimates 108 consecutive patients undergoing ENT surgery under general anesthesia were studied. First, direct laryngoscopy was performed with the naked eye. The best view obtained was graded by the first anesthesiologist without looking at the video monitor. A second anesthesiologist blinded to the laryngeal view obtained under direct laryngoscopy graded the laryngeal view on the video monitor. Endotracheal intubation using Ring-Adair-Elwyn (RAE) tracheal tubes was then attempted under video-aided visualization. The tubes were not reinforced with a stylet. The C-MAC video laryngoscopy system (Karl Storz, Tuttlingen, Germany) is a novel device that can be used with Macintosh laryngoscope blades in different sizes. A camera and light source are located recessed from the tip of the blade. The camera unit sits in a handle attached to the laryngoscope blade and is connected by a wire to a TFT video monitor. It allows for both direct and indirect laryngoscopy and the low profile of the original British Macintosh blades may prove advantageous in patients with limited mouth opening. RESULTS A total of 108 patients were enrolled in the study but for various reasons only 94 completed the study (post hoc power 97%). In 89 patients a size 3 Macintosh laryngoscope was used while a size 4 blade was used in the remaining 5 patients. With direct laryngoscopy the glottic view was considered unsatisfactory in 40 patients (42%), but this was the case in only 15 patients (16%) when video laryngoscopy was used (p<0.0001). Endotracheal tube placement was successful in all but one patient where the Bonfils intubation fiberscope needed to be employed. No complications related to the C-MAC system were observed. CONCLUSIONS Compared to direct laryngoscopy with a Macintosh laryngoscope blade in unselected patients undergoing ENT surgery and thus patients more susceptible to an unexpected difficult airway than a general patient population, the mobile C-MAC video laryngoscope significantly enhanced laryngeal view. Using RAE tracheal tubes seems to compensate the unfavorable deviation of optical and anatomical axes when indirect laryngoscopy is performed with the C-MAC system.


Anaesthesist | 2010

Direkte Laryngoskopie oder C-MAC-Videolaryngoskopie?

Dirk Meininger; U. Strouhal; Christian Weber; D. Fogl; Lars Holzer; Kai Zacharowski; Christian Byhahn

BACKGROUND Previous studies have shown that video laryngoscopy enhances laryngeal view in patients with apparently normal and difficult airways. The utility of the novel, portable, battery-powered C-MAC video laryngoscope is as yet unproven. It was hypothesized that in routine patients undergoing ENT surgery, the rate of glottic views considered unsatisfactory, i.e. Cormack and Lehane grades IIb, III, and IV, could be significantly reduced with the C-MAC video laryngoscope compared to direct laryngoscopy. METHODS Following ethical approval and sample size estimates 108 consecutive patients undergoing ENT surgery under general anesthesia were studied. First, direct laryngoscopy was performed with the naked eye. The best view obtained was graded by the first anesthesiologist without looking at the video monitor. A second anesthesiologist blinded to the laryngeal view obtained under direct laryngoscopy graded the laryngeal view on the video monitor. Endotracheal intubation using Ring-Adair-Elwyn (RAE) tracheal tubes was then attempted under video-aided visualization. The tubes were not reinforced with a stylet. The C-MAC video laryngoscopy system (Karl Storz, Tuttlingen, Germany) is a novel device that can be used with Macintosh laryngoscope blades in different sizes. A camera and light source are located recessed from the tip of the blade. The camera unit sits in a handle attached to the laryngoscope blade and is connected by a wire to a TFT video monitor. It allows for both direct and indirect laryngoscopy and the low profile of the original British Macintosh blades may prove advantageous in patients with limited mouth opening. RESULTS A total of 108 patients were enrolled in the study but for various reasons only 94 completed the study (post hoc power 97%). In 89 patients a size 3 Macintosh laryngoscope was used while a size 4 blade was used in the remaining 5 patients. With direct laryngoscopy the glottic view was considered unsatisfactory in 40 patients (42%), but this was the case in only 15 patients (16%) when video laryngoscopy was used (p<0.0001). Endotracheal tube placement was successful in all but one patient where the Bonfils intubation fiberscope needed to be employed. No complications related to the C-MAC system were observed. CONCLUSIONS Compared to direct laryngoscopy with a Macintosh laryngoscope blade in unselected patients undergoing ENT surgery and thus patients more susceptible to an unexpected difficult airway than a general patient population, the mobile C-MAC video laryngoscope significantly enhanced laryngeal view. Using RAE tracheal tubes seems to compensate the unfavorable deviation of optical and anatomical axes when indirect laryngoscopy is performed with the C-MAC system.


Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie | 2013

Pssst ... AINS-Secrets! – Heute aus der Augenheilkunde

Daniel Gill-Schuster; Pia Ockelmann; Martin Bergold; Lars Holzer; Kai Zacharowski

ASA-Klassifi kation Die Einteilung nach der American Society of Anaesthesiologists (ASA) geht auf das Jahr 1941 zurück. Ein Komitee der ASA beauftragte Saklad, Rovenstine und Taylor eine Kategorisierung anhand von statistischen Auswertungen zu fi nden, die eine perioperative Gruppierung von Patienten bezüglich ihres Operationsrisikos und ihrer Komplikationsrate ermöglichen sollte. Diese Aufgabe wurde von ihnen als nicht lösbar defi niert. Stattdessen entwickelten sie eine 6 PunkteSkala, die eine allgemeine Einstufung des präoperativen Patientenstatus ermöglichte. Sie hoff ten, dass die Anästhesisten Amerikas diese Klassifi kation übernehmen würden. Damit wäre eine statistische Auswertung der Daten bezüglich Letalität und Morbidität von operativen Prozeduren möglich. Die Klassen 1–4 ähnelten den Klassen 1–4 der heutigen Defi nition. In einer Notfallsituation wurden Patienten der Klasse 1–2 in Klasse 5 eingestuft. Vergleichbar wurden Patienten, die normalerweise als Klasse 3 oder 4 Fachwissen: AINS-Secrets


Anaesthesist | 2010

Direkte Laryngoskopie oder C-MAC-Videolaryngoskopie?@@@Direct laryngoscopy or C-MAC video laryngoscopy?: Routineintubation von Patienten in der HNO-Heilkunde@@@Routine tracheal intubation in patients undergoing ENT surgery

Dirk Meininger; U. Strouhal; Christian Weber; D. Fogl; Lars Holzer; Kai Zacharowski; Christian Byhahn

BACKGROUND Previous studies have shown that video laryngoscopy enhances laryngeal view in patients with apparently normal and difficult airways. The utility of the novel, portable, battery-powered C-MAC video laryngoscope is as yet unproven. It was hypothesized that in routine patients undergoing ENT surgery, the rate of glottic views considered unsatisfactory, i.e. Cormack and Lehane grades IIb, III, and IV, could be significantly reduced with the C-MAC video laryngoscope compared to direct laryngoscopy. METHODS Following ethical approval and sample size estimates 108 consecutive patients undergoing ENT surgery under general anesthesia were studied. First, direct laryngoscopy was performed with the naked eye. The best view obtained was graded by the first anesthesiologist without looking at the video monitor. A second anesthesiologist blinded to the laryngeal view obtained under direct laryngoscopy graded the laryngeal view on the video monitor. Endotracheal intubation using Ring-Adair-Elwyn (RAE) tracheal tubes was then attempted under video-aided visualization. The tubes were not reinforced with a stylet. The C-MAC video laryngoscopy system (Karl Storz, Tuttlingen, Germany) is a novel device that can be used with Macintosh laryngoscope blades in different sizes. A camera and light source are located recessed from the tip of the blade. The camera unit sits in a handle attached to the laryngoscope blade and is connected by a wire to a TFT video monitor. It allows for both direct and indirect laryngoscopy and the low profile of the original British Macintosh blades may prove advantageous in patients with limited mouth opening. RESULTS A total of 108 patients were enrolled in the study but for various reasons only 94 completed the study (post hoc power 97%). In 89 patients a size 3 Macintosh laryngoscope was used while a size 4 blade was used in the remaining 5 patients. With direct laryngoscopy the glottic view was considered unsatisfactory in 40 patients (42%), but this was the case in only 15 patients (16%) when video laryngoscopy was used (p<0.0001). Endotracheal tube placement was successful in all but one patient where the Bonfils intubation fiberscope needed to be employed. No complications related to the C-MAC system were observed. CONCLUSIONS Compared to direct laryngoscopy with a Macintosh laryngoscope blade in unselected patients undergoing ENT surgery and thus patients more susceptible to an unexpected difficult airway than a general patient population, the mobile C-MAC video laryngoscope significantly enhanced laryngeal view. Using RAE tracheal tubes seems to compensate the unfavorable deviation of optical and anatomical axes when indirect laryngoscopy is performed with the C-MAC system.


Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie | 2018

Pssst … AINS-Secrets: heute aus der Urologie – TUR-Syndrom

Daniel Gill-Schuster; Martin Bergold; Lars Holzer


Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie | 2017

Pssst … AINS-Secrets: Heute aus der Traumatologie und Orthopädie

Frederike Kresing; Daniel Gill-Schuster; Lars Holzer


Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie | 2017

Erratum: Pssst … AINS-Secrets: Heute aus der Gynäkologie

Sabrina Pflum; Daniel Gill-Schuster; Lars Holzer


Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie | 2016

Pssst ... AINS-Secrets! - Heute aus der Schmerztherapie

Daniel Gill-Schuster; Martin Bergold; Lars Holzer; Kai Zacharowski


Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie | 2016

Pssst ... AINS-Secrets! – Heute aus der individualisierten Anästhesie bei Kindern mit schwierigem Atemweg

Stefanie Eing; Lars Holzer; Daniel Gill-Schuster; Kai Zacharowski

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Kai Zacharowski

Goethe University Frankfurt

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Martin Bergold

Goethe University Frankfurt

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Christian Byhahn

Goethe University Frankfurt

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Dirk Meininger

Goethe University Frankfurt

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Christian Weber

Goethe University Frankfurt

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D. Fogl

Goethe University Frankfurt

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Pia Ockelmann

Goethe University Frankfurt

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U. Strouhal

Goethe University Frankfurt

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Bertram Scheller

Goethe University Frankfurt

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