Masahiko Yoneta

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Bioorganic & Medicinal Chemistry Letters | 1995

Tetsuro Fujita; Masahiko Yoneta; Ryoji Hirose; Shigeo Sasaki; Kenichiro Inoue; Masatoshi Kiuchi; Susumu Hirase; Kunitomo Adachi; Masafumi Arita; Kenji Chiba

Abstract ISP-I (myriocin, thermozymocidin) was structurally simplified to give 2-amino-2-alkyl-1,3-propanediols that were also potent immunosuppressants. Among the series, 2-amino-2-pentadecyl-1,3-propanediol most actively prolonged rat skin allograft survival and was more effective than ciclosporin.

Bioorganic & Medicinal Chemistry Letters | 1995

Tetsuro Fujita; Ryoji Hirose; Norimitsu Hamamichi; Yuuki Kitao; Shigeo Sasaki; Masahiko Yoneta; Kenji Chiba

Abstract 2-Substituted 2-aminoethanol was shown to be the minimum essential structure for the immunosuppressive activity of ISP-i (myriocin, thermozymocidin) by simplification of 2-substituted 2-amino-1,3-propanediol, which was generated by modification of ISP-I. Among the series, 2-amino-4-(4-octylphenyl)butanol hydrochloride displayed comparably potent activity to 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride, FTY720.

Archive | 1993

Tetsuro Fujita; Shigeo Kobe-shi Sasaki; Masahiko Yoneta; Tadashi Mishina; Kunitomo Adachi; Kenji Yoshitomi Pharmac. Ind. Ltd Chiba

Journal of Medicinal Chemistry | 1996

Tetsuro Fujita; Ryoji Hirose; Masahiko Yoneta; Shigeo Sasaki; Kenichiro Inoue; Masatoshi Kiuchi; Susumu Hirase; Kenji Chiba; Hiroshi Sakamoto; Masafumi Arita

The Journal of Antibiotics | 1996

Tetsuro Fujita; Norimitsu Hamamichi; Masatoshi Kiuchi; Tohru Matsuzaki; Yuki Kitao; Kenichiro Inoue; Ryoji Hirose; Masahiko Yoneta; Shigeo Sasaki; Kenji Chba

Archive | 1999