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Mitsuhiro Ueno

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Publication

Featured researches published by Mitsuhiro Ueno.

International Journal of Immunopharmacology | 1995

Low molecular weight immunomodulators produced by microorganisms

Masaaki Ishizuka; Masaji Kawatsu; Takashi Yamashita; Mitsuhiro Ueno; Tomio Takeuchi

Immunomodulatory and antitumor activities of the low molecular weight, microbially-derived immunomodulators, bestatin and forphenicinol are reviewed. In addition, the inhibitory effects of the antitumor antibiotics, aclacinomycin and oxanosine, on the generation of suppressor cells are also represented. It is suggested that these substances will be useful for cancer treatment by chemotherapy and/or immunotherapy.

Journal of Pharmacology and Experimental Therapeutics | 2004

IC101 Induces Apoptosis by Akt Dephosphorylation via an Inhibition of Heat Shock Protein 90-ATP Binding Activity Accompanied by Preventing the Interaction with Akt in L1210 Cells

Hironori Fujiwara; Tohru Yamakuni; Mitsuhiro Ueno; Masaaki Ishizuka; Takashi Shinkawa; Toshiaki Isobe; Yasushi Ohizumi

The Journal of Antibiotics | 1994

Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I: Taxonomy, fermentation, isolation and biological activities

Masahide Amemiya; Mitsuhiro Ueno; Michiyo Osono; Tohru Masuda; Naoko Kinoshita; Chigusa Nishida; Mawa Hamada; Masaaki Ishizuka; Omio Takeuchi

The Journal of Antibiotics | 1993

IC101, extracellular matrix antagonist produced by Streptomyces sp. MJ202-72F3 : production, isolation, structure determination and biological activity

Mitsuhiro Ueno; Masahide Amemiya; Tetsuya Someno; Toru Masuda; Hironobu Iinuma; Hiroshi Naganawa; Masa Hamada; Masaaki Ishizuka; Tomio Takeuchi

The Journal of Antibiotics | 1993

Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. I: Taxonomy, fermentation, isolation and biological activity

Mitsuhiro Ueno; Masahide Amemiya; Masatomi Iijima; Michiyo Osono; Toru Masuda; Naoko Kinoshita; Takako Ikeda; Hironobu Iinuma; Masa Hamada; Masaaki Ishizuka; Tomio Takeuchi

The Journal of Antibiotics | 1993

Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. II: Physico-chemical properties and structure elucidation of delaminomycin A

Mitsuhiro Ueno; Tetsuya Someno; Ryuichi Sawa; Hironobu Iinuma; Hiroshi Naganawa; Masaaki Ishizuka; Tomio Takeuchi

Archive | 1993

Antibiotics having immunosuppressive activity, delaminomycins and processes for the production of the same

Masaaki Ishizuka; Mitsuhiro Ueno; Hironobu Iinuma; Hiroshi Naganawa; Masa Hamada; Kenji Maeda; Tomio Takeuchi

The Journal of Antibiotics | 1992

Dethymicin, a novel immunosuppressant isolated from an Amycolatopsis : fermentation, isolation, physico-chemical properties and biological activities

Mitsuhiro Ueno; Masatomi Iijima; Toru Masuda; Naoko Kinoshita; Hironobu Iinuma; Hiroshi Naganawa; Masa Hamada; Masaaki Ishizuka; Tomio Takeuchi

The Journal of Antibiotics | 1993

Delaminomycins, novel extracellular matrix receptor antagonist.:IV. STRUCTURE-ACTIVITY RELATIONSHIPS OF DELAMINOMYCINS AND DERIVATIVES

Mitsuhiro Ueno; Masahide Amemiya; Katsuhisa Yamazaki; Masatomi Iijima; Michiyo Osono; Tetsuya Someno; Hironobu Iinuma; Masa Hamada; Masaaki Ishizuka; Tomio Takeuchi

The Journal of Antibiotics | 1993

Delaminomycins, novel extracellular matrix receptor antagonist. III. Physico-chemical properties and structure elucidation of delaminomycins B and C.

Mitsuhiro Ueno; Tetsuya Someno; Ryuichi Sawa; Hironobu Iinuma; Hiroshi Naganawa; Masaaki Ishizuka; Tomio Takeuchi

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Collaboration

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Tomio Takeuchi

Keio University

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Hironobu Iinuma

Kitasato University

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Masaaki Ishizuka

Bristol-Myers Squibb

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Hiroshi Naganawa

Gunma University

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Masa Hamada

Hiroshima University

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Tetsuya Someno

Keio University

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Toru Masuda

Takeda Pharmaceutical Company

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Masaaki Ishizuka

Bristol-Myers Squibb

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Kenji Maeda

National Institutes of Health

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Hironori Fujiwara

Tohoku University

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