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Susumu Hirase

Mitsubishi

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Publication

Featured researches published by Susumu Hirase.

Bioorganic & Medicinal Chemistry Letters | 1995

Simple compounds, 2-alkyl-2-amino-1,3-propanediols have potent immunosuppressive activity

Tetsuro Fujita; Masahiko Yoneta; Ryoji Hirose; Shigeo Sasaki; Kenichiro Inoue; Masatoshi Kiuchi; Susumu Hirase; Kunitomo Adachi; Masafumi Arita; Kenji Chiba

Abstract ISP-I (myriocin, thermozymocidin) was structurally simplified to give 2-amino-2-alkyl-1,3-propanediols that were also potent immunosuppressants. Among the series, 2-amino-2-pentadecyl-1,3-propanediol most actively prolonged rat skin allograft survival and was more effective than ciclosporin.

Journal of Medicinal Chemistry | 1996

Potent immunosuppressants, 2-alkyl-2-aminopropane-1,3-diols

Tetsuro Fujita; Ryoji Hirose; Masahiko Yoneta; Shigeo Sasaki; Kenichiro Inoue; Masatoshi Kiuchi; Susumu Hirase; Kenji Chiba; Hiroshi Sakamoto; Masafumi Arita

Archive | 1999

Process for preparing 2-amino malonic acid derivatives and 2-amino-1,3-propanediol derivatives, and intermediates for preparing the same

Susumu Hirase; Shigeo Sasaki; Masahiko Yoneta; Ryoji Hirose; Tetsuro Fujita

Archive | 1998

Processes for producing 2-aminomalonic acid derivatives and 2-amino-1,3-propanediol derivatives, and intermediates for producing the derivatives

Susumu Hirase; Shigeo Sasaki; Masahiko Yoneta; Ryoji Hirose; Tetsuro Fujita

Archive | 1998

A process for preparing 2-aminomalonic acid derivatives

Tetsuro Fujita; Susumu Hirase; Ryoji Hirose; Shigeo Sasaki; Masahiko Yoneta

Archive | 1997

Process for the preparation of 2-aminomalonic acid derivatives and intermediates used in the process

Susumu Hirase; Shigeo Sasaki; Masahiko Yoneta; Ryoji Hirose; Tetsuro Fujita

Archive | 2004

PROCESSO PARA A PREPARACAO DE DERIVADOS DE ACIDO 2-AMINOMALONICO

Fujita Tetsuro; Susumu Hirase; Shigeo Sasaki; Masahiko Yoneta; Ryoji Hirose

Archive | 1998

Verfahren zur herstellung von 2-aminomalonsäure-derivaten A process for producing 2-aminomalonic acid derivatives

Susumu Hirase; Shigeo Sasaki; Masahiko Yoneta; Ryoji Hirose; Tetsuro Fujita

Archive | 1998

Procedes de production de derives d'acide 2-aminomalonique et de derives de 2-amino-1,3-propanediol, et des intermediaires permettant la production de ces derives

Susumu Hirase; Shigeo Sasaki; Masahiko Yoneta; Ryoji Hirose; Tetsuro Fujita

Archive | 1998

A process for preparing derivatives of 2-aminomalonic.

Tetsuro Fujita; Susumu Hirase; Ryoji Hirose; Shigeo Sasaki; Masahiko Yoneta

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Masahiko Yoneta

Mitsubishi

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Ryoji Hirose

Mitsubishi

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Shigeo Sasaki

Mitsubishi

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Tetsuro Fujita

Mitsubishi

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Kenichiro Inoue

Kyoto University

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Kenji Chiba

Mitsubishi Tanabe Pharma

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Masafumi Arita

University of Tokyo

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Masatoshi Kiuchi

Kyoto University

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Kunitomo Adachi

University of Tokyo

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