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Gerard Crispino

Bristol-Myers Squibb

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Publication

Featured researches published by Gerard Crispino.

Tetrahedron Letters | 2003

A mild and efficient synthesis of 4-aryl-quinolin-2(1H)-ones via a tandem amidation/Knoevenagel condensation of 2-amino-benzophenones with esters or lactones

Jianji Wang; Robert P. Discordia; Gerard Crispino; Jun Li; John Anthony Grosso; Richard Polniaszek; Vu Truc

Abstract Using LiHMDS as the base, a tandem amidation/Knoevenagel condensation of 2-aminobenzophenones with α-methylene esters or lactones gives 4-aryl-quinolin-2(1H)-ones in 65–96% yield. This method is mild, highly efficient, and amenable to scaleup.

Tetrahedron Letters | 2003

Selective removal of a benzyl protecting group in the presence of an aryl chloride under gaseous and transfer hydrogenolysis conditions

Jun Li; Steve Wang; Gerard Crispino; Karen Tenhuisen; Ambarish K. Singh; John Anthony Grosso

Abstract Selective removal of a benzyl protecting group in the presence of an aryl chloride using Pd/C under gaseous and transfer hydrogenolysis conditions is described. The addition of chloride salts to the debenzylation reaction provides excellent selectivity.

Archive | 2003

Methods of producing c-aryl glucoside sglt2 inhibitors

Prashant P. Deshpande; Bruce A. Ellsworth; Janak Singh; Theodor Denzel; Chiajen Lai; Gerard Crispino; Michael E. Randazzo; Jack Z. Gougoutas

Organic Process Research & Development | 2012

A Practical Stereoselective Synthesis and Novel Cocrystallizations of an Amphiphatic SGLT-2 Inhibitor

Prashant P. Deshpande; Janak Singh; Annie Pullockaran; Thomas P. Kissick; Bruce A. Ellsworth; Jack Z. Gougoutas; John D. Dimarco; Michael Fakes; Mayra Reyes; Chiajen Lai; Hidegard Lobinger; Theo Denzel; Peter H. Ermann; Gerard Crispino; Michael E. Randazzo; Zenrong Gao; Renee Randazzo; Mark D. Lindrud; Victor W. Rosso; Frederic G. Buono; Wendel W. Doubleday; Simon Leung; Pricilla Richberg; David L. Hughes; William N. Washburn; Wei Meng; Kevin J. Volk; Richard H. Mueller

Archive | 2005

Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors

Gerard Crispino; Stephanie Barbosa; Junying Fan; Zhen-Wei Cai

Organic Process Research & Development | 2003

Development of Jacobsen Asymmetric Epoxidation and Sharpless Asymmetric Dihydroxylation Methods for the Large-Scale Preparation of a Chiral Dihydrobenzofuran Epoxide

J. Siva Prasad; Truc Chi Vu; Michael J. Totleben; Gerard Crispino; David Kacsur; Shankar Swaminathan; John E. Thornton; and Alan Fritz; Ambarish K. Singh

Organic Process Research & Development | 2014

Commercial Synthesis of a Pyrrolotriazine–Fluoroindole Intermediate to Brivanib Alaninate: Process Development Directed toward Impurity Control

Jaan A. Pesti; Thomas L. LaPorte; John E. Thornton; Lori Spangler; Frederic G. Buono; Gerard Crispino; Frank Gibson; Paul C. Lobben; Christos G. Papaioannou

Organic Process Research & Development | 2000

A Practical Synthesis of an Anti-Methicillin Resistant Staphylococcus aureus Cephalosporin BMS-247243

Janak Singh; Oak K. Kim; Thomas P. Kissick; Kenneth J. Natalie; Bo Zhang; Gerard Crispino; Dane M. Springer; John A. Wichtowski; Yunhui Zhang; Jason Goodrich; Yasutsugu Ueda; Bing Y. Luh; Brian D. Burke; Matthew Brown; Anthony P. Dutka; Bin Zheng; ‡ Dau-Ming Hsieh; Michael Humora; Jeffrey T. North; Anne J. Pullockaran; Juliya Livshits; Shankar Swaminathan; Zhinong Gao; Peter Schierling; Peter H. Ermann; Robert Kevin Perrone; Mei C. Lai; Jack Z. Gougoutas; John D. Dimarco; Joanne J. Bronson

Archive | 2000

PREPARATION OF 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES

Gerard Crispino; Shaopeng Wang; Jun Li

Archive | 2007

Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2, 1-F][1,2,4]triazin-6-yloxy]-1-methylethyl ester

Gerard Crispino; Mourad Hamedi; Thomas L. LaPorte; John E. Thornton; Jaan A. Pesti; Zhongmin Xu; Paul C. Lobben; David K. Leahy; Jale Muslehiddinoglu; Chiajen Lai; Lori Spangler; Robert P. Discordia

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Collaboration

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Chiajen Lai

Bristol-Myers Squibb

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John E. Thornton

Bristol-Myers Squibb

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Jaan A. Pesti

Bristol-Myers Squibb

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Jack Z. Gougoutas

Bristol-Myers Squibb

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Janak Singh

Loyola University New Orleans

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Jun Li

Bristol-Myers Squibb

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Lori Spangler

Bristol-Myers Squibb

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Paul C. Lobben

Bristol-Myers Squibb

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Robert P. Discordia

Bristol-Myers Squibb

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Thomas L. LaPorte

Bristol-Myers Squibb

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