Mukul Kumar Gupta

Zingiber officinale exhibits behavioral radioprotection against radiation-induced CTA in a gender-specific manner

At the organismic level, exposure to radiation can produce taste aversion (CTA) learning and emesis, which have been proposed as behavioral endpoints that are mediated by harmful effects of radiations on peripheral systems, primarily the gastrointestinal system. Thus, the aim of the present investigation was to study the gastroprotective action of hydroalcoholic extract of zingiber rhizome (Zingiber officinale Rosc.) against radiation-induced conditioned taste aversion (CTA) in both male and female species of animals, for testing its potential as a behavioral radioprotector. Administration of zingiber extract 1 h before 2-Gy gamma-radiation was significantly effective in blocking the saccharin avoidance response, with 200 and 250 mg/kg b.wt. i.p., being the most effective doses for male and female rats, respectively. A comparison of the efficacy of zingiber extract with two antiemetic drugs, ondansteron and dexamethasone, revealed that the extract rendered comparable protection against radiation-induced CTA. Our experiments also confirmed the existence of sex dichotomy (i.e., the sex of animal greatly influenced response towards radiation exposure) in relation to behavioral responses (CTA) or differential metabolism. The observed gender variations were hypothesized to be a result of hormonal fluctuations and differences in pharmacological parameters in male and female rats. To correlate the mechanism of action, the free-radical-scavenging potential of zingiber extract to scavenge hydroxyl ion and nitric oxide was also tested, in cell-free system and a concentration of 1000 microg/ml, was found to be the most potent, which has been proposed as one the many activities assisting in its overall ability to modulate radiation-induced taste aversion. The results demonstrate that Z. officinale possesses antioxidant, radioprotective and neuromodulatory properties that can be effectively utilized for behavioral radioprotection and for efficiently mitigating radiation-induced CTA in both males and females species.

Evaluation of Analgesic, Antipyretic Activity and Toxicity Study of Bryonia laciniosa in Mice and Rats

Analgesic, antipyretic activity and toxicity study of the leaves of Bryonia laciniosa Linn. (Family: Cucurbitaceae) was evaluated in the standard animal models. The methanol extract of Bryonia laciniosa (MEBL) was evaluated by hot plate and acetic acid-induced writhing methods to assess analgesic activity. The antipyretic activity of the extract was also evaluated by normal body temperature and yeast-induced hyperpyrexia. The extract showed significant analgesic and antipyretic activity. The MEBL was further evaluated for toxicity at the doses of 125 and 250 mg/kg administered orally for 14 days in rats. At the end of experiments, the blood, liver function and kidney metabolism were observed. The hematological profile and different biochemical parameters such as SGOT, SGPT and ALP were estimated. The present study revealed that MEBL exhibited significant analgesic and antipyretic activity in the tested experimental animal models. The toxicity study indicates that the extract is not toxic at the tested doses.

Stabilization of triple link inverted pendulum system based on LQR control technique

This paper first discusses the mathematical modeling of a dynamical system consists of triple link inverted pendulum (TLIP) on a moving cart using Lagrangian equation. This model is then used to design a controller based on the LQR method to maintain the TLIP vertically on the moving cart. The stability and controllability of the triple link inverted pendulum system are investigated and the choice of weights in LQR is also discussed. The system is simulated in MATLAB environment and the simulation results establish the satisfactory performance of the LQR controller in stabilizing the system.

HAAR like Feature-Based Car Key Detection Using Cascade Classifier

The paper reports effective real-time implementation for specific object detection in an image or sequence of images. For the present work, car key has been taken as an object under consideration. The classifier is developed using OpenCV-Python. The procedure encompasses training and detection. A wide variety of object images are used for training purpose. The developed xml classifier is then tested on separate test images. The classifier has a good success rate with minimal false object detection rate.

