Manabu Tanoue

High temporal and spatial quality petawatt-class Ti:sapphire chirped-pulse amplification laser system

Optical parametric chirped-pulse amplification (OPCPA) operation with low gain by seeding with high-energy, clean pulses is shown to significantly improve the contrast to better than 10(-10) to 10(-11) in a high-intensity Ti:sapphire laser system that is based on chirped-pulse amplification. In addition to the high-contrast broadband, high-energy output from the final amplifier is achieved with a flat-topped spatial profile of filling factor near 77%. This is the result of pump beam spatial profile homogenization with diffractive optical elements. Final pulse energies exceed 30 J, indicating capability for reaching peak powers in excess of 500 TW.

Application of laser-accelerated protons to the demonstration of DNA double-strand breaks in human cancer cells

We report the demonstrated irradiation effect of laser-accelerated protons on human cancer cells. In vitro (living) A549 cells are irradiated with quasimonoenergetic proton bunches of 0.8–2.4 MeV with a single bunch duration of 15 ns. Irradiation with the proton dose of 20 Gy results in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks generated in the cancer cells. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. Unique high-current and short-bunch features make laser-driven proton bunches an excitation source for time-resolved determination of radical yields.

High-contrast, high-intensity laser pulse generation using a nonlinear preamplifier in a Ti:sapphire laser system

We report a high-contrast, high-intensity Ti:sapphire chirped-pulse amplification system that incorporates a nonlinear preamplifier based on optical parametric chirped-pulse amplification (OPCPA). By cooling the Ti:sapphire crystal in the final amplifier down to 77 K, the chirped-pulses are amplified to 2.9 J at a 10 Hz repetition rate without a thermal lensing effect. Pulse compression down to 19 fs duration obtained after amplification indicates a peak power of 80 TW. With the OPCPA, the temporal contrast is significantly improved to better than 7x10(-9) in a few picoseconds interval prior to the main laser pulse.

Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline

Human cancer cells are irradiated by laser-driven quasimonoenergetic protons. Laser pulse intensities at the 5×1019 W/cm2 level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton irradiation at dose levels of up to 8 Gy, for which the single bunch dose rate is 1×107 Gy/s and the effective dose rate is 0.2 Gy/s for 1 Hz repetition of irradiation. Relative biological effectiveness at the 10% survival fraction is measured to be 1.20±0.11 using protons with a linear energy transfer of 17.1 keV/μm.

High-energy, high-contrast, multiterawatt laser pulses by optical parametric chirped-pulse amplification

We describe a compact, reliable, high-power, and high-contrast noncollinear optical parametric chirped-pulse amplifier system. With a broadband Ti:sapphire oscillator and grating-based stretching and compression, the chirped pulses are amplified from 0.1 nJ to 122 mJ in type I beta-barium borate optical parametric chirped-pulse amplifiers with a total gain of over 10(9) at 10 Hz repetition rate. Pulse compression down to 19-fs duration achieved after amplification indicates a peak power of 3.2 TW at an average power of 0.62 W. The prepulse contrast is measured to be less than 10(-8) on picosecond time scales.

Focusing and spectral enhancement of a repetition-rated, laser-driven, divergent multi-MeV proton beam using permanent quadrupole magnets

A pair of conventional permanent magnet quadrupoles is used to focus a 2.4 MeV laser-driven proton beam at a 1 Hz repetition rate. The magnetic field strengths are 55 and 60 T/m for the first and second quadrupoles, respectively. The proton beam is focused to a spot with a size of less than ∼3×8 mm2 at a distance of 650 mm from the source. This result is in good agreement with the Monte Carlo particle trajectory simulation.

Temporal contrast enhancement of petawatt-class laser pulses

We demonstrate the temporal contrast enhancement in a petawatt-class Ti:sapphire chirped-pulse amplification (CPA) laser system. An extra saturable absorber, introduced downstream after a low-gain optical parametric chirped-pulse amplification (OPCPA) preamplifier, has improved the temporal contrast in the system to 1.4×10(12) on the subnanosecond time scale at 70 TW power level. We have achieved 28 J of uncompressed broadband output energy with this system, indicating the potential for reaching peak powers near 600 TW.

High-spatiotemporal-quality petawatt-class laser system

We have developed a femtosecond high-intensity laser system that combines both Ti:sapphire chirped-pulse amplification (CPA) and optical parametric CPA (OPCPA) techniques and produces more than 30 J broadband output energy, indicating the potential for achieving peak powers in excess of 500 TW. With a cleaned high-energy seeded OPCPA preamplifier as a front end in the system, for the compressed pulse without pumping the final amplifier, we found that the temporal contrast in this system exceeds 10(10) on the subnanosecond time scales, and is near 10(12) on the nanosecond time scale prior to the peak of the main femtosecond pulse. Using diffractive optical elements for beam homogenization of a 100 J level high-energy Nd:glass green pump laser in a Ti:sapphire final amplifier, we have successfully generated broadband high-energy output with a near-perfect top-hat-like intensity distribution.

Proton-induced Nuclear Reactions Using Compact High-Contrast High-Intensity Laser

A multi-MeV proton beam driven by a compact laser with an intensity of ?1020 W/cm2 is used to induce the nuclear reaction 11B(p,n)11C. The total activity of 11C produced after 60 shots of laser irradiation is found to be 11.1?0.4 Bq. The possibility of thin layer activation (TLA) analysis using a high-intensity ultrashort-pulse laser is discussed.

Simultaneous Proton and X-ray Imaging with Femtosecond Intense Laser Driven Plasma Source

A laser-driven proton beam with a maximum energy of a few MeV is stably obtained using an ultra-short and high-intensity Ti:sapphire laser. At the same time, keV X-ray is also generated at almost the same place where protons are emitted. Here, we show the successful demonstration of simultaneous proton and X-ray projection images of a test sample placed close to the source with a resolution of ~10 µm, which is determined from the source sizes. Although the experimental configuration is very simple, the simultaneity is better than a few hundreds of ps. A CR-39 track detector and imaging plate, which are placed as close as possible to the CR-39, are used as detectors of protons and X-ray. The technique is applicable to the precise observation of microstructures.