Mauricio Ferreira da Rosa

Synthesis and Evaluation of New β-Carboline-3-(4-benzylidene)- 4H-oxazol-5-one Derivatives as Antitumor Agents

In the present work, we report the synthesis and in vitro anticancer and antimicrobial activity evaluation of a new series of 1-substituted-β-carboline derivatives bearing a 4-benzylidene-4H-oxazol-5-one unity at C-3. The compound 2-[1-(4-methoxyphenyl)-9H-β-carbolin-3-yl]-4-(benzylidene)-4H-oxazol-5-one (11) was the most active derivative, exhibiting a potent cytotoxic activity against glioma (U251), prostate (PC-3) and ovarian (OVCAR-03) cancer cell lines with IC50 values of 0.48, 1.50 and 1.07 µM, respectively. An in silico study of the ADME properties of the novel synthesized β-carboline derivatives was also performed.

Degradação fotocalítica de bentazona com TiO2

This study evaluated the oxidative degradation of the post-emerging herbicide Basagran(r) 600 by photolysis and photocatalysis using TiO2 as catalyst, and both processes were compared in their efficiency. The experiments were done irradiating aqueous solutions of the herbicide in a slurry type reactor. The treatments were accompanied by spectrophotometry in the UV-visible range observing the band centered in 335 nm. The first process showed rather ineffective, being observed minimal reduction of the absorbance values. On the other hand, the second process was much more efficient, being observed, after 270 min of irradiation, 100% absorbance reduction of the band in the choose wavelength. This process followed pseudo-first-order kinetic and the estimated rate constant (k) was 0.0116 min-1.

Chemical Composition of the Essential Oil Obtained from Ocimum basilicum (Basil) Cultivated in Two Regions from South Brazil

Abstract A comparative study of the chemical composition of essential oils of basil (Ocimum basilicum L.) grown in different localities in southern Brazil was conducted. This plant is seen as a promising source of linalool, a substance widely used in cosmetics and fragrances. The main objective of this study was to determine whether the procedures of drying plant and geographic origin of material plant (municipalities of Toledo (PR) and Jardinópolis (SC), south Brazil) provide significant changes in the chemical composition of essential oil. As a result, there were no significant differences in chemical composition of the oil from different regions, while the drying procedure has profoundly altered the chemical profile of the oil. Plant drying under sun reduced the concentration of linalool in the essential oil. These results can support future projects of essential oil production in these regions, characterized by the presence of small farms with a high incidence of family labor, which may represent a new source of income with a product with high added value.

Estudo de estabilidade do fosfato dissódico de prednisolona em condições de estresse oxidativo e térmico, em formulação oral

This work was to investigate the process of degradation of the drug Prednisolone Sodium Phosphate (FSP) in oral solution dosage form through the degradation experiments, evaluating the parameters in accordance with Resolution 899/2003 ANVISA and the degradation process of the drug. The method by high performance liquid chromatography (HPLC) developed for the determination of the drug was validated to demonstrate its applicability as an indicator of stability, ensuring reliability. After the method be validated to study the degradation of the drug, it was shown that drastic conditions of oxidative stress (H2O2 30%) and temperature 60 ° C, the degradation of the drug is dependent on its concentration (first order kinetics). The results were satisfactory, showing that this method is suitable to investigate the formation of degradation products in oral dosage form solution.

Degradação hidrolítica e fotoquímica da amoxicilina na presença de β-ciclodextrina

This work has like purpose monitors the degradation of the drug amoxicillin in the presence and absence of β-cyclodextrin, through techniques spectroscopy. For this, there was accompanied the hydrolysis of the drug protected of the light for around 400 hours. The results indicate that, initially, the cyclodextrin does not alter the hydrolysis of the amoxicillin, however, after 250 hours there is an increase of the hydrolysis of the amoxicillin when present at cyclodextrin. Another variable was the irradiation of the sample with radiation in the region of the UV, we see that the solutions containing β-cyclodextrin suffer a slower phototransformation (26,8%) than the solutions without β-cyclodextrin, when irradiated by UV radiation.

Synthesis and Application of Acetil-β-cyclodexitrin on Essential Oil

Abstract This work presents the structural modification of the β-cyclodextrin through acetylation reaction, the spectroscopic characterization of the product (acetyl-β-cyclodextrin) in the mid infrared region, NMR of 1H, 13C and DEPT135, and the use of these compounds on essential oil of clove as photoprotectors and reducers of evaporation loss. The photodegradation experiments were done in alcoholic solutions and both compounds showed good photoprotective properties, although β-cyclodextrin has presented a better performance. In the presence of 5x10-4mol L-1 of β-cyclodextrin was observed a reduction of 72 % in the degradation rate while for the acetyl derivative, in the same concentration, this rate was lowered in 38 %. On the other hand, acetyl-β-cyclodextrin showed very good results in the evaporation assays, lowering the mass loss in 52 % when compared with the oil without this derivative in the same experimental conditions. So, the results presented here point out acetyl-β-cyclodextrin applicability for the complexation of essential oil of clove, reducing its volatility and increasing its photochemical stability.