P. Perumal

Evaluation of Analgesic, Antipyretic Activity and Toxicity Study of Bryonia laciniosa in Mice and Rats

Analgesic, antipyretic activity and toxicity study of the leaves of Bryonia laciniosa Linn. (Family: Cucurbitaceae) was evaluated in the standard animal models. The methanol extract of Bryonia laciniosa (MEBL) was evaluated by hot plate and acetic acid-induced writhing methods to assess analgesic activity. The antipyretic activity of the extract was also evaluated by normal body temperature and yeast-induced hyperpyrexia. The extract showed significant analgesic and antipyretic activity. The MEBL was further evaluated for toxicity at the doses of 125 and 250 mg/kg administered orally for 14 days in rats. At the end of experiments, the blood, liver function and kidney metabolism were observed. The hematological profile and different biochemical parameters such as SGOT, SGPT and ALP were estimated. The present study revealed that MEBL exhibited significant analgesic and antipyretic activity in the tested experimental animal models. The toxicity study indicates that the extract is not toxic at the tested doses.

Anti-inflammatory and Antimicrobial activities of Petroleum ether and Ethanol extracts of Scutia myrtina (Rhamnaceae)

SUMMARY The aim of the present study is to investigate the anti-inflammatory and antimicrobial activity ofpetroleum ether and ethanol extracts of Scutia myrtina (Family: Rhamnaceae). In anti-inflammatory activity carrageenan and histamine induced paw oedema and cotton pellet inducedgranuloma for acute and chronic inflammatory models were studied in Wister albino rats. Basedon the results of the present study it can be concluded that petroleum ether and ethanol extract ofScutia myrtina at 400 mg/kg has potential anti-inflammatory effect and they act in a dosedependent manner. Both extracts of Scutia myrtina showed antimicrobial activity against allbacterial and fungal strains tested at the concentration of 100 µg/ml. From the result, it can beconcluded that the Scutia myrtina contain antibacterial and antifungal principle. Further more,besides the confirmation of the popular use; the obtained results demonstrate this herbal drug torepresent a new source of antimicrobial and anti-inflammatory agent.Key words: Scutia myrtina; Anti-inflammatory; Experimental animal; Antimicrobial activity