Mass and Length Dependent Chaotic Behavior of a Double Pendulum

Abstract In this article, chaotic behavior of a double pendulum (DP) is studied numerically by varying its mass and length. The results are analyzed using time series plot, Poincare map and Lyapunov exponent plot. It is observed that the chaotic tendency of the DP increases with mass and length. However, both pendulums of the DP have varying effect on the Lyapunov exponent. The significance of the present study in the optimization and control of the dynamical systems based on the DP is also discussed.

FM Receiver Design Using Programmable PLL

The research article presents the design of different components of FM receiver. The design approach is based on digital components rather than analog components such as phase detector, loop filter and voltage controlled oscillator. The signal is presented using digital words instead of analog voltages. In digital FM receiver, PLL is the main part to capture and lock the signals at different frequency and phase. The main purpose of PLL is to maintain the coherence between the modulated signal frequency (fi) and the respective frequency (fo), with the concept of phase comparison. PLL permits to track the frequency changes of applied input signals, as it is locked once. There is a use of 8 bit analog to digital conversion circuit, which is accepting frequency modulated signal as a series of digital numerical values. The same signals are demodulated by the receiver on every clock cycle. The paper proposed the design and FPGA implementation of digital PLL and programmable all FM receiver. The design is developed in Xilinx 14.2 ISE software and simulated in Modelsim 10.1b software with the help of VHDL programming language and the targeted onVirtex-5 FPGA.

Trajectory Tracking Control of Robot Manipulators

In this paper a simulink based approach is developed for trajectory tracking of robot manipulator. A robot manipulator is widely used in many industrial application.A robot manipulator moves the end effector to the configuration instructed by the user. The input from the main unit is transformed in to the desired configuration through forward kinematics. This configuration is sent to the robot controller to transform the configuration into joint angles. The simulink model is developed to provide basic block to model kinematics and trajectory tracking of robot manipulator. Availability of such library model of robot manipulator software, where the manipulator controller can be modelled using model library blocks and production can be automatically generated using existing code generators for simulink. In this the desired and the actual trajectory of the end effector under different conditions is shown with the help of MATLAB simulation.

Speed Regulation of a Non-linear Separately Excited DC Motor Using Optimized Fuzzy Logic Control

This paper demonstrates the speed tracking for a separately excited non-linear DC motor using optimized fuzzy logic controller. Rotor speed is varied by changing the armature voltage of the motor while keeping the voltage in the constant torque region. Genetic algorithms optimization-based fuzzy logic control is used to track the speed change, and the results obtained from fuzzy logic control are compared with PID controller. Comparison indicate an improvement in performance for optimized fuzzy logic control exhibiting a reduction in overshoot, transient, and steady-state parameters as compared with PID controller.

Inductive Power as Wireless Energy in Electrical Applications

Nowadays, every single person is using mobile phones which became the integral part of their lives. It gives access to internet, movies, videos and books also. Using internet 3G or 4G gives heavy load to the battery which gets discharged soon. If a man using a smartphone and using all of these features then it gives an average of seven hours of battery life. After these seven hours, battery will be discharged. What will a person do when he is travelling and the battery of his smartphone get discharged. As technology improves, we should have a solution to this problem. So a wireless energy transfer car charger can be a solution to this problem. The paper focuses on the wireless charging theoretical aspects and its successful testing environment.

Automatic Forest Fire Detection and Monitoring Techniques: A Survey

Natural disasters have always been mankind’s constant companion since time immemorial. Forest fire is one such disaster which when occurs at large scale not only destroys the flora, fauna, vegetation of the forest but also puts the life of human being and animals at a very high risk. In the recent past years, managing this type of crisis, viz., a large scale fire has become a very difficult and challenging task. Things that are common in most of the forest fire that occur at large scale are loss of life (human or animal), loss of vegetation, loss of flora and fauna, and communication failure. Therefore, a comprehensive survey on the existing forest fire detection and monitoring mechanisms is highly desired. This article is aimed at providing a birds eye view of these existing detection and monitoring mechanisms for forest fires.