John E. Thornton | Researchain

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Featured researches published by John E. Thornton.

Tetrahedron Letters | 2002

Synthesis of substituted 2,3-dihydrobenzofuran in a process involving a facile acyl migration

Wen-Sen Li; Zhenrong Guo; John E. Thornton; Kishta Katipally; Richard Polniaszek; John K. Thottathil; Truc Chi Vu; Michael Wong

Abstract Reduction of 2,6-diacetoxy-2′-bromoacetophenone ( 10 ) with NaBH 4 led to 3,4-diacetoxydihydrobenzofuran ( 12 ) in a process involving acyl migration followed by cyclization. Subsequent hydrogenolysis gave 4-acetoxydihydrobenzofuran which, upon saponification, afforded 4-hydroxydihydrobenzofuran ( 8 ) in good yield. This approach is shown to be a general method for preparation of substituted dihydrobenzofurans.

Archive | 2001

Process for the preparation of epothilone analogs

Wen Sen Li; John E. Thornton; Zhenrong Guo; Shankar Swaminathan

Organic Process Research & Development | 2003

Development of Jacobsen Asymmetric Epoxidation and Sharpless Asymmetric Dihydroxylation Methods for the Large-Scale Preparation of a Chiral Dihydrobenzofuran Epoxide

J. Siva Prasad; Truc Chi Vu; Michael J. Totleben; Gerard Crispino; David Kacsur; Shankar Swaminathan; John E. Thornton; and Alan Fritz; Ambarish K. Singh

Archive | 2001

A process for the preparation of epothilone analogs and intermediates

Wen Sen Li; John E. Thornton; Zhenrong Guo; Shankar Swaminathan

Organic Process Research & Development | 2014

Commercial Synthesis of a Pyrrolotriazine–Fluoroindole Intermediate to Brivanib Alaninate: Process Development Directed toward Impurity Control

Jaan A. Pesti; Thomas L. LaPorte; John E. Thornton; Lori Spangler; Frederic G. Buono; Gerard Crispino; Frank Gibson; Paul C. Lobben; Christos G. Papaioannou

Archive | 2009

Crystalline forms of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester

John E. Thornton

Archive | 2007

Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2, 1-F][1,2,4]triazin-6-yloxy]-1-methylethyl ester

Gerard Crispino; Mourad Hamedi; Thomas L. LaPorte; John E. Thornton; Jaan A. Pesti; Zhongmin Xu; Paul C. Lobben; David K. Leahy; Jale Muslehiddinoglu; Chiajen Lai; Lori Spangler; Robert P. Discordia

Archive | 2007

Process for preparation of ester of 2- [4- (4-fluoro-2-methyl-1H-indol-5-yloxy) -5-methylpyrrolo] 2,1-f- [1,2,4 triazin-6- yloxy] -1-methyl acid [(1R), 2S] -2-aminopropionic

Gerard Crispino; Mourad Hamedi; Thomas L. LaPorte; John E. Thornton; Jaan A. Pesti; Zhongmin Xu; Paul C. Lobben; David K. Leahy; Jale Muslehiddinoglu; Chiajen Lai; Lori Spangler; Robert P. Discordia

Archive | 2007

Procede de synthese du [(1r),2s]-2-aminopropionate de 2-[4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyle

Gerard Crispino; Mourad Hamedi; Thomas L. LaPorte; John E. Thornton; Jaan A. Pesti; Zhongmin Xu; Paul C. Lobben; David K. Leahy; Jale Muslehiddinoglu; Chiajen Lai; Lori Spangler; Robert P. Discordia

Archive | 2007

Fremgangsmåde til fremstilling af [(1R), 2S]-2-aminopropionsyre 2-[4-(4-fluor-2-methyl-1H-indol-5-yloxy)-5-methylpyrrol]2,1-f-[1,2,4-triazin-6-yloxy]-1-methylethylester

Gerard Crispino; Mourad Hamedi; Thomas L. LaPorte; John E. Thornton; Jaan A. Pesti; Zhongmin Xu; Paul C. Lobben; David K. Leahy; Jale Muslehiddinoglu; Chiajen Lai; Robert P. Discordia; Lori Spangler

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