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Brenda A. Ley

Pennsylvania State University

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Featured researches published by Brenda A. Ley.

Biochemistry | 1998

O2 ACTIVATION BY NON-HEME DIIRON PROTEINS : IDENTIFICATION OF A SYMMETRIC MU -1,2-PEROXIDE IN A MUTANT OF RIBONUCLEOTIDE REDUCTASE

Pierre Moënne-Loccoz; Jeffrey W. Baldwin; Brenda A. Ley; Thomas M. Loehr; Bollinger Jm

Journal of the American Chemical Society | 2000

Mechanism of Rapid Electron Transfer during Oxygen Activation in the R2 Subunit of Escherichia coli Ribonucleotide Reductase. 1. Evidence for a Transient Tryptophan Radical

Jeffrey W. Baldwin; Carsten Krebs; Brenda A. Ley; Dale E. Edmondson; and Boi Hanh Huynh; J. Martin Bollinger

Journal of the American Chemical Society | 1998

ENGINEERING THE DIIRON SITE OF ESCHERICHIA COLI RIBONUCLEOTIDE REDUCTASE PROTEIN R2 TO ACCUMULATE AN INTERMEDIATE SIMILAR TO HPEROXO, THE PUTATIVE PER OXODIIRON(III) COMPLEX FROM THE METHANE MONOOXYGENASE CATALYTIC CYCLE

J. M. Bollinger; Carsten Krebs; A. Vicol; Shuxian Chen; Brenda A. Ley; Dale E. Edmondson; Boi Hanh Huynh

Journal of the American Chemical Society | 2001

Rational Reprogramming of the R2 Subunit of Escherichia coli Ribonucleotide Reductase into a Self-Hydroxylating Monooxygenase

Jeffrey W. Baldwin; Walter C. Voegtli; Nelly Khidekel; Pierre Moënne-Loccoz; Carsten Krebs; Alice S. Pereira; Brenda A. Ley; Boi Hanh Huynh; Thomas M. Loehr; Pamela J. Riggs-Gelasco; and Amy C. Rosenzweig; J. Martin Bollinger

Journal of the American Chemical Society | 2000

Mechanism of Rapid Electron Transfer during Oxygen Activation in the R2 Subunit of Escherichia coli Ribonucleotide Reductase. 2. Evidence for and Consequences of Blocked Electron Transfer in the W48F Variant

Carsten Krebs; Shuxian Chen; Jeffrey W. Baldwin; Brenda A. Ley; Utpal Patel; Dale E. Edmondson; Boi Hanh Huynh; J. Martin Bollinger

Journal of the American Chemical Society | 2000

Crystal structure of the ribonucleotide reductase R2 mutant that accumulates a μ-1,2-peroxodiiron(III) intermediate during oxygen activation

Walter C. Voegtli; Nelly Khidekel; Jeffrey W. Baldwin; Brenda A. Ley; J. Martin Bollinger; Amy C. Rosenzweig

Biochemistry | 1998

Electron injection through a specific pathway determines the outcome of oxygen activation at the diiron cluster in the F208Y mutant of Escherichia coli ribonucleotide reductase protein R2.

S. E. Parkin; Shuxian Chen; Brenda A. Ley; L. Mangravite; Dale E. Edmondson; Boi Hanh Huynh; J. M. Bollinger

Journal of the American Chemical Society | 1997

Differential Iron(II) Affinity of the Sites of the Diiron Cluster in Protein R2 of Escherichia coli Ribonucleotide Reductase: Tracking the Individual Sites through the O2 Activation Sequence

J. M. Bollinger; Shuxian Chen; S. E. Parkin; L. M. Mangravite; Brenda A. Ley; Dale E. Edmondson; Boi Hanh Huynh

Journal of the American Chemical Society | 2000

Spectroscopic and Electronic Structure Description of the Reduced Binuclear Non-Heme Iron Active Site in Ribonucleotide Reductase fromE.coli: Comparison to Reduced Δ9Desaturase and Electronic Structure Contributions to Differences in O2Reactivity

Yi-Shan Yang; Jeffrey W. Baldwin; Brenda A. Ley; J. Martin Bollinger; Edward I. Solomon

Biochemistry | 2004

Use of a Chemical Trigger for Electron Transfer to Characterize a Precursor to Cluster X in Assembly of the Iron-Radical Cofactor of Escherichia coli Ribonucleotide Reductase†

Lana Saleh; Carsten Krebs; Brenda A. Ley; Sunail Naik; Boi Hanh Huynh; J. Martin Bollinger

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J. Martin Bollinger

Pennsylvania State University

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Jeffrey W. Baldwin

Pennsylvania State University

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Carsten Krebs

Pennsylvania State University

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Dale E. Edmondson

Emory University

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Boi Hanh Huynh

Emory University

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Lana Saleh

New England Biolabs

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Nelly Khidekel

California Institute of Technology

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Pierre Moënne-Loccoz

Oregon Health

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Shuxian Chen

Emory University

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Thomas M. Loehr

Oregon Health

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