Thomas M. Bridges | Researchain

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Featured researches published by Thomas M. Bridges.

Archive | 2010

Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM)

L. Michelle Lewis; Thomas M. Bridges; Colleen M. Niswender; C. David Weaver; Craig W. Lindsley

Archive | 2013

Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5

Alice L. Rodriguez; James C. Tarr; Ya Zhou; Richard Williams; Karen J. Gregory; Thomas M. Bridges; J. Scott Daniels; Colleen M. Niswender; P. Jeffrey Conn; Craig W. Lindsley; Shaun R. Stauffer

Archive | 2013

Pure Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction

Ya Zhou; Aspen Chun; Rocco D. Gogliotti; Eric S. Dawson; Paige N. Vinson; Colleen M. Niswender; Meredith J. Noetzel; Jerri M. Rook; Thomas M. Bridges; J. Scott Daniels; Carrie K. Jones; P. Jeffrey Conn; Craig W. Lindsley; Shaun R. Stauffer

Archive | 2010

Amidobipiperidinecarboxylate m1 allosteric agonists, analogs and derivatives thereof, and methods of making and using same

Craig W. Lindsley; Jeffrey P. Conn; Charles David Weaver; Colleen M. Niswender; Evan P. Lebois; Thomas M. Bridges

Archive | 2013

Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity

Thomas M. Bridges; Colleen M. Niswender; Carrie K. Jones; L. Michelle Lewis; C. David Weaver; Michael R. Wood; J. Scott Daniels; P. Jeffrey Conn; Craig W. Lindsley

Archive | 2013

Identification of a Selective Allosteric Agonist of mGlu5

Jason Manka; Ya Zhou; Aspen Chun; Eric S. Dawson; Paige N. Vinson; Colleen M. Niswender; Meredith J. Noetzel; Jerri M. Rook; Thomas M. Bridges; J. Scott Daniels; Carrie K. Jones; P. Jeffrey Conn; Craig W. Lindsley; Shaun R. Stauffer

Archive | 2015

Development of the First CNS penetrant M5 Positive Allosteric Modulator (PAM) Based on a Novel, non-Isatin Core

Patrick R. Gentry; Masaya Kokubo; Thomas M. Bridges; J. Scott Daniels; Colleen M. Niswender; Emery Smith; Peter Chase; Peter Hodder; Hugh Rosen; P. Jeffrey Conn; Julie L. Engers; Katrina A. Brewer; Craig W. Lindsley; Michael R. Wood

Archive | 2013

Figure 4, HTS single-point hit

Patrick R. Gentry; Thomas M. Bridges; J. Scott Daniels; Atin Lamsal; Paige N. Vinson; Colleen M. Niswender; Peter Hodder; Hugh Rosen; P. Jeffrey Conn; Julie L. Engers; Craig W. Lindsley; Michael R. Wood

Archive | 2013