S. Rana Varol

Effects of aerobic training on serum paraoxonase activity and its relationship with PON1-192 phenotypes in women

Background Paraoxonase 1 (PON1) is an antioxidant enzyme that protects high-density lipoprotein (HDL) and low-density lipoprotein against oxidation. Limited studies have addressed the influence of exercise on PON1 activity and its relationship with PON1 phenotypes. We investigated relationships between PON1-192 phenotypes, PON1 activity, aerobic exercise, and blood lipid and lipoprotein concentrations in middle-aged women. Methods An exercise group (n = 50) engaging in regular aerobic exercise and a control group (n = 41) were selected from a subset of 300 Caucasian women that met the inclusion criteria. Serum PON1, salt-stimulated PON1 (SSPON1), and arylesterase (ARE) activities; cholesterol levels and ARE activities of total HDL and HDL subgroups (HDLs) (supernatants obtained by polyethylene glycol); and blood lipid and lipoprotein concentrations were determined by standardized enzymatic methods. PON1-192 QQ (low activity), QR (moderate activity), and RR (high activity) phenotype groups were defined using serum SSPON1/ARE activity ratios. The R-carries (RC) phenotype group consisted of the QR and RR groups combined. Results All lipid and lipoprotein concentrations were greater in the exercise group than in the control group. Regardless of phenotype, no significant differences were observed between the exercise and control groups in terms of serum PON1, SSPON1, or ARE activity associated with HDLs (p > 0.05), whereas PON1 activities in QQ-phenotyped women in the exercise group were significantly higher than those in the control group (p < 0.01), but not the RC group. A statistically significant interaction between PON1 phenotypes (QQ and RC groups) and exercise (exercise and control groups) on PON1 activity was found. Conclusion These results showed that a regular aerobic exercise program can improve PON1 activity depending on PON1-192 phenotype, but not on lipid and lipoprotein levels, in middle-aged Turkish women.

O-41 Determination of maximal oxygen uptake through a new basketball-specific field test

Objectives The aim of this study was to develop a new “basketball specific field test” that determines the maximal oxygen uptake indirectly and to determine reliability and validity of the test for measuring aerobic power. Methods A total of 1.5 mile (2240 m) -aerobic endurance test on a basketball court including the side steps on the three-point line and running on the side-line was designed to be completed as soon as possible. Healthy, 15 years old, 11 male basketball players’ (training background is 5.18 years, body mass 84.4 kg, height 190.3 cm) participated. Results Maximal oxygen uptake (VO2max) levels measured directly in the laboratory as gold standard test showed a significant negative correlation with the duration of basketball-specific field test (r = −0.705, p = 0.015). The regression analysis through a new “basketball-specific field test” proved moderate validity (r = 0.390), then regression formula was developed to estimate VO2max level: VO2max = 122.617 – 5.461 x [basketball-specific field test duration (min)]. Reliability was evaluated by test-retest method, there was no difference between duration of a new “basketball specific field test” (p > 0.05) repeated at intervals and it showed high reliability (% CV: 8.81 and ICC: 0.90). Conclusions A new “basketball specific field test”, which proved reliability and validity to measure aerobic power indirectly, may be considered to help coaches and athletes by means of its properties which ensure easy and practical application by using simple basketball-specific movements in basketball courts, not to require expensive equipment and specialist staff, and not to have any health risks.

Vitamin D ve Metabolik Fonksiyonları

Vitamin D,insanoglu icin en onemli vitaminlerden biridir ve ihtiyacinin %95’i gunes isinlarinin cilde sentezlenmesiyle karsilanir.Vitamin D eksikligi ozellikle kanser gibi bir cok hastaliga yol acabilecegi icin,yeterli bir seviyede vitamin D alanlar eger egzersiz yaparlarsa bu riski azaltabilirler.Ayni zamanda vitamin D seviyesi yuksek olursa,leptin hormonu sayesinde daha az yemek yenecegi icin obezite riski minimuma inecektir.Vitamin D reseptorleri yaklasik olarak 40 dokuda vardir.Yagda cozunen vitamin D’nin en onemli etkisi kemik minerilizasyonu fosfor metabolizmasi ve kalsiyum uzerinedir.Vitamin D seviyesi dusuk olan kisiler,yardimci ilaclar yerine vitamin D acisindan zengin olan kaynaklarin besinlerinden sendromlar,bulasici,otoimmun ve kardiyovaskuler gibi bir cok hastalikla iliskisi oldugu bildirilmistir.Gozlemsel calismalarda,endustrilesmis ulkeler de dahil olmak uzere dunyanin kuzey bolgelerinde vitamin D eksikliginin cok yaygin oldugu anlasilmistir

Trombosit Yönünden Zenginleştirilmiş Plazmaya Genel Bir Bakış

Bu bilimsel makalenin amaci, trombosit yonunden zenginlestirilmis plazma (PRP, Platelet Rich Plasma) ile tedavi yontemini daha once hic duymamis insanlara tanitmaktir. Insanlar sakatlanabilir, boylece bedenlerinde doku zedelenmeleri yasanabilir; ornegin kemik kirigi, kucuk yaralanma ya da yarali bir bolge olusabilir. Ayrica hasarli doku iyilesmesi cok uzun zaman alan bir kikirdak doku olabilir. Damarda trombus olarak bulunan trombositler, hasarli dokularini onarmak icin ortaya cikarlar. Bununla birlikte, kisa bir surede trombositler hasarli alanin tedavisi icin yeterli olacaklardir. Bu noktada PRP tedavi yontemi iyilesme surecine bir el verir. Ozel kitlerle santrifuj edilen insanlarin kanlarinda trombosit, kan hucreleri ve plazmadan ayristirilabilir. Bu ayristirilmis plazmanin trombosit yogunlugu, kandaki trombosit yogunlugundan 3-5 kat daha fazladir. Daha sonra hasarli bolgeye ya da dokuya plazma enjeksiyonu ile PRP yontemi uygulanir. Haftada 2-4 seans uygulanmasi sonrasinda, hasarli doku yenilenebilir. Yogunlastirilmis trombosit plazmasi kullanildigi icin bu hizli bir iyilesme yontemidir; bu plazma insanin kendi kanindan elde edildigi icin de guvenli bir yontemdir. PRP bircok alanda uygulanabilir; dis hekimligi, spor hekimligi ile plastik, damar ya da ortopedik gibi farkli tur cerrahi alanlari ornek gosterilebilir. Futbolcularin bacaklari kirildiginda spor hayatlarinin sonuna gelirlerdi. Eger kirilan bacaklari daha iyi ve daha hizli iyilestirilmis olsaydi spor hayatlari yine de biter miydi? Ozetle PRP’ yi, gelecegin guvenli tedavi yontemi olarak tanimlayabiliriz