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Dive into the research topics where Stephen R Bertenshaw is active.

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Featured researches published by Stephen R Bertenshaw.


Bioorganic & Medicinal Chemistry Letters | 1993

Thiol and hydroxamic acid containing inhibitors of endothelin converting enzyme

Stephen R Bertenshaw; John J. Talley; Roland S. Rogers; Jeffrey S Carter; William M. Moore; Linda M. Branson; Carol M. Koboldt

Abstract A group of peptido-mimetic molecules containing either a thiol or hydroxamic acid moiety were synthesized and evaluated for in vitro inhibition of a putative endothelin converting enzyme (ECE) partially purified from rabbit lung membranes. These compounds were envisioned as analogs of the phosphoramide containing metalloprotease inhibitor phosphoramidon.


Journal of Medicinal Chemistry | 2000

N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration.

John J. Talley; Stephen R Bertenshaw; David L. Brown; Jeffery S Carter; Matthew J. Graneto; Michael S. Kellogg; Carol M. Koboldt; Jinhua Yuan; and Yan Y. Zhang; Karen Seibert


American Journal of Hypertension | 1993

Effect of Phosphoramidon (Endothelin Converting Enzyme Inhibitor) and BQ-123 (Endothelin Receptor Subtype A Antagonist) on Blood Pressure in Hypertensive Rats

Ellen G. Mcmahon; Maria A. Palomo; Melanie A. Brown; Stephen R Bertenshaw; Jeffery S. Carter


Journal of Medicinal Chemistry | 1993

Phosphorus-containing inhibitors of endothelin converting enzyme: effects of the electronic nature of phosphorus on inhibitor potency

Stephen R Bertenshaw; Roland S. Rogers; Michael K. Stern; Bryan H. Norman; William M. Moore; Gina M. Jerome; Linda M. Branson; John F. McDonald; Ellen G. Mcmahon; Maria A. Palomo


Archive | 1995

Substituted pyrazolyl benzenesulfonamides for the treatment of gastrointestinal conditions

John J. Talley; Thomas D. Penning; Paul W. Collins; Donald J Rogier; James W. Malecha; Julie M. Miyashiro; Stephen R Bertenshaw; Ish K. Khanna; Matthew J. Graneto; Roland S. Rogers; Jeffery S Carter


Archive | 1994

Benz G! indazolyl derivatives for the treatment of inflammation

John J. Talley; Stephen R Bertenshaw; Roland S. Rogers


Archive | 2002

SUBSTITUTED BEBZENESULFONAMIDE DERIVATIVE AS PRODRUG OF COX-2 INHIBITOR

Stephen R Bertenshaw; David L. Brown; Jeffery S Carter; Matthew J. Graneto; Ish K. Khanna; Jinglin Li; James W. Malecha; Srinivasan Nagarajan; Thomas D. Penning; Jr Donald J Rogier; John J. Talley; Richard M. Weier; Xiangdong Xu; イシュ,ケイ.クハンナ; クシアンドン・イクス; ジェームズ,ダブリュ.メールチャ; ジェフリー,エス.カーター; ジョン,ジェイ.タリイ; ジングリン・リー; スチーブン・バーテンショー; スリニバサン・ナガラジャン; デビッド,エル.ブラウン; ドナルド,ジェイ.ロジャー,ジュニア.; トマス,ディ.ペニング; マシュー,ジェイ.グレナト; リチャード,エム.ウエイアー


Archive | 1997

Substituierte Benzensulfonamid-Derivate als Wirkstoff-Vorläufer von COX-2 Inhibitoren

James W. Malecha; Thomas D. Penning; Ish K. Khanna; Xiangdong Xu; Richard M. Weier; John J. Talley; Stephen R Bertenshaw; Matthew J. Graneto; Jeffrey S Carter; Jinglin Li; Srinivasan Nagarajan; David L. Brown; Donald J Rogier


Archive | 2003

Substituted pyrazolylbenzenesulfonamide for treating inflammation

Stephen R Bertenshaw; Jeffery S Carter; Paul W. Collins; Stephen H Dr; Matthew J Granets; Ish K. Khanna; James W. Malecha; Julie M. Miyashiro; Thomas D. Penning; Roland S. Rogers; Jr Donald J Rogier; John J. Talley; Stella S. Yu; カーター,ジェフリー,エス.; カンナ,イシュ,ケイ.; グラネッツ,マシュー,ジェイ.; コリンズ,ポール,ダブリュ.; タリー,ジョン,ジェイ.; ドクター,スチーブン,エイチ.; バーテンショウ,スチーブン,アール.; ペンニング,トーマス,ディー.; マレチャ,ジェームズ,ダブリュ.; ミヤシロ,ジュリー,エム.; ユ,ステラ,エス.; ロジャー,ドナルド,ジェイ.,ジュニア.; ロジャーズ,ローランド,エス.


Archive | 2000

Asendatud bensopüraani derivaadid põletiku raviks

David L. Brown; Jeffery S Carter; Mark G. Obukowicz; Balekudru Devadas; John J. Talley; Matthew J. Graneto; Stephen R Bertenshaw; Donald J Rogier; Srinivasan Nagarajan; Cathleen E. Hanau; Susan J. Hartmann; Cindy L. Ludwig; Suzanne Metz

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