Cleber Antonio Lindino

Estudo de estabilidade do fosfato dissódico de prednisolona em condições de estresse oxidativo e térmico, em formulação oral

This work was to investigate the process of degradation of the drug Prednisolone Sodium Phosphate (FSP) in oral solution dosage form through the degradation experiments, evaluating the parameters in accordance with Resolution 899/2003 ANVISA and the degradation process of the drug. The method by high performance liquid chromatography (HPLC) developed for the determination of the drug was validated to demonstrate its applicability as an indicator of stability, ensuring reliability. After the method be validated to study the degradation of the drug, it was shown that drastic conditions of oxidative stress (H2O2 30%) and temperature 60 ° C, the degradation of the drug is dependent on its concentration (first order kinetics). The results were satisfactory, showing that this method is suitable to investigate the formation of degradation products in oral dosage form solution.

Degradação hidrolítica e fotoquímica da amoxicilina na presença de β-ciclodextrina

This work has like purpose monitors the degradation of the drug amoxicillin in the presence and absence of β-cyclodextrin, through techniques spectroscopy. For this, there was accompanied the hydrolysis of the drug protected of the light for around 400 hours. The results indicate that, initially, the cyclodextrin does not alter the hydrolysis of the amoxicillin, however, after 250 hours there is an increase of the hydrolysis of the amoxicillin when present at cyclodextrin. Another variable was the irradiation of the sample with radiation in the region of the UV, we see that the solutions containing β-cyclodextrin suffer a slower phototransformation (26,8%) than the solutions without β-cyclodextrin, when irradiated by UV radiation.

Lead adsorption and subsequent gasification with Pinus elliottii waste

Purpose The purpose of this paper is to investigate the use of Pinus wood waste in lead adsorption as a remediation technique in aqueous medium and its subsequent use in obtaining synthesis gas. Design/methodology/approach The capacity of the timber in the lead adsorption was studied in aqueous medium at various pH, determining the amount adsorbed in equilibrium. Then, the same timber was added in a fixed bed, co-current flow of two stage gasifier type, working temperature of 900°C, for obtaining synthesis gas. The synthesis gas composition was evaluated by the spectrophotometry in the infrared region and the gas chromatography and lead content in the ash and gas was determined by the atomic absorption spectrophotometry. Findings In laboratory tests carried out, the optimal pH for lead removal was pH 4 with 96.15 percent removal rate, reaching equilibrium after 180 min. In pilot scale the lead removal after 72 hours was 96 percent. The average production of syngas was 11.09 m³h−1. For tests with the motor-generator, the best condition occurred with charge of 2.0 kW, wherein gas consumption per kW produced reached 4.86 m³ kW−1, resulting in a 14.81 percent efficiency rate. The gas analysis showed an average concentration of 14.85 percent H2, 30.1 percent CO2, and 50.49 percent of atmospheric air. The concentration of lead in the gas was below the limit established by law. Pinus elliottii waste proved to be an excellent adsorbent, with removing more than 96 percent of the Pb ion present in aqueous solution and a starting material in the gasifier to generate synthesis gas. Research limitations/implications This paper describes the waste wood application in the treatment of contaminated environments and for obtaining syngas providing a sustainable process. Originality/value This paper shows a process that combines the remediation of contaminated environmental with power generation systems, allowing efficient management of contaminated environments.

Biogas production with co-digestion of sugarcane straw

Purpose The purpose of this paper is to investigate straw modification by chemical degradation generated by two forms of pretreatment, using citric acid in an autoclave and urea solution with sodium hydroxide at low temperature. Design/methodology/approach The material was digested and compared in biodigester reactors lined with natural straw, straw pretreated with citric acid, straw pretreated with urea and NaOH, and straw subjected to both the pretreatments. The amount of straw has been delimited to 0, 2.5, 5, 7.5 and 10 percent v/v, and used 20 percent v/v inoculum in all reactors, consisting of 30 percent v/v poultry litter and 70 percent swine wastewater (SW). The experiment was conducted in an incubator kept in mesophilic conditions (35°C). Findings The results indicate significant change in the studied material, with degradation of lignin as well as hemicellulose and cellulose exposed to further hydrolysis. Spectrophotometric methods were used for monitoring degradation. These methods were efficient in monitoring changes caused by the treatments. When the proposed pretreatments are applied to sugarcane straw, there is a significant gain in biogas production (L g VSR−1). The most appropriate rates for higher methane production in the pretreatments are 2.5 and 5 percent straw-SW. The best results for the anaerobic digestion of sugarcane straw were obtained by pretreating it with citric acid. Originality/value This paper shows a new use for the sugarcane straw waste after being pretreated with acid or base for the coproduction of biogas.

