Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Paul Hrvatin.
Journal of Medicinal Chemistry | 2013
Paul A. Roethle; Ryan Mcfadden; Hong Yang; Paul Hrvatin; Hon C. Hui; Michael Graupe; Brian M. Gallagher; Jessica Jade Chao; Joseph Hesselgesser; Paul Duatschek; Jim Zheng; Daniel B. Tumas; Jason K. Perry; Randall L. Halcomb
Pteridinone-based Toll-like receptor 7 (TLR7) agonists were identified as potent and selective alternatives to the previously reported adenine-based agonists, leading to the discovery of GS-9620. Analogues were optimized for the immunomodulatory activity and selectivity versus other TLRs, based on differential induction of key cytokines including interferon α (IFN-α) and tumor necrosis factor α (TNF-α). In addition, physicochemical properties were adjusted to achieve desirable in vivo pharmacokinetic and pharmacodynamic properties. GS-9620 is currently in clinical evaluation for the treatment of chronic hepatitis B (HBV) infection.
Archive | 2011
Kerim Babaoglu; Elizabeth M. Bacon; Kyla Bjornson; Hongyan Guo; Randall L. Halcomb; Paul Hrvatin; John O. Link; Hongtao Liu; Ryan Mcfadden; Michael L. Mitchell; Paul A. Roethle; James Taylor; James D. Trenkle; Randall W. Vivian; Lianhong Xu
Archive | 2013
Kerim Babaoglu; Gediminas Brizgys; Hongyan Guo; Paul Hrvatin; Eric Lansdon; John O. Link; Hongtao Liu; Ryan Mcfadden; Michael L. Mitchell; Yingmei Qi; Paul A. Roethle; Randall W. Vivian; Lianhong Xu; Hong Yang
Archive | 2013
Kerim Babaoglu; Kyla Bjornson; Paul Hrvatin; Eric Lansdon; John O. Link; Hongtao Liu; Ryan Mcfadden; Michael L. Mitchell; Yingmei Qi; Paul A. Roethle; Lianhong Xu
Archive | 2009
Manoj C. Desai; Randall L. Halcomb; Paul Hrvatin; Hon C. Hui; Ryan Mcfadden; Paul A. Roethle; Hong Yang
Archive | 2017
Paul A. Roethle; Paul Hrvatin; Randall L. Halcomb; Jessica Jade Chao; Richard Hung Chiu Yu; Hong Yang; Erwina Rudio; Ryan Mcfadden; Brandon Heath Brown; Darin Allen
Archive | 2015
Darin Allen; Brandon Heath Brown; Jessica Jade Chao; Randall L. Halcomb; Paul Hrvatin; Ryan Mcfadden; Paul A. Roethle; Erwina Rudio; Hong Yang; Richard Hung Chiu Yu
Archive | 2014
Desai Manoj C; Randall L. Halcomb; Paul Hrvatin; Hui Hon Chung; Ryan Mc Fadden; Paul A. Roethle; Yang Hong
Archive | 2013
Kerim Babaoglu; Kyla Bjornson; Paul Hrvatin; Eric Lansdon; John O. Link; Hongtao Liu; Ryan Mcfadden; Michael L. Mitchell; Yingmei Qi; Paul A. Roethle; Lianhong Xu
Archive | 2010
Desai Manoj C; Halcomb Randall L; Paul Hrvatin; Hui Hon Chung; Ryan Mcfadden; Roethle Paul A; Hong Yang
