Noriyuki Kawahata
ARIAD Pharmaceuticals, Inc.
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Noriyuki Kawahata.
Bioorganic & Medicinal Chemistry Letters | 2003
Chi B. Vu; George P. Luke; Noriyuki Kawahata; William C. Shakespeare; Yihan Wang; Raji Sundaramoorthi; Chester A. Metcalf; Terence P. Keenan; Selvi Pradeepan; Evelyn G. Corpuz; Taylor Merry; Regine S. Bohacek; David C. Dalgarno; Surinder S. Narula; Marie Rose van Schravendijk; Mary K. Ram; Susan Adams; Shuenn Liou; Jeffrey Keats; Shelia M. Violette; Wei Guan; Manfred Weigele; Tomi K. Sawyer
The design of bone-targeted pyrido[2,3-d]pyrimidin-7-ones as Src tyrosine kinase inhibitors is described. Leveraging SAR from known compounds and using structure-based methods, we were able to rapidly incorporate bone binding components, which maintained, and even increased potency against the target enzyme. Compound 4 displayed a high affinity for hydroxyapatite, a major constituent of bone, and demonstrated antiresoprtive activity in our cell-based assay.
Mini-reviews in Medicinal Chemistry | 2002
Tomi K. Sawyer; Regine Bohacek; David C. Dalgarno; Charles J. Eyermann; Noriyuki Kawahata; Chester A. Metcalf; William C. Shakespeare; Raji Sundaramoorthi; Yihan Wang; Michael G. Yang
Archive | 2009
Huw M. Nash; Rosanna Kapeller-Libermann; Tomi K. Sawyer; Noriyuki Kawahata; Vincent Guerlavais; Matthew Iadanza
Archive | 2009
Huw M. Nash; David Allen Annis; Rosana Kapeller-Libermann; Tomi K. Sawyer; Noriyuki Kawahata; Jiawen Han
Archive | 2009
Huw M. Nash; David Allen Annis; Rosana Kapeller-Libermann; Tomi K. Sawyer; Noriyuki Kawahata
Biopolymers | 2003
Raji Sundaramoorthi; Noriyuki Kawahata; Michael G. Yang; William C. Shakespeare; Chester A. Metcalf; Yihan Wang; Taylor Merry; Charles J. Eyermann; Regine S. Bohacek; Surinder S. Narula; David C. Dalgarno; Tomi K. Sawyer
Bioorganic & Medicinal Chemistry Letters | 2001
Noriyuki Kawahata; Michael G. Yang; George P. Luke; William C. Shakespeare; Raji Sundaramoorthi; Yihan Wang; Daniel Johnson; Taylor Merry; Shelia M. Violette; Wei Guan; Catherine Bartlett; Jeremy Smith; Marcos Hatada; Xiaode Lu; David C. Dalgarno; Charles J. Eyermann; Regine S. Bohacek; Tomi K. Sawyer
Archive | 2009
Huw M. Nash; Matthew Iadanza; Christopher Leitheiser; Noriyuki Kawahata
Archive | 1998
Manfred Weigele; Regine S. Bohacek; Virginia A. Jacobsen; Karina Macek; Michael G. Yang; Noriyuki Kawahata; Rajeswari Sundaramoorthi; Yihan Wang; Craig Takeuchi; George P. Luke; Chester A. Metcalf; William C. Shakespeare; Tomi K. Sawyer
Archive | 2014
Vincent Guerlavais; Noriyuki Kawahata; Huw M. Nash; Carl Elkin; Eric Feyfant