DEGRADAÇÃO DO AGROTÓXICO CONNECT® COM FOTOCATALISADOR HIDROXIAPATITA

A utilizacao da hidroxiapatita como fotocatalisador e uma tecnologia promissora, pois e um material nao toxico e de facil obtencao e suas caracteristicas estruturais e fisico-quimicas podem ser alteradas dependendo da metodologia de sintese e dos dopantes incorporados em sua estrutura. Este trabalho estudou a eficiencia da hidroxiapatita como catalisador heterogeneo na degradacao do agrotoxico Connect ® , utilizando-se radiacao UV e radiacao solar. A hidroxiapatita foi sintetizada por precipitacao homogenea e dopada com metais de transicao. A eficiencia fotocatalitica foi dependente da hidroxiapatita utilizada, devido as alteracoes em sua cristalinidade, na area superficial, no tamanho dos poros, na capacidade de adsorcao e na estabilidade. A hidroxiapatita apresentou eficiencia de 100 % na fotodegradacao do agrotoxico Connect ® , (dopantes W e V), com radiacao UV, em uma hora de irradiacao. Utilizando-se radiacao solar, foram necessarias 20 h de exposicao (dopantes Zn ou Cr) para total degradacao do agrotoxico, indicando a influencia do metodo de preparacao. A degradacao total do agrotoxico com radiacao UV e com radiacao solar ocorreu em diferentes tempos de exposicao permitindo a diminuicao de seus efeitos poluidores no ambiente.

PRÉ-TRATAMENTOS NA PRODUÇÃO DE ETANOL DE SEGUNDA GERAÇÃO

The increasing in ethanol production without expansion of plantation areas has been studied in Brazil, more intensively since the Proalcool initiative. The cellulosic biofuel is considered an alternative to expand this production in large scale for it does not only allow the use of sugar cane bagasse, as well as any lignocellulosic material, and uneatable plant parts, besides, the environmental appeal enables the short term production. One of the challenges is to improve the process of hydrolysis of cellulose and hemicellulose, once that he first presents an almost crystalline structure and the second has a less regular structure. This paper aims to report the main used pre-treatments aiming to expose the cellulose and hemicellulose for hydrolysis (saccharification). The greatest challenge is due to the metabolization of the polysaccharide that is gradually impaired as the complexity of its chain increases. The degradation of cellulose weaves a network of several possibilities including even the fuel production for jet aircraft. Even with the fact that this area of research is recent, there is already such a pilot plant for production and the first refineries installed went into operation in 2011, however, in order to spread and gain markets it will have compete with the powerful oil market.

INFLUÊNCIA DA DENSIDADE DE PLANTIO NO CRESCIMENTO DA LINHAÇA MARROM

Flaxseed can be consumed as food or feed, besides being used for various other purposes, has a percentage of protein in equal proportion of fibers and mostly oil, usually the product of interest in culture can be grown brown and golden flaxseed. The objective of this study was to analyze the influence of population densities in the culture of brown flaxseed (Linum usitatissimum L.) using the online system of planting, being spaced at 0.45 m. The experiment was conducted at the State University of West Parana, year 2013 campus, using a completely randomized design with eight systems of planting density: 67, 84, 99, 117, 137, 154, 172 and 190 plants/m2 with six replicates, we performed 130 days after harvesting crops. The vegetative behavior was assessed following the variables fenometric plant height, stem diameter, number of branches of the stem, fresh and dry mass of the aerial part of the plant, number of capsules, fresh and dry seeds. Evaluating the data plotted in generated by applying the Tukey test, the table can not infer the best for high density planting of brown flaxseed aiming to yield grain, only it was noted that high density below 99 plants/m 2 reduce productivity in grain brown.

Preparação de eletrodos de hidroxiapatita por diferentes metodologias de síntese e sua aplicação na determinação de fosfito em fertilizantes líquidos

A determinacao de fosfito em fertilizantes liquidos e muito importante para o controle de qualidade destes produtos. Metodos classicos de analise incluem principalmente metodologias gravimetricas ou espectrofotometricas que geram residuos quimicos toxicos. Este trabalho descreve a construcao de um eletrodo potenciometrico alternativo baseado em hidroxiapatita na determinacao do fosfito. Uma resposta eletroquimica linear foi obtida para a concentracao de fosfito entre os valores de 1 x 10 -5 a 1 x 10 -1 mol L -1 . Os resultados obtidos pelo metodo proposto estao de acordo com aqueles obtidos pelo metodo gravimetrico ao nivel de confianca de 95% para a determinacao direta em fertilizantes liquidos.