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Zhi-Fu Tao

Tokyo Medical and Dental University

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Publication

Featured researches published by Zhi-Fu Tao.

Nucleosides, Nucleotides & Nucleic Acids | 1999

SEQUENCE-SPECIFIC ALKYLATION OF DNA BY DUOCARMYCIN A AND ITS NOVEL DERIVATIVES BEARING PY/IM POLYAMIDES

Zhi-Fu Tao; Tsuyoshi Fujiwara; Isao Saito; Hiroshi Sugiyama

A new class of sequence-specific DNA alkylating agents were developed based on the reactivity of duocarmycin A and the DNA-reading ability of pyrrole-imidazole polyamide. The DNA alkylation sequence specificity by duocarmycin A can be modulated by a variety of pyrrole-imidazole triamides in a predictable manner. Novel hybrids of the segment A of duocarmycin A and pyrrole-imidazole polyamides efficiently and highly selectively alkylated the target base possessing match sequences of Dervans binding code.

Journal of the American Chemical Society | 1999

Rational Design of Sequence-Specific DNA Alkylating Agents Based on Duocarmycin A and Pyrrole−Imidazole Hairpin Polyamides

Zhi-Fu Tao; Tsuyoshi Fujiwara; Isao Saito; Hiroshi Sugiyama

Nucleic Acids Research | 1999

Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatched base pairs

Xiang-Lei Yang; Richard B. Hubbard; Moses Lee; Zhi-Fu Tao; Hiroshi Sugiyama; Andrew H.-J. Wang

Chemistry & Biology | 2003

Sequence specificity, reactivity, and antitumor activity of DNA-alkylating pyrrole-imidazole diamides.

Toshikazu Bando; Hirokazu Iida; Zhi-Fu Tao; Akihiko Narita; Noboru Fukuda; Takao Yamori; Hiroshi Sugiyama

Journal of the American Chemical Society | 2000

Highly Cooperative DNA Dialkylation by the Homodimer of Imidazole−Pyrrole Diamide−CPI Conjugate with Vinyl Linker

Zhi-Fu Tao; Isao Saito; Hiroshi Sugiyama

Angewandte Chemie | 1999

Sequence-Specific DNA Alkylation by Hybrid Molecules between Segment A of Duocarmycin A and Pyrrole/Imidazole Diamide

Zhi-Fu Tao; Tsuyoshi Fujiwara; Isao Saito; Hiroshi Sugiyama

Journal of the American Chemical Society | 1999

Modulation of Sequence Specificity of Duocarmycin-Dependent DNA Alkylation by Pyrrole-Imidazole Triamides

Tsuyoshi Fujiwara; Zhi-Fu Tao; Yohei Ozeki; Isao Saito; Hailan Wang; Moses Lee; Hiroshi Sugiyama

Nucleic Acids Research | 2002

Sequence‐specific protection of plasmid DNA from restriction endonuclease hydrolysis by pyrrole–imidazole–cyclopropapyrroloindole conjugates

Kazuhisa Fujimoto; Hirokazu Iida; Masako Kawakami; Toshikazu Bando; Zhi-Fu Tao; Hiroshi Sugiyama

Archive | 2000

Compounds capable of cleaving double-stranded dna and method of utilization of the same

Hiroshi Sugiyama; Zhi-Fu Tao; Isao Saito

Nucleic Acids Symposium Series | 1999

Synthesis of pyrrole-imidazole-duocarmycin polyamide and its sequence selective DNA alkylation

Tsuyoshi Fujiwara; Zhi-Fu Tao; Isao Saito; Hiroshi Sugiyama

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Collaboration

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Hiroshi Sugiyama

Kyoto University

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Isao Saito

Kyoto University

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Tsuyoshi Fujiwara

Kyoto University

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Hirokazu Iida

Tokyo Medical and Dental University

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Toshikazu Bando

Tokyo Medical and Dental University

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Moses Lee

Furman University

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Akihiko Narita

Tokyo Medical and Dental University

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Hailan Wang

Nagoya University

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Kazuhisa Fujimoto

Tokyo Medical and Dental University

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Masako Kawakami

Tokyo Medical and Dental University

